Online resistance monitoring during autometallographic enhancement of colloidal Au labels for DNA analysis

Dießel, E.; Grothe, Klaus; Siebert, Hans-Michael; Warner, Brian D.; Burmeister, Jens

doi:10.1016/j.bios.2003.11.013

Cited by 28 publications

(16 citation statements)

References 14 publications

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“…733 Additionally Diessel and coworkers have further demonstrated the utility of this strategy for the detection of single-nucleotide polymorphism. 734 …”

Section: Electrical and Electrochemical Sensingmentioning

confidence: 99%

Gold Nanoparticles in Chemical and Biological Sensing

et al. 2012

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“…733 Additionally Diessel and coworkers have further demonstrated the utility of this strategy for the detection of single-nucleotide polymorphism. 734 …”

Section: Electrical and Electrochemical Sensingmentioning

confidence: 99%

Gold Nanoparticles in Chemical and Biological Sensing

et al. 2012

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“…A self‐contained microanalyzer was used for parallel readout of the entire array, indicating great promise for point‐of‐care applications. Applicability of such resistive measurements for the detection of single‐nucleotide polymorphism (SNP) was illustrated by Diesel and co‐workers 41. Factors influencing such silverenhanced bioanalyte detection were discussed by Moller et al 42…”

Section: Nanoparticle‐enhanced Bioelectronic Assaysmentioning

confidence: 99%

Nanomaterial‐Based Amplified Transduction of Biomolecular Interactions

Wang

2005

Small

410

232

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This article reviews progress in the development of nanomaterials for amplified biosensing and discusses different nanomaterial-based bioamplification strategies. Signal amplification has attracted considerable attention for ultrasensitive detection of disease markers and biothreat agents. The emergence of nanotechnology is opening new horizons for highly sensitive bioaffinity and biocatalytic assays and for novel biosensor protocols that employ electronic, optical, or microgravimetric signal transduction. Nucleic acids and antibodies functionalized with metal or semiconductor nanoparticles have been employed as amplifying tags for the detection of DNA and proteins. The coupling of different nanomaterial-based amplification platforms and amplification processes dramatically enhances the intensity of the analytical signal and leads to ultrasensitive bioassays. The successful realization of the new nanoparticle-based signal amplification strategies requires proper attention to nonspecific adsorption issues. The implications of such nanoscale materials on amplified biodetection protocols and on the development of modern biosensors are discussed.

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“…The particles turned out to grow linearly dependent on their seed size and the applied enhancement solutions differed considerably in their enhancement intensity and specificity. Another approach has been demonstrated by on-line DC resistance monitoring, which were performed during the autometallographic enhancement process of gold particle-labeled analytes [21]. Beside the described DC approaches, AC capacitance measurements offer a further method of detecting an electrical signal, which does not necessarily requires a fully conductive structure between the electrodes [22].…”

Section: Electrical Detectionmentioning

confidence: 99%

DNA-conjugated metal nanoparticle for bioanalytics, nanophotonics, and nanoelectronics

Fritzsche

Csáki

Möller

et al. 2007

BioMEMS and Nanotechnology III

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Metal (especially gold) nanoparticles exhibit unique electronic, optical, and catalytic properties. In order to utilize these properties, an integration of the particles into technical setups such as a chip surface is helpful. We develop techniques to use (bio) molecular tools in order to address and control the positioning of particles on microstructured chips. These techniques are utilized for novel DNA detection schemes using optical or electrical principles. Plasmonic properties of the particles and the combination of nano-apertures with particles are promising fields for further bioanalytical developments.On the other hand, methods for defined positioning of single molecules or molecular constructs in parallel approaches are under development, in order to provide needed defined nanostructures for applications in nanoelectronics. Connecting DNA with nanoparticles, metallization of DNA or positioning of individual DNA-structures over microstructured electrode gap including subsequent metal particle binding are important steps in this direction. The utilization of (bio) molecular tools and principles based on highly specific binding and self-assembly represent a promising development in order to realize novel nanoparticle-based devices for bioanalytics, nano-optics andelectronics.

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Online resistance monitoring during autometallographic enhancement of colloidal Au labels for DNA analysis

Cited by 28 publications

References 14 publications

Gold Nanoparticles in Chemical and Biological Sensing

Gold Nanoparticles in Chemical and Biological Sensing

Nanomaterial‐Based Amplified Transduction of Biomolecular Interactions

DNA-conjugated metal nanoparticle for bioanalytics, nanophotonics, and nanoelectronics

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