One-pot synthesis of chlorhexidine-templated biodegradable mesoporous organosilica nanoantiseptics

He, Yan; Zhang, Yue; Sun, Madi; Yang, Chao; Zheng, Xiao; Shi, Chengxin; Chang, Zhimin; Wang, Zheng; Chen, Jinying; Pei, Shuchen; Dong, Wen‐Fei; Shao, Dan; She, Junjun

doi:10.1016/j.colsurfb.2019.110653

Cited by 14 publications

(7 citation statements)

References 41 publications

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“…Nevertheless, the presence of chlorhexidine in the supernatant indicates its release from CHX-DS@SBA-15 which supports its potential use as an advanced functional material for drug delivery applications. 22,28…”

Section: Paper Dalton Transactionsmentioning

confidence: 99%

“…[19][20][21] More recently, CHX has been used as a template to functionalize mesoporous organosilica nanoparticles which possess equal antibacterial properties to free CHX. 22 Previous work has demonstrated that SDS significantly reduces the in vivo antiplaque efficacy of CHX, but there is a lack of evidence for the mechanistic explanation of this phenomenon. 23 Controversial discussions amongst researchers have been ongoing for many years regarding the antibacterial efficacy of CHX in the presence of SDS, and whether SDS inhibits CHX efficacy; however, no crystal structure has been resolved to conclude the debate.…”

Section: Introductionmentioning

confidence: 99%

“…19–21 More recently, CHX has been used as a template to functionalize mesoporous organosilica nanoparticles which possess equal antibacterial properties to free CHX. 22…”

Section: Introductionmentioning

confidence: 99%

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Novel anionic surfactant-modified chlorhexidine and its potent antimicrobial properties

Muneeswaran,

Teoman,

Wang

et al. 2024

Dalton Trans.

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Section: Paper Dalton Transactionsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Novel anionic surfactant-modified chlorhexidine and its potent antimicrobial properties

Muneeswaran,

Teoman,

Wang

et al. 2024

Dalton Trans.

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“…Apart from chemical modifications, which are aimed at modifying the interactions between cargoes and carriers, another interesting possibility is to modify the dissolution rates of the carrier itself to enhance drug release. This strategy was successfully employed by He et al, who prepared mesoporous organosilica nanoparticles (MONs) bridged with tetrasulfide bonds with chlorhexidine as the template 40 in order to prepare a nanosystem able to dissolve in metabolically active microenvironments. As a result, their chlorhexidine-loaded MONs had a superior release of the antibiotic under the presence of glutathione (GSH) that achieved complete drug release within four days.…”

Section: Delivery Of Antibiotic Compoundsmentioning

confidence: 99%

Recent Advances Toward the Use of Mesoporous Silica Nanoparticles for the Treatment of Bacterial Infections

Castillo

2021

IJN

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It is a fact that the use of antibiotics is inducing a growing resistance on bacteria. This situation is not only the consequence of a drugs’ misuse, but a direct consequence of a widespread and continuous use. Current studies suggest that this effect could be reversed by using abandoned antibiotics to which bacteria have lost their resistance, but this is only a temporary solution that in near future would lead to new resistance problems. Fortunately, current nanotechnology offers a new life for old and new antibiotics, which could have significantly different pharmacokinetics when properly delivered; enabling new routes able to bypass acquired resistances. In this contribution, we will focus on the use of porous silica nanoparticles as functional carriers for the delivery of antibiotics and biocides in combination with additional features like membrane sensitizing and heavy metal-driven metabolic-disrupting therapies as two of the most interesting combination therapies.

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“…As an alternative, mesoporous organosilica NPs (MONs) were employed to achieve stimuli-responsive degradation and drug release via employing stimulus-responsive cleavable bonds into the silica framework. [28][29][30][31][32][33][34][35][36][37][38] Our group developed a facile method to fabricate nanosilver-decorated biodegradable MONs (Ag-MONs) with matrix-degradation property, leading to controlled silver ions release against bacteria 39 With these findings in mind, we hypothesized that Ag-MONs may be selected as an ideal system for GEN delivery, which might achieve synergistic activity against resistant bacteria and less side effects via stimuliresponsive drug release.…”

Section: Introductionmentioning

confidence: 99%

Nanosilver-Decorated Biodegradable Mesoporous Organosilica Nanoparticles for GSH-Responsive Gentamicin Release and Synergistic Treatment of Antibiotic-Resistant Bacteria

Chen

et al. 2021

IJN

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Antibiotic-resistant bacteria are pathogens that have emerged as a serious public health risk. Thus, there is an urgent need to develop a new generation of anti-bacterial materials to kill antibiotic-resistant bacteria. Methods: Nanosilver-decorated mesoporous organosilica nanoparticles (Ag-MONs) were fabricated for co-delivery of gentamicin (GEN) and nanosilver. After investigating the glutathione (GSH)-responsive matrix degradation and controlled release of both GEN and silver ions, the anti-bacterial activities of Ag-MONs@GEN were systematically determined against several antibiotic-susceptible and antibiotic-resistant bacteria including Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Enterococcus faecalis. Furthermore, the cytotoxic profiles of Ag-MONs@GEN were evaluated. Results: The GEN-loaded nanoplatform (Ag-MONs@GEN) showed glutathione-responsive matrix degradation, resulting in the simultaneous controlled release of GEN and silver ions. Ag-MONs@GEN exhibited excellent anti-bacterial activities than Ag-MONs and GEN alone via inducing ROS generation, especially enhancing synergetic effects against four antibioticresistant bacteria including Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Enterococcus faecalis. Moreover, the IC 50 values of Ag-MONs@GEN in L929 and HUVECs cells were 313.6 ± 15.9 and 295.7 ± 12.3 μg/mL, respectively, which were much higher than their corresponding minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values. Conclusion:Our study advanced the development of Ag-MONs@GEN for the synergistic and safe treatment of antibiotic-resistant bacteria.

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One-pot synthesis of chlorhexidine-templated biodegradable mesoporous organosilica nanoantiseptics

Cited by 14 publications

References 41 publications

Novel anionic surfactant-modified chlorhexidine and its potent antimicrobial properties

Novel anionic surfactant-modified chlorhexidine and its potent antimicrobial properties

Recent Advances Toward the Use of Mesoporous Silica Nanoparticles for the Treatment of Bacterial Infections

Nanosilver-Decorated Biodegradable Mesoporous Organosilica Nanoparticles for GSH-Responsive Gentamicin Release and Synergistic Treatment of Antibiotic-Resistant Bacteria

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