One-step prepared nano-in-micro microcapsule delivery vehicle with sequential burst–sustained drug release for the targeted treatment of inflammatory bowel disease

Abstract

Orally targeted drug delivery for colonic diseases has shown great importance because it can avoid the conventional administration of high drug doses, which usually expose patients to serious systemic toxicity....

Oxidative Stress and Antioxidant Nanotherapeutic Approaches for Inflammatory Bowel Disease

“…The utility of polyphenol in nano-formulations aims to improve its solubility, activity, and stability, making the compound therapeutically more effective without adverse effects. Many nano-encapsulated polyphenols (curcumin, resveratrol, berberin, epigallocatechin gallate (EGCG), tannic acid, rosmarin acid, oleuropein, and ginsenoside) have recently been proved to have anti-inflammatory properties and have an important role in the management of IBD [ 10 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 67 ]. For the same reason, the polyphenol-rich extracts such as grape seed extract, green tea extract, and lycin barbarum extract have the potential to treat intrinsic inflammation as well [ 66 , 68 , 69 , 70 ].…”

Charge-reversible and biodegradable chitosan-based microgels for lysozyme-triggered release of vancomycin

“…However, due to a lack of a targeted delivery capability and unsatisfactory bioavailability, the administration of high-dose agents is necessary to maintain an efficient drug concentration in the inflamed intestinal region, which will also lead to serious side effects and drug resistance [9] , [10] , [11] . Although direct rectal administration may provide an efficient drug concentration in targeted sites, this method is always accompanied by injury and severe pain [12] , [13] . Moreover, oral administration also increases drug efficacy and reduces side effects, but the drug always encounters the harsh acidic gastric environment, which alters stability and pharmaceutical effects [14] , [15] .…”

Versatile Fabrication of Polymer Microcapsules with Controlled Shell Composition and Tunable Performance via Photopolymerization

“…Microcapsules have been widely used in various fields such as microreactors, , thermal energy storage, , drug delivery, , self-healing, − and self-reporting. , The performance of microcapsules is closely related to its unique core–shell structure. Especially in practical applications, microcapsules are often faced with harsh operating conditions and specific response environments, , such as high-speed stirring, solvent immersion, and heating, which put forward higher requirements for the permeability, mechanical properties, and thermal stability of microcapsules, and these properties are closely related to the microcapsule shell structure.…”