Opioid-induced hyperalgesia in a mice model of orthopaedic pain: preventive effect of ketamine

Abstract

Background. The aim of this study was to assess the preventative effect of ketamine on the exaggerated postoperative pain observed in sufentanil-treated mice and its ability to improve the analgesic effectiveness of morphine during the postoperative period in an orthopaedic model of pain.

Phosphorylation of the GluN1 subunit in dorsal horn neurons by remifentanil: a mechanism for opioid-induced hyperalgesia

“…Although ketamine acts on a variety of receptors, its analgesic effects stem mainly from its antagonism of NMDARs and prevention of central sensitization (Hirota and Lambert, 1996). One study has demonstrated the efficacy of NMDAR antagonists for preventing OIH (Minville et al, 2010). Furthermore, a number of investigations found that clinical doses of naloxone antagonize opioid effects, whereas ultra-low doses enhance the antinociceptive effects of morphine (Tsai et al, 2008;Yang et al, 2011).…”

Medication-overuse headache and opioid-induced hyperalgesia: A review of mechanisms, a neuroimmune hypothesis and a novel approach to treatment

“…[73][74][75] Alternatively, it has been speculated that biologically active glucuronide metabolites may play a role in morphine-induced hyperalgesia. 76,77 The metabolite morphine-3-glucuronide, which is known to possess very little affinity for any of the opioid receptor subtypes, 78,79 is able to stimulate potent neuro-excitatory effects on behaviour when administered to rodents, 80, 81 yet this hypothesis does not explain opioid-induced hyperalgesia following administration of opioids which do not form glucuronide metabolites such as fentanyl.…”

Intravenous macrolide use: a reminder of the dangers of rapid infusion rates

“…Patient tolerability to IV clarithromycin is poor [2][3][4]; indeed one study group was forced to discontinue IV infusions in 50% of its participants due to drug-induced severe pain [2]. Most studies investigating IV macrolide tolerance and subsequent irritation have been shown in patients treated for lower respiratory tract infections [3,4].…”

“…Additional benefits include improved staff scheduling, medical decision-making support, and quality improvement monitoring [2]. Advances in the sophistication of computer workstations and network components, and an industry trend towards electronic medical record (EMR) implementation, have driven the development of AIMS that interfaces with the hospital's software system.…”

“…Advances in the sophistication of computer workstations and network components, and an industry trend towards electronic medical record (EMR) implementation, have driven the development of AIMS that interfaces with the hospital's software system. Despite these advances, fewer than 90% of medical centers have adopted an AIMS due to the uncertainty of various costs [2].…”