One-pot solventless preparation of PEGylated black phosphorus nanoparticles for photoacoustic imaging and photothermal therapy of cancer

Sun, Changzheng; Wen, Ling; Zeng, Jianfeng; Wang, Yong; Sun, Qiao; Deng, Lijuan; Zhao, Chongjun; Li, Zhen

doi:10.1016/j.biomaterials.2016.03.022

Cited by 423 publications

(310 citation statements)

References 53 publications

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“…Initially, the starting RP powder has two broad peaks at 2θ=30° and 55°, suggesting the amorphous structure of RP, which is consistent with previously reported amorphous RP [60,69,70]. The TEM electron diffraction pattern shows a diffuse ring of RP ( Fig.…”

Section: Resultssupporting

confidence: 76%

“…The two distinct peaks at 129.3 eV and 130.2 eV in the P2p spectrum are assigned to the 2p3/2 and 2p1/2 orbitals of zero-valent phosphorous (P 0 ), respectively. The broad peak at 133.9 eV is attributed to oxidized phosphorus (i.e., P 5+ ), indicating the partial oxidization of P0 during sample preparation and purification, as the surface of BP nanostructures is sensitive to oxygen and moisture [70].…”

Section: Resultsmentioning

confidence: 99%

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Black phosphorus as a new lubricant

2018

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Abstract:In recent years, a new 2D-layered material-black phosphorus (BP)-has been a rising star after the era of graphene owing to its high charge carrier mobility, tunable direct bandgap and unique in-plane anisotropic structure. With the development of the synthesis and modification methods of BP, its extensive applications, e.g., transistors, batteries and optoelectronics have emerged. In order to explore its full potential, research into the tribological properties of BP 2D-layered materials such as lubrication additives and fillers in self-lubricating composite materials would be not only of high scientific value but also of practical significance. In this work, recent advances on the friction and lubrication properties of BP nanosheets made by our group, including the micro-friction properties, the lubrication properties of BP nanosheets as water-based and oil-based lubrication additives, and the friction and wear of BP/PVDF composites will be presented. Finally, the future challenges and opportunities in the use of BP materials as lubricants will be discussed.

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Section: Resultssupporting

confidence: 76%

Section: Resultsmentioning

confidence: 99%

Black phosphorus as a new lubricant

2018

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“…BP nanosheets are a type of 2D nanomaterials with unique properties such as a tunable band gap, high NIR absorption, and high photothermal conversion efficiency 33, 34, 35, 36, 37, 38, 39, 40. As an inorganic nanoagent, BP nanosheets are attractive due to the inherent biocompatibility since phosphorus is a vital element, especially in bones, making up about 1% of the human body weight 41, 42, 43.…”

Section: Introductionmentioning

confidence: 99%

Black‐Phosphorus‐Incorporated Hydrogel as a Sprayable and Biodegradable Photothermal Platform for Postsurgical Treatment of Cancer

et al. 2018

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Photothermal therapy (PTT) is a fledgling therapeutic strategy for cancer treatment with minimal invasiveness but clinical adoption has been stifled by concerns such as insufficient biodegradability of the PTT agents and lack of an efficient delivery system. Here, black phosphorus (BP) nanosheets are incorporated with a thermosensitive hydrogel [poly(d,l‐lactide)‐poly(ethylene glycol)‐poly(d,l‐lactide) (PDLLA‐PEG‐PDLLA: PLEL)] to produce a new PTT system for postoperative treatment of cancer. The BP@PLEL hydrogel exhibits excellent near infrared (NIR) photothermal performance and a rapid NIR‐induced sol–gel transition as well as good biodegradability and biocompatibility in vitro and in vivo. Based on these merits, an in vivo PTT postoperative treatment strategy is established. Under NIR irradiation, the sprayed BP@PLEL hydrogel enables rapid gelation forming a gelled membrane on wounds and offers high PTT efficacy to eliminate residual tumor tissues after tumor removal surgery. Furthermore, the good photothermal antibacterial performance prevents infection and this efficient and biodegradable PTT system is very promising in postoperative treatment of cancer.

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“…Recently, black phosphorus (BP) nanomaterials with broad absorption in both UV and NIR regions, due to its excellent biodegradable property, has been used in PAI 75. Compared with other inorganic PA contrast agents, BP nanomaterials are composed of element phosphorus without any heavy metals.…”

Section: Pa Contrast Agentsmentioning

confidence: 99%

Recent Advances in Photoacoustic Imaging for Deep-Tissue Biomedical Applications

et al. 2016

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Photoacoustic imaging (PAI), a novel imaging modality based on photoacoustic effect, shows great promise in biomedical applications. By converting pulsed laser excitation into ultrasonic emission, PAI combines the advantages of optical imaging and ultrasound imaging, which benefits rich contrast, high resolution and deep tissue penetration. In this paper, we introduced recent advances of contrast agents, applications, and signal enhancement strategies for PAI. The PA contrast agents were categorized by their components, mainly including inorganic and organic PA contrast agents. The applications of PAI were summarized as follows: deep tumor imaging, therapeutic responses monitoring, metabolic imaging, pH detection, enzyme detection, reactive oxygen species (ROS) detection, metal ions detection, and so on. The enhancement strategies of PA signals were highlighted. In the end, we elaborated on the challenges and provided perspectives of PAI for deep-tissue biomedical applications.

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One-pot solventless preparation of PEGylated black phosphorus nanoparticles for photoacoustic imaging and photothermal therapy of cancer

Cited by 423 publications

References 53 publications

Black phosphorus as a new lubricant

Black phosphorus as a new lubricant

Black‐Phosphorus‐Incorporated Hydrogel as a Sprayable and Biodegradable Photothermal Platform for Postsurgical Treatment of Cancer

Recent Advances in Photoacoustic Imaging for Deep-Tissue Biomedical Applications

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