Online monitoring of myocardial bioprosthesis for cardiac repair

Prat‐Vidal, Cristina; Gálvez‐Montón, Carolina; Puig-Sanvicens, Verónica; Sanchez, Benjamin; Dı́az-Güemes, Idoia; Bogónez-Franco, Paco; Perea‐Gil, Isaac; Casas-Solà, Anna; Roura, Santiago; Llucià‐Valldeperas, Aida; Soler‐Botija, Carolina; Sánchez‐Margallo, Francisco M.; Semino, Carlos E.; Bardia, Ramon Bragós; Bayés‐Genís, Antoni

doi:10.1016/j.ijcard.2014.04.181

Cited by 35 publications

(54 citation statements)

References 32 publications

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“…Furthermore, peptide hydrogels comprising neonatal cardiomyocytes were transplanted into the myocardium, resulting in not only good cell survival, but also the increase in endogenous cell recruitment. 134 Polycaprolactone methacryloyloxyethyl ester were lled with peptide hydrogels (PuraMatrix™) to synthesize bioactive hybrid implants for seeding subcutaneous adipose tissue-derived progenitor cells (subATDPCs). 42 In another study, selected mesenchymal stem cells (SMSCs) isolated from bone marrow of adult male rats were cultured in RADA16-II peptide nanober scaffolds, revealing good growth, survival and differentiation of SMSCs.…”

Section: Combination Of Peptide Hydrogels and Cellsmentioning

confidence: 99%

Fabrication of self-assembling peptide nanofiber hydrogels for myocardial repair

Yuan

et al. 2014

RSC Adv.

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Myocardial infarction (MI) has become widely spread in clinical medicine, and results in massive loss of myocardium, ventricular remodeling and ultimately heart failure. Many strategies for repairing injured myocardium are under extensive investigation with some early encouraging effects, but cannot effectively prevent disease progression and heart failure. Cardiac tissue engineering has emerged as an increasingly important approach to repair infarcted myocardium. Self-assembling peptide nanofiber hydrogels are regarded as tailored biomaterial scaffolds with the aim to develop cardiac tissue engineering. Their fabrication is based on the principle of molecular self-assembly which allows tailoring of the biological features (e.g. modification with functional motifs and controlled release of signal molecules) of supramolecular structures for cell behaviors and tissue regeneration. This review will outline the potential of combinational treatments of peptide nanofiber hydrogels with cells, growth factors, or both together in myocardial repair.

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Section: Combination Of Peptide Hydrogels and Cellsmentioning

confidence: 99%

Fabrication of self-assembling peptide nanofiber hydrogels for myocardial repair

Yuan

et al. 2014

RSC Adv.

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“…In this context, different natural and synthetic biocompatible and biodegradable materials (Figure 1) have appeared in the experimental set. -Natural materials such as fibrin [75], chitosan [76], alginate [10] or collagen mixtures [77] [110]. (I) Immunofluorescence against βIII tubulin (green), cTnI (white), and elastin (red) labelled nerve fibres (arrows), M, myocardium and P, patch, respectively [111].…”

Section: Artificial Cardiac Tissuementioning

confidence: 99%

“…In vitro studies demonstrate that pericardial-derived ECM allows cell survival, growth and attachment induced pluripotent stem cells (iPSCs)-derived cardiomyocytes and MSCs [109], and also facilitates differentiation of progenitor cells derived from adipose [110] and cardiac [108] tissue towards endothelial or cardiac cell lineage, respectively. Furthermore, decellularised human pericardium embedded with self-assembling peptide RAD16-I and adipose tissue--derived progenitor cells (ATDPCs) increases scaffold vascularisation and reduces infarct size one month after implantation in the swine MI model ( Figure 2 E-G) [110].…”

Section: Extracellular Matrix Derived From Natural Tissuesmentioning

confidence: 99%

“…Furthermore, decellularised human pericardium embedded with self-assembling peptide RAD16-I and adipose tissue--derived progenitor cells (ATDPCs) increases scaffold vascularisation and reduces infarct size one month after implantation in the swine MI model ( Figure 2 E-G) [110]. Hence, although the pericardial matrix is not an exact match to myocardial ECM, it favours cell retention and cardiac differentiation, offering an additional autologous / allogeneic therapeutic option for cardiac repair.…”

Section: Extracellular Matrix Derived From Natural Tissuesmentioning

confidence: 99%

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Materials for cardiac tissue engineering

Gálvez‐Montón¹,

Soler‐Botija²,

Roura³

et al. 2016

Nanomaterials and Regenerative Medicine

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“…Prat‐Vidal et al previously reported preliminary data on a novel engineered bioactive impedance graft (EBIG) comprising a scaffold of decellularized human pericardium, green fluorescent protein (GFP)‐labeled porcine adipose tissue‐derived progenitor cells (pATPCs), and an electrical impedance spectroscopy (EIS) monitoring system . The functional impact of EBIG in a preclinical model of MI and scar maturation characteristics remains unknown.…”

Section: Introductionmentioning

confidence: 99%

Noninvasive Assessment of an Engineered Bioactive Graft in Myocardial Infarction: Impact on Cardiac Function and Scar Healing

Gálvez‐Montón

Bragós

Soler‐Botija

et al. 2016

Stem Cells Translational Medicine

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Cardiac tissue engineering, which combines cells and biomaterials, is promising for limiting the sequelae of myocardial infarction (MI). We assessed myocardial function and scar evolution after implanting an engineered bioactive impedance graft (EBIG) in a swine MI model. The EBIG comprises a scaffold of decellularized human pericardium, green fluorescent protein‐labeled porcine adipose tissue‐derived progenitor cells (pATPCs), and a customized‐design electrical impedance spectroscopy (EIS) monitoring system. Cardiac function was evaluated noninvasively by using magnetic resonance imaging (MRI). Scar healing was evaluated by using the EIS system within the implanted graft. Additionally, infarct size, fibrosis, and inflammation were explored by histopathology. Upon sacrifice 1 month after the intervention, MRI detected a significant improvement in left ventricular ejection fraction (7.5% ± 4.9% vs. 1.4% ± 3.7%; p = .038) and stroke volume (11.5 ± 5.9 ml vs. 3 ± 4.5 ml; p = .019) in EBIG‐treated animals. Noninvasive EIS data analysis showed differences in both impedance magnitude ratio (−0.02 ± 0.04 per day vs. −0.48 ± 0.07 per day; p = .002) and phase angle slope (−0.18° ± 0.24° per day vs. −3.52° ± 0.84° per day; p = .004) in EBIG compared with control animals. Moreover, in EBIG‐treated animals, the infarct size was 48% smaller (3.4% ± 0.6% vs. 6.5% ± 1%; p = .015), less inflammation was found by means of CD25+ lymphocytes (0.65 ± 0.12 vs. 1.26 ± 0.2; p = .006), and a lower collagen I/III ratio was detected (0.49 ± 0.06 vs. 1.66 ± 0.5; p = .019). An EBIG composed of acellular pericardium refilled with pATPCs significantly reduced infarct size and improved cardiac function in a preclinical model of MI. Noninvasive EIS monitoring was useful for tracking differential scar healing in EBIG‐treated animals, which was confirmed by less inflammation and altered collagen deposit. Stem Cells Translational Medicine 2017;6:647–655

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Online monitoring of myocardial bioprosthesis for cardiac repair

Cited by 35 publications

References 32 publications

Fabrication of self-assembling peptide nanofiber hydrogels for myocardial repair

Fabrication of self-assembling peptide nanofiber hydrogels for myocardial repair

Materials for cardiac tissue engineering

Noninvasive Assessment of an Engineered Bioactive Graft in Myocardial Infarction: Impact on Cardiac Function and Scar Healing

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