2011
DOI: 10.1590/s0102-09352011000600009
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Ophthalmic and anesthetic evaluation of topical 1% tetracaine and 0.5% proparacaine in dogs

Abstract: The aim of this study was to establish the action of 1% tetracaine eye drops in combination with 0.1% phenylephrine in two different posologies and their effects on the eye compared to the 0.5% proparacaine drops in dogs. 22 animals were divided into two groups: TG (11 animals), received 1% tetracaine associated with 0.1% phenylephrine eye drops, one drop instilled in the left eye and two drops, with one-minute interval between each, instilled in the right eye; PG (11 animals) received 0.5% proparacaine eye dr… Show more

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Cited by 8 publications
(5 citation statements)
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“…Its corneal anesthetic effects have been established in horses, dogs,, and cats . Tetracaine eye drops are available in form of a 0.5% and 1.0% aqueous solutions or a 0.5% viscous formulation . The depth and duration of their pharmacological effects on corneal sensitivity have been assessed in clinically normal dogs and horses .…”
Section: Introductionmentioning
confidence: 99%
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“…Its corneal anesthetic effects have been established in horses, dogs,, and cats . Tetracaine eye drops are available in form of a 0.5% and 1.0% aqueous solutions or a 0.5% viscous formulation . The depth and duration of their pharmacological effects on corneal sensitivity have been assessed in clinically normal dogs and horses .…”
Section: Introductionmentioning
confidence: 99%
“…Tetracaine eye drops are available in form of a 0.5% and 1.0% aqueous solutions or a 0.5% viscous formulation . The depth and duration of their pharmacological effects on corneal sensitivity have been assessed in clinically normal dogs and horses . Oxybuprocaine (benoxinate) is a para‐aminobenzoic acid ester developed in the early 50s to serve as a topical anesthetic in human, and which analgesic effects on human cornea have been known since 1955 .…”
Section: Introductionmentioning
confidence: 99%
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“…6 Parchen et al reported a significant decrease in IOP in dogs 30 mins and 50 mins after tetracaine and proparacaine administration, respectively. 8 In a study by Boillot et al, 5 IOP decreased 1 min after tetracaine administration in the treated eye in dogs. 5 All these studies in dogs showed significant alterations in IOP at different time points.…”
Section: Discussionmentioning
confidence: 96%
“…In contrast, tetracaine had a peak effect at 1 min post application, with palpebral opening returning to baseline values by 10 min. Previous studies comparing these three anesthetics have used ophthalmically normal animals and assessed corneal anesthesia using mechanically-evoked reflexes [39][40][41][42] . In these studies, tetracaine and oxybruprocaine had a similar duration of action, and tetracaine had a slightly longer duration of action when compared to proparacaine.…”
Section: Discussionmentioning
confidence: 99%