On the Mechanism of the Antimycobacterial Activity of Isoniazid + Prothionamide + Dapsone (Isoprodian®)

Urbanczik, R

doi:10.1159/000237849

Cited by 3 publications

(2 citation statements)

References 15 publications

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“…Fur thermore, we are using currently DMSOcontaining media (l°/o) for testing the RMP susceptibility; should DMSO display such effects on the RMP resistance, then no RMP-resistant strains would have been de tected at all, which is not the case. Also, DMSO did not increase the leakage of small ions [16] from mycobacteria, suggesting that it was devoid of inducing alternations in the membrane permeability of the cells.…”

Section: Discussionmentioning

confidence: 93%

Antimycobacterial Activity of Isoniazid + Prothionamide + Dapsone against a Number of Randomly Selected ‘Wild’ Strains of Mycobacterium tuberculosis

Urbanczik¹

1980

Chemotherapy

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46 strains of Mycobacterium tuberculosis were studied as to their susceptibility to isoniazid (INH) or to INH + prothionamide (PTH) in the presence or absence of dapsone (DDS) by microdilution transfer plate technique. Synergy with DDS as defined by Berenbaum in 1978 was seen in 78% with INH and in 91% with INH + PTH. It concerned the minimal inhibitory concentration, whereas the minimal bactericidal concentration (MBC) was unaffected in the case of INH and it was increased in only 52% with INH + PTH. The latter MBC proportion mentioned would be decreased to roughly 16% accepting an only twofold decrease in the MBC as possibly due to dilution errors. The possible effect of dimethyl sulphoxide on the reported results is discussed.

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Section: Discussionmentioning

confidence: 93%

Antimycobacterial Activity of Isoniazid + Prothionamide + Dapsone against a Number of Randomly Selected ‘Wild’ Strains of Mycobacterium tuberculosis

Urbanczik¹

1980

Chemotherapy

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“…Besides, the synergistic effects of the drugs can be practically exploited. In this way, qualitatively new chemotherapeutical effects can be obtained [9,21,22,25,33,[36][37][38][39][40][45][46][47].…”

Section: Combinations and Alternative Medications Are Imperative In Lmentioning

confidence: 99%

New Forms of Multidrug Therapy for the Treatment of Leprosy

Freerksen¹,

Rosenfeld²,

Spannuth³

1989

Chemotherapy

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Since 1970, when the lifelong monotherapy with dapsone (DDS) in leprosy could be replaced by short-term combination therapy with rifampicin + isoniazid + protionamide-!-DDS (Isoprodian-RMP), chemotherapeutic research was faced with two problems: (1) to find alternative treatment regimens for cases of intolerance, and (2) to work out forms of therapy allowing a further reduction of the average treatment time of 2 years. The present paper describes the attempts made to find solutions to these problems. With two new combinations, alternatives have become available, and the average treatment time is shortened to 6 months. Both combinations are also effective in tuberculosis.

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