One-carbon metabolism nutrient intake and the association between body mass index and urinary arsenic metabolites in adults in the Chihuahua cohort

Bommarito, Paige A.; Xu, Xichen; González-Horta, Carmen; Sánchez‐Ramírez, Blanca; Ballinas-Casarrubias, Lourdes; Luna, René Santos; Pérez, Susana; Ávila, Juan Eugenio Hernández; Garcı́a-Vargas, Gonzalo G.; Razo, Luz M. Del; Styblo, Mirek; Mendez, Michelle A.; Fry, Rebecca C.

doi:10.1016/j.envint.2018.12.004

Cited by 15 publications

(12 citation statements)

References 60 publications

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“…Vitamin B 12 intake correlated positively with urinary %MMA in the study by Heck et al [27]; other studies did not show such a relationship [24,28,30,32]. The study by Lopez-Carillo et al [28] also showed a positive association with urinary %DMA, which was not observed in the studies of other authors [27,30,32]. Only in two studies, the intake of this vitamin was negatively associated with %iAs in the urine [27,28].…”

Section: Nutrient Intake-ias Metabolismmentioning

confidence: 83%

“…In the study by Spratlen et al [30], vitamin B 2 intake was positively related with urinary %DMA, while no such relationship was shown in other studies [27,28,[31][32][33]. In contrast, a negative association with %iAs was shown in the study by Spratlen et al [30], while no such relationship was observed in other studies [27,28,[31][32][33]. There was no significant relationship between vitamin B 2 intake and urinary excretion of tAs [34].…”

Section: Nutrient Intake-ias Metabolismmentioning

confidence: 88%

“…Additionally, in several studies, there were no relationships [28,[31][32][33]. In the study by Spratlen et al [30], vitamin B 2 intake was positively related with urinary %DMA, while no such relationship was shown in other studies [27,28,[31][32][33]. In contrast, a negative association with %iAs was shown in the study by Spratlen et al [30], while no such relationship was observed in other studies [27,28,[31][32][33].…”

Section: Nutrient Intake-ias Metabolismmentioning

confidence: 90%

“…One study showed a positive association between vitamin B 2 intake and urinary %MMA [27], while another study showed a negative association with this form [30]. Additionally, in several studies, there were no relationships [28,[31][32][33]. In the study by Spratlen et al [30], vitamin B 2 intake was positively related with urinary %DMA, while no such relationship was shown in other studies [27,28,[31][32][33].…”

Section: Nutrient Intake-ias Metabolismmentioning

confidence: 95%

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Influence of Dietary Compounds on Arsenic Metabolism and Toxicity. Part II—Human Studies

Sijko

Kozłowska

2021

Toxics

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Exposure to various forms of arsenic (As), the source of which may be environmental as well as occupational exposure, is associated with many adverse health effects. Therefore, methods to reduce the adverse effects of As on the human body are being sought. Research in this area focuses, among other topics, on the dietary compounds that are involved in the metabolism of this element. Therefore, the aim of this review was to analyze the influence of methionine, betaine, choline, folic acid, vitamin B2, B6, B12 and zinc on the efficiency of inorganic As (iAs) metabolism and the reduction in the severity of the whole spectrum of disorders related to As exposure. In this review, which included 62 original papers (human studies) we present the current knowledge in the area. In human studies, these compounds (methionine, choline, folic acid, vitamin B2, B6, B12 and zinc) may increase iAs metabolism and reduce toxicity, whereas their deficiency may impair iAs metabolism and increase As toxicity. Taking into account the results of studies conducted in populations exposed to As, it is reasonable to carry out prophylactic activities. In particular nutritional education seems to be important and should be focused on informing people that an adequate intake of those dietary compounds potentially has a modulating effect on iAs metabolism, thus, reducing its adverse effects on the body.

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Section: Nutrient Intake-ias Metabolismmentioning

confidence: 83%

Section: Nutrient Intake-ias Metabolismmentioning

confidence: 88%

Section: Nutrient Intake-ias Metabolismmentioning

confidence: 90%

Section: Nutrient Intake-ias Metabolismmentioning

confidence: 95%

See 2 more Smart Citations

Influence of Dietary Compounds on Arsenic Metabolism and Toxicity. Part II—Human Studies

Sijko

Kozłowska

2021

Toxics

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“…Epidemiological studies evaluating the relationship between BMI and the distribution of urinary As metabolites found a positive association of BMI with DMA% and a negative association with MMA% [ 112 , 113 , 114 , 115 , 116 ]. Conversely, our results did not show any association between BMI and urinary As metabolite levels, a findings that is instead in accordance with what reported by Bae et al [ 95 ].…”

Section: Discussionmentioning

confidence: 99%

Factors Affecting Arsenic Methylation in Contaminated Italian Areas

Bustaffa

Gorini

Bianchi

et al. 2020

IJERPH

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Chronic arsenic (As) exposure is a critical public health issue. The As metabolism can be influenced by many factors. The objective of this study is to verify if these factors influence As metabolism in four Italian areas affected by As pollution. Descriptive analyses were conducted on 271 subjects aged 20–49 in order to assess the effect of each factor considered on As methylation. Percentages of metabolites of As in urine, primary and secondary methylation indexes were calculated as indicators for metabolic capacity. The results indicate that women have a better methylation capacity (MC) than men, and drinking As-contaminated water from public aqueducts is associated with poorer MC, especially in areas with natural As pollution. In areas with anthropogenic As pollution occupational exposure is associated with a higher MC while smoking with a poorer MC. Dietary habits and genetic characteristics are probably implicated in As metabolism. BMI, alcohol consumption and polymorphism of the AS3MT gene seem not to influence As MC. Arsenic metabolism may be affected by various factors and in order to achieve a comprehensive risk assessment of As-associated disease, it is crucial to understand how these factors contribute to differences in As metabolism.

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Provision of folic acid for reducing arsenic toxicity in arsenic-exposed children and adults

Bae

Kamynina

Guetterman

et al. 2021

Cochrane Database of Systematic Reviews

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One-carbon metabolism nutrient intake and the association between body mass index and urinary arsenic metabolites in adults in the Chihuahua cohort

Cited by 15 publications

References 60 publications

Influence of Dietary Compounds on Arsenic Metabolism and Toxicity. Part II—Human Studies

Influence of Dietary Compounds on Arsenic Metabolism and Toxicity. Part II—Human Studies

Factors Affecting Arsenic Methylation in Contaminated Italian Areas

Provision of folic acid for reducing arsenic toxicity in arsenic-exposed children and adults

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