On the Hyperbilirubinemic and Hypersideremic Action of Nicotinic Acid on Normal Subjects and on Patients with some Hematological Disorders

Gydell, Karl

doi:10.1111/j.0954-6820.1958.tb01749.x

Cited by 11 publications

(3 citation statements)

References 12 publications

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“…Nor can the second study, in which an increased haemolysis was induced by giving nicotinic acid be considered a quantitative study. However, it is justified to assume from previous studies (Gydell 1958) that the release of iron is increased for at least one hour in normal subjects. No attempts were made to quantitate the degree of the increased haemolysis in our four subjects.…”

Section: Discussionmentioning

confidence: 99%

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The Effect of Desferrioxamine on Iron Metabolism in Man. II

Hallberg

Hedenberg

1965

Scandinavian Journal of Haematology

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The influence of an increased haemolysis on the urinary iron excretion after the administration of desferrioxamine (DF) was studied in a series of experiments. An increased haemolysis was induced by transfusing stored red cells, by injecting nicotinic acid or by infusing antibody‐coated red cells. The results indicate that under normal conditions, the urinary iron excreted with DF does not originate from destroyed red cells. Iron absorbed from the intestines is no probable source of the iron excreted in the urine with DF, as judged from a study in which the iron excretion was compared during periods with iron‐rich and iron‐free diets. The results of our present and previous studies indicate that stored iron is the probable main source of the iron excreted with DF in the urine.

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Section: Discussionmentioning

confidence: 99%

“…An increased extravascular destruction of red cells can be induced by injecting nicotinic acid intravenously (for a review see Gydell 1958). Gydell found that increased concentrations of bilirubin, plasma iron, and carbon monoxide were obtained after giving i.e.…”

Section: Znjection Of Nicotinic Acidmentioning

confidence: 99%

The Effect of Desferrioxamine on Iron Metabolism in Man. II

Hallberg

Hedenberg

1965

Scandinavian Journal of Haematology

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“…The absolute amount of heme turned over in the NA test has not been known for certain. From calculations based on changes in serum bilirubin and serum iron and a simultaneous determination of plasma volume, Gydell (5) calculated the amount of extra H b broken down t o 0.5 g, corresponding to a twofold increase in normal H b turnover for two hours.…”

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confidence: 99%

Nicotinic Acid and the Endogenous Production of Carbon Monoxide

Lundh

Cavallin‐Ståhl

Mercke

1975

Journal of Internal Medicine

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The endogenous production of carbon monoxide (V̇CO) has been followed with the aid of a rebreathing system for 3 hours in four healthy volunteers after i.v. injection of 50 mg nicotinic acid (NA). After an initial slight decrease for 15–30 min in the CO hemoglobin per cent saturation (COHb), a rapid increase was registered for 120 min, whereafter the V̇CO returned to the normal, preinjection level. The amount of “extra” CO produced varied between 4.1 and 2.2 ml, corresponding to 2.9 and 1.6 g Hb or 182 and 98 μmol heme, respectively. These figures are 3–5 times higher than those reported in the literature, calculated from increases in serum iron, bilirubin and COHb (without the use of a rebreathing system). When related to the total body heme (TBH) estimated with the CO dilution technique, the amount of “extra” heme metabolized after NA corresponded to 0.30% (range 0.26–0.32) of the TBH (a fourth of the total daily heme turnover or a third of the daily Hb heme catabolism).

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Carl-Bertil Laurell and His Outstanding Laboratory of Clinical Chemistry

Wollheim

2023

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On the Hyperbilirubinemic and Hypersideremic Action of Nicotinic Acid on Normal Subjects and on Patients with some Hematological Disorders

Cited by 11 publications

References 12 publications

The Effect of Desferrioxamine on Iron Metabolism in Man. II

The Effect of Desferrioxamine on Iron Metabolism in Man. II

Nicotinic Acid and the Endogenous Production of Carbon Monoxide

Carl-Bertil Laurell and His Outstanding Laboratory of Clinical Chemistry

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