IMPORTANCE Previous anatomical and clinical studies have suggested that targeted restoration of the volume and distribution of fat compartments using appropriate cannula entry sites and injection planes is an excellent fat-grafting technique for facial contouring and hand rejuvenation. OBJECTIVE To perform subjective and objective evaluations of the safe and effective profile of the targeted fat-grafting technique for temporal hollowing augmentation. DESIGN, SETTING, AND PARTICIPANTS In a retrospective cohort study, a total of 96 consecutive patients with temporal hollowing were treated at the