Oocyte quality in women with infertility associated endometriosis

Оразов, М Р; Radzinsky, Victor Yevseyevich; Ivanov, I; Хамошина, М.Б.; Shustova, Victoriya Borisovna

doi:10.1080/09513590.2019.1632088

Cited by 35 publications

(22 citation statements)

References 11 publications

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“…This review showed that there a lower number of MII oocytes retrieved from women with endometriomas which is an agreements with other studies [ 23 , 35 ]. However, some studies showed no negative effect of an endometrioma on MII oocytes [ 34 , 58 ].…”

Section: Discussionsupporting

confidence: 91%

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The impact of endometrioma on in vitro fertilisation/intra-cytoplasmic injection IVF/ICSI reproductive outcomes: a systematic review and meta-analysis

Alshehre

Narice

Fenwick

et al. 2020

Arch Gynecol Obstet

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Background Assisted reproductive technologies (ART) such as in vitro fertilisation (IVF) and intra-cytoplasmic sperm injection (ICSI) are often used to aid fertility in women with endometrioma; however, the implications of endometrioma on ART are unresolved. Objective To determine the effect of endometrioma on reproductive outcomes in women undergoing IVF or ICSI. Methods A systematic review and meta-analysis was conducted to identify articles examining women who had endometrioma and had undergone IVF or ICSI. Electronic searches were performed in PubMed, BIOSIS and MEDLINE up to September 2019. The primary outcome was live birth rate (LBR). Secondary outcomes included clinical pregnancy rate (CPR), implantation rate (IR), number of oocytes retrieved, number of metaphase II (MII) oocytes retrieved, number of embryos and top-quality embryos and the duration of gonadotrophin stimulation and dose. Results Eight studies were included. Where significant heterogeneity between studies was identified, a random-effects model was used. The number of oocytes (weighted means difference; WMD-2.25; 95% CI 3.43 to − 1.06, p = 0.0002) and the number of MII oocytes retrieved (WMD-4.64; 95% CI 5.65 to − 3.63, p < 0.00001) were significantly lower in women with endometrioma versus controls. All other outcomes, including gonadotrophin dose and duration, the total number of embryos, high-quality embryos, CPR, IR and LBR were similar in women with and without endometrioma. Conclusion Even though women with endometriomas had a reduced number of oocytes and MII oocytes retrieved when compared to women without, no other differences in reproductive outcomes were identified. This implies that IVF/ICSI is a beneficial ART approach for women with endometrioma.

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Section: Discussionsupporting

confidence: 91%

“…All eight studies [ 19 – 21 , 30 – 32 , 34 , 35 ] reported on the number of oocytes retrieved, which allowed quantitative pooled analysis. A significantly lower number of oocytes was retrieved from the endometrioma group relative to the control group (WMD-2.25; 95% CI 3.43 to − 1.06, p = 0.0002).…”

Section: Resultsmentioning

confidence: 99%

The impact of endometrioma on in vitro fertilisation/intra-cytoplasmic injection IVF/ICSI reproductive outcomes: a systematic review and meta-analysis

Alshehre

Narice

Fenwick

et al. 2020

Arch Gynecol Obstet

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“…Cluster 3 genes were enriched into the terms meiosis I and mitotic DNA replication. Endometriosis has a negative effect on oocyte quality and ovarian reserve, which may be the underlying cause of endometriosis-associated infertility (Orazov et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Analysis of astaxanthin molecular targets based on network pharmacological strategies

Lin

Tan

et al. 2021

J Food Biochem

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In order to further explore the potential pharmacological activity of astaxanthin (AST), network pharmacological approaches were employed in this work to systematically investigate its affinity targets, perturbed signaling pathways, and related disease applications. First, potential targets were captured based on AST chemical structure information. Enrichment analysis was then performed using bioinformatics tools to predict the biological processes and diseases in which AST targets are involved. The results suggest that AST is involved in steroid hormone metabolism, and the regulation of glucocorticoids may be one of the potential mechanisms of its known therapeutic effects on depression and insulin resistance. Molecular docking experiments confirmed that AST can form stable binding to several key nodes (SRD5A2, STS, AKR1C2, HSD11B1, and CYP17A1) in steroid hormone biosynthesis.More importantly, the molecular targets of AST were the most significantly associated with endometriosis. Functionally, grouped analysis of key therapeutic nodes was carried out by establishing the interaction network between drug targets and disease targets. While exerting inflammatory effects, the regulation of estrogen and other semiochemicals by targeting steroid metabolism may be the biological basis for the potential treatment of endometriosis with AST. This work provides a theoretical basis for further exploring the pharmacological mechanisms of AST and development of new therapeutic applications. Practical applicationsIn this study, systematic pharmacological methods were used to identify the potential therapeutic effects and associated mechanisms of astaxanthin, providing a bioinformatics basis for further exploration of astaxanthin's new pharmacological properties in foods.

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“…This original study was approved by the Institutional Review Board of the School of Medicine, Shandong University (No. 2019- [1][2][3][4][5][6][7][8][9][10][11][12][13][14]. In all, the records of 513 patients were collected, of whom 240 had achieved a live birth.…”

Section: Study Design and Populationmentioning

confidence: 99%

“…Some evidence indicates that ovarian surgery simply decreases the amount of viable ovarian tissue (6,7). Moreover, surgical manipulation might reduce the ovarian reserve, impede ovarian response, and possibly decrease the ART success rate (8)(9)(10). A systematic meta review of 13 studies has shown that surgical and expectant management of endometriomas prior to IVF yielded similar clinical pregnancy and live birth rates, antral follicle count (AFC), mature oocyte numbers, and miscarriage rates (11).…”

Section: Introductionmentioning

confidence: 99%

Factors Influencing the Live Birth Rate Following Fresh Embryo Transfer Cycles in Infertile Women After Endometrioma Cystectomy

et al. 2021

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Background: Reproductive outcomes after fresh in vitro fertilization/intracytoplasmic sperm injection–embryo transfer (IVF/ICSI–ET) cycles are diverse in infertile women with a history of ovarian cystectomy for endometriomas. We aimed to develop a logistic regression model based on patients' characteristics including number of embryos transferred and stimulation protocols to predict the live birth rate in fresh IVF/ICSI–ET cycles for such patients.Methods: We recruited 513 infertile women with a history of ovarian cystectomy for endometriomas who underwent their first fresh ET with different stimulation protocols following IVF/ICSI cycles in our unit from January 2014 to December 2018. One or two embryo are implanted. Clinical and laboratory parameters potentially affecting the live birth rate following fresh ET cycles were analyzed. Univariable and multivariable analyses were performed to assess the relationship between predictive factors and live birth rate.Results: The overall live birth rate was 240/513 (46.8%). Multivariable modified Poisson regression models showed that two factors were significantly lowers the probability of live birth: female age ≥ 5 years (aOR 0.603; 95% CI 0.389–0.933; P = 0.023); BMI range 21–24.99 kg/m2 compared with BMI <21 kg/m2 (aOR 0.572; 95% CI 0.372–0.881, P = 0.011). And two factors significantly increased the probability of live birth: AFC >7 (aOR 1.591; 95% CI 1.075–2.353; P = 0.020); two embryos transferred (aOR 1.607; 95% CI 1.089–2.372; P = 0.017).Conclusions: For these infertile women who had undergone ovarian cystectomy for endometriosis, female age <35 years, AFC > 7, and two embryos transferred might achieve better clinical fresh IVF/ICSI–ET outcomes. BMI <21 kg/m2 or ≥25 kg/m2 might also have positive effects on the live birth rate, but different ovarian stimulation protocols had no significant effects. However, a larger sample size may be needed for further study.

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Oocyte quality in women with infertility associated endometriosis

Cited by 35 publications

References 11 publications

The impact of endometrioma on in vitro fertilisation/intra-cytoplasmic injection IVF/ICSI reproductive outcomes: a systematic review and meta-analysis

The impact of endometrioma on in vitro fertilisation/intra-cytoplasmic injection IVF/ICSI reproductive outcomes: a systematic review and meta-analysis

Analysis of astaxanthin molecular targets based on network pharmacological strategies

Factors Influencing the Live Birth Rate Following Fresh Embryo Transfer Cycles in Infertile Women After Endometrioma Cystectomy

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