One-flow upscaling neutralization of an organophosphonate-derived pesticide/nerve agent simulant to value-added chemicals in a novel Teflon microreactor platform

Abstract

Synthesizing value-added products from chemical warfare agents is a concept well beyond the usual notion of simply neutralizing the agents.

Modular Flow Reactors for Valorization of Kraft Lignin and Low‐Voltage Hydrogen Production

“…However, the fluidic systems can further facilitate the overall process owing to their unique advantages for effective mass and heat transfer. [ 24 , 25 , 26 , 27 ]…”

Will the next generation of chemical plants be in miniaturized flow reactors?

“…70,71 Noteworthy, the treatment of methyl paraoxon in a concatenated sequence (basic hydrolysis/reduction/acylation) allows the cleavage of the side chain of this toxic pesticide and its transformation into the API paracetamol. 71 Scheme 5. Safe flow neutralization of CWA and pesticides.…”

Soft detoxification of chemical warfare agent simulants and pesticides under pressure

“…21 Importantly, all these methods are not general and each focuses on a specific class of compounds: yperite, 16,17,19 V-series OPNAs, 21 sulfur-containing CWAs, 18 or Paraoxon. 20…”

“…Recently, continuous flow reactors have attracted attention as an alternative to classical batch chemistry to ensure rapid and selective neutralization of such harmful chemicals with oxidizing agents. [16][17][18][19] Moreover, successful neutralisation by direct introduction of an aqueous solution of sodium hydroxide in the flow system has also been reported, 20 whereas a 3D-printed chemical generator of lithium ethanolate has been later reported as a reliable method. 21 Importantly, all these methods are not general and each focuses on a specific class of compounds: yperite, 16,17,19 V-series OPNAs, 21 sulfur-containing CWAs, 18 or Paraoxon.…”

“…21 Importantly, all these methods are not general and each focuses on a specific class of compounds: yperite, 16,17,19 V-series OPNAs, 21 sulfur-containing CWAs, 18 or Paraoxon. 20 Regarding alternative technological tools for chemistry, hyperbaric reactors (i.e. affording a pressure of several thousand bars) exhibit several features of great interest in terms of the decomposition of these toxic chemicals.…”