Diagnosis systems for laser processing are being integrated into industry. However, their readiness level is still questionable under the prism of the Industry’s 4.0 design principles for interoperability and intuitive technical assistance. This paper presents a novel multifunctional, web-based, real-time quality diagnosis platform, in the context of a laser welding application, fused with decision support, data visualization, storing, and post-processing functionalities. The platform’s core considers a quality assessment module, based upon a three-stage method which utilizes feature extraction and machine learning techniques for weld defect detection and quality prediction. A multisensorial configuration streams image data from the weld pool to the module in which a statistical and geometrical method is applied for selecting the input features for the classification model. A Hidden Markov Model is then used to fuse this information with earlier results for a decision to be made on the basis of maximum likelihood. The outcome is fed through web services in a tailored User Interface. The platform’s operation has been validated with real data.