Ontogeny of B and T cells in sea bass (Dicentrarchus labrax, L.)

Santos, Nuno M.S dos; Romano, Nicla; Sousa, Maria de; Ellis, A.E.; Rombout, J.H.W.M.

doi:10.1006/fsim.2000.0273

Cited by 61 publications

(53 citation statements)

References 34 publications

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“…All these results strongly indicated that the maturation of adaptive immune system depends more on age than body size in mandarin fish. Although this was contrary with previous popular views, it was supported by researches in sea bass, in which direct comparison of the Ig level between the faster-and slowergrowing fish from the same spawn did not show obvious difference (Breuil et al, 1997;dos Santos et al, 2000). In addition, in this study, no IgM-producing cells appeared before 20 dph suggesting that innate immune mechanisms or maternal immunoglobulin may provide protection against pathogens during the early stage of development in mandarin fish; so do tilapia, Oreochromis mossambicus (Takemura and Takano, 1997).…”

Section: Discussionmentioning

confidence: 56%

Ontogeny of IgM-producing cells in the mandarin fish Siniperca chuatsi identified by in situ hybridisation

Tian

Xie

Zhang

et al. 2009

Veterinary Immunology and Immunopathology

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Section: Discussionmentioning

confidence: 56%

Ontogeny of IgM-producing cells in the mandarin fish Siniperca chuatsi identified by in situ hybridisation

Tian

Xie

Zhang

et al. 2009

Veterinary Immunology and Immunopathology

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“…At 3 months, when lymphocytes are evident in the spleen, incipient ellipsoids appear that are involved in antigen trapping. A similar pattern of development has been described for the spleen of other teleosts, such as the salmon [12], the sea bass [17] and the channel catfish [31].…”

Section: Histogenesis Of the Lymphoid Organs And Origins Of T-and B-lmentioning

confidence: 52%

Ontogeny of the immune system of fish

Zapata

Diez

Cejalvo

et al. 2006

Fish & Shellfish Immunology

572

293

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“…Progenitor B cells generated in this site undergo several developmental stages, resulting in (im)mature B cells with membrane Ig on their cell surface (15,16). As in mammalian bone marrow, anterior kidney also stores Ig-secreting longlived plasma cells (17,18).…”

mentioning

confidence: 99%

B Cell Heterogeneity in the Teleost Kidney: Evidence for a Maturation Gradient from Anterior to Posterior Kidney

Zwollo

Cole

Bromage

et al. 2005

The Journal of Immunology

214

192

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The fish immune system is quite different from the mammalian system because the anterior kidney forms the main site for hematopoiesis in this species. Using transcription factor-specific Abs derived from the murine system, together with anti-trout Ig Abs and Percoll gradient separation, we analyzed B cells from trout kidney sections and compared them to those from spleen and blood. For this study, immune cells were separated by Percoll gradients, and the resulting subpopulations were defined based on expression of B cell-specific transcription factors Pax-5 and B lymphocyte-induced maturation protein-1, as well as proliferative and Ig-secreting properties. Comparison of kidney, blood, and spleen B cell subsets suggest that 1) the anterior kidney contains mostly proliferating B cell precursors and plasma cells; 2) posterior kidney houses significant populations of (partially) activated B cells and plasmablasts; and 3) trout blood contains resting, non-Ig-secreting cells and lacks plasma cells. After LPS induction of resting B cells in vitro, the kidney and spleen have a high capacity for the generation of plasma cells, whereas the blood has virtually none. Our results indicate that trout B cell subsets are profoundly different among blood, anterior kidney, posterior kidney, and spleen. We hypothesize that developing B cells mature in the anterior side of the kidney and then migrate to sites of activation, either the spleen or the posterior kidney. Lastly, our data support the notion that the trout kidney is a complex, multifunctional immune organ with the potential to support both hemopoiesis as well as humoral immune activation.

show abstract

Ontogeny of B and T cells in sea bass (Dicentrarchus labrax, L.)

Cited by 61 publications

References 34 publications

Ontogeny of IgM-producing cells in the mandarin fish Siniperca chuatsi identified by in situ hybridisation

Ontogeny of IgM-producing cells in the mandarin fish Siniperca chuatsi identified by in situ hybridisation

Ontogeny of the immune system of fish

B Cell Heterogeneity in the Teleost Kidney: Evidence for a Maturation Gradient from Anterior to Posterior Kidney

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