One pot glucose detection by [FeIII(biuret-amide)] immobilized on mesoporous silica nanoparticles: an efficient HRP mimic

Abstract

An [Fe(III)(biuret-amide)] complex has been immobilized onto mesoporous silica nanoparticles via Cu(I) catalyzed azide-alkyne click chemistry. This hybrid material functions as an efficient peroxidase mimic and was successfully used for the quantitative determination of hydrogen peroxide and glucose via a one-pot colorimetric assay.

Immobilization of Molecular Catalysts for Enhanced Redox Catalysis

“…An [Fe III (biuret‐amide)] complex was also immobilized on mesoporous SiO 2 NPs (mesoporous silica nanoparticles; MSNs) via Cu I ‐catalyzed azide‐alkyne click chemistry . The azide functionalized SiO 2 NP was prepared by one‐pot co‐condensation of tetraethyl orthosilicate (TEOS) with 3‐azidopropyl triethoxysilane (AzPTES) in the molar ratio of 99:1 as shown in Scheme .…”

“…[185] The Fe-MSN hybrid catalyst acted as an efficient peroxidase mimic, being successfully utilized for the quantitative determination of H 2 O 2 and glucose via ao ne-pot colorimetrica ssay. [185] The catalytic activity of Fe-MSNw as ca. 1000 times higher than that of natural HRP and 100 times highert han those of most HRP mimics based on metal/metal oxide NPsreported to date.…”

Reactivity and Operational Stability of N‐Tailed TAMLs through Kinetic Studies of the Catalyzed Oxidation of Orange II by H2O2: Synthesis and X‐ray Structure of an N‐Phenyl TAML

“…Recently,anew (fifth) generation of TAML activators (3)h as been introduced [6] ande xamined in several applications. [6][7][8][9] Catalysts 3 feature an NÀRf or CR 2 substitution in the "tail" part of the prototypical activators 1.T his substitution introduces ap air of p electrons into the six-membered ring "tail" and reduces steric bulk around the iron actives itea ssociated with the boat conformation of the six-membered ring of 1. [10] Additionally,t he biuret nitrogen p lone pair of 3 could stabilize planarity in the six-membered ring to hindert he known intramolecular suicidald egradation of the ligand system of 1.…”

Bis‐clickable Mesoporous Silica Nanoparticles: Straightforward Preparation of Light‐Actuated Nanomachines for Controlled Drug Delivery with Active Targeting

“…Hence, the pores were capped with supramolecular groups containing cyclodextrin DNA or rotaxanes by anchoring them to the external surface of the nanoparticles using the CuAAC click reaction. Later on, a peroxidase mimic featuring an iron‐based voluminous group was successfully click‐grafted and used for biosensing . Bifunctional MSNs were then produced from bis‐clickable MSN, functionalizable either by two different click reactions (CuAAC and thiol‐alkene coupling or CuAAC then nitroxide exchange) or by successive CuAAC couplings on azide and alkyne functions homogeneously implemented in the MSNs by co‐condensation .…”

“…Later on, ap eroxidase mimic featuring an iron-based voluminous group was successfully click-grafted and used for biosensing. [46] Bifunctional MSNs were then produced from bis-clickable MSN, functionalizable either by two different click reactions (CuAACa nd thiol-alkene coupling or CuAAC then nitroxide exchange) [47,48] or by successive CuAACc ouplings on azide and alkyne functions homogeneously implemented in the MSNs by co-condensation. [49] Indeed, we have recently reported the controlled design of CuAAC bis-clickable nanoparticles which can be functionalized with two communicating functionalitiest oc ontrollably release drugs.…”