On the possible role of qinghao acid in the biosynthesis of artemisinin

El‐Feraly, Farouk S.; Al-Meshal, I. A.; Al-Yahya, Mohammed A.; Hifnawy, Mohamed S.

doi:10.1016/s0031-9422(00)83739-5

Cited by 43 publications

(23 citation statements)

References 7 publications

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“…The stress of growing the plants under greenhouse conditions, particularly the unfavourable light conditions could be responsible for these various effects. Since artemisinic acid is the possible precursor (Martinerz and Staba, 1988;El-Feraly et al, 1986) of artemisinin and arteannuin B (Fig. 3), the greenhouse conditions appeared to be responsible, at least in part, for the conversion of artemisinic acid into these two metabolites.…”

Section: Resultsmentioning

confidence: 99%

“…Clones P2, and P16 were by far the highest producers and could be used for the commercial pro-clones PR, PZ2, P16, Pl, p27, PZ4, P2, Pz0 and Ply repre- duction of this important sesquiterpene. Artemisinic acid has been shown to be a useful chiral synthon for the synthesis of artemisinin and related compounds (Roth and Acton, 1985;El-Feraly et al, 1986;Jung et al, 1990). It is evident that clones P27, P2,, PI, and P19 represent the highest producing clones for the various sesquiterpenes under investigation (Fig.…”

Section: Resultsmentioning

confidence: 99%

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Selection and micropropagation of high artemisinin producing clones of Artemisia annua L.

Elhag

El-Domiaty

El‐Feraly

et al. 1992

Phytotherapy Research

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Selection and micropropagation of high artemisinin producing clones of Artemisia annua L.

Elhag

El-Domiaty

El‐Feraly

et al. 1992

Phytotherapy Research

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“…This compound is an intermediate on the biosynthetic pathway of artemisinin [51]. Via rearrangements, epoxidation and deoxygenation, followed by lactonization, arteannuinic acid may be converted into arteannuin B [52]. Arteannuin B is considered to be a late precursor of artemisinin [49].…”

Section: Biosynthesis Of Artemisinin and Related Compoundsmentioning

confidence: 99%

Artemisia annua L.: a source of novel antimalarial drugs

Woerdenbag

Lugt²,

Pras

1990

Pharmaceutisch Weekblad Scientific Edition

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Artemisia annua L. contains artemisinin, an endoperoxide sesquiterpene lactone, mainly in its leaves and inflorescences. This compound and a series of derivatives have attracted attention because of their potential value as antimalarial drugs. In this review a survey of the currently available literature data is given. It includes phytochemical aspects, such as constituents of A. annua, the artemisinin content during the development of the plant and its biosynthesis, isolation, analysis and stability. Total chemical synthesis of artemisinin is referred to, as well as structure-activity relationships of derivatives and simplified analogues. Pharmacological studies are summarized, including the mechanism of action, interaction of the antimalarial activity with other drugs, possible occurrence of resistance to artemisinin, clinical results, toxicological aspects, metabolism and pharmacokinetics. Finally, plant cell biotechnology is mentioned as a possible means to obtain plants and cell cultures with higher artemisinin contents, allowing an industrial production of pharmaceuticals containing this novel drug.

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“…But, the utility of artemisinin is limited in the biological systems due to its toxicity and water insolubility [5,6]. Studies on modification of artemisinin through biological [4,[7][8] and chemical methodologies [9,10] have been reported [11] to yield more effective and water soluble derivatives. Studies on quantitative structure activity relationship of artemisinin suggest that the structural modification of sesquiterpene lactone may yield desirable antimalarial analogues [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Biotransformation of Artemisinin Mediated through Fungal Strains for Obtaining Derivatives with Novel Activities

et al. 2009

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Artemisinin, a sesquiterpene lactone, is the active antimalarial constituent of Artemisia annua. Several fungal strains Saccharomyces cerevisiae, Aspergillus flavus, Aspergillus niger and Picchia pastoris were used to biotransform artemisinin. Among these strains, A. flavus was the only microorganism capable of transforming artemisinin to deoxyartemisinin in higher yields than the previous reports. The structure of deoxyartemisinin was elucidated by spectroscopy. Deoxyartemisinin showed antibacterial activity against Staphylococcus aureus, S. epidermidis and S. mutans at a minimum inhibitory concentration (MIC) of 1 mg/mL compared to artemisinin whose MIC was >2 mg/mL. Keywords

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On the possible role of qinghao acid in the biosynthesis of artemisinin

Cited by 43 publications

References 7 publications

Selection and micropropagation of high artemisinin producing clones of Artemisia annua L.

Selection and micropropagation of high artemisinin producing clones of Artemisia annua L.

Artemisia annua L.: a source of novel antimalarial drugs

Biotransformation of Artemisinin Mediated through Fungal Strains for Obtaining Derivatives with Novel Activities

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