Opioid receptors modulate recovery from consummatory successive negative contrast

Pellegrini, Santiago; Wood, Michael D.; Daniel, Alan M.; Papini, Mauricio R.

doi:10.1016/j.bbr.2005.06.035

Cited by 55 publications

(63 citation statements)

References 28 publications

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“…A potential route of exploration involves treatments known to enhance these effects in mammals. For example, opioid receptor blockage with naloxone (a nonselective opioid receptor antagonist) and naltrindole (a delta-opioid receptor antagonist) has been shown to enhance cSNC in rats [34], [35]. Opioid receptors have been described in amphibians and are known to be homologous to those found in mammals [36], [37].…”

Section: Discussionmentioning

confidence: 99%

Incentive or Habit Learning in Amphibians?

et al. 2011

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Toads (Rhinella arenarum) received training with a novel incentive procedure involving access to solutions of different NaCl concentrations. In Experiment 1, instrumental behavior and weight variation data confirmed that such solutions yield incentive values ranging from appetitive (deionized water, DW, leading to weight gain), to neutral (300 mM slightly hypertonic solution, leading to no net weight gain or loss), and aversive (800 mM highly hypertonic solution leading to weight loss). In Experiment 2, a downshift from DW to a 300 mM solution or an upshift from a 300 mM solution to DW led to a gradual adjustment in instrumental behavior. In Experiment 3, extinction was similar after acquisition with access to only DW or with a random mixture of DW and 300 mM. In Experiment 4, a downshift from DW to 225, 212, or 200 mM solutions led again to gradual adjustments. These findings add to a growing body of comparative evidence suggesting that amphibians adjust to incentive shifts on the basis of habit formation and reorganization.

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Section: Discussionmentioning

confidence: 99%

Incentive or Habit Learning in Amphibians?

et al. 2011

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“…For example, the nonselective opioid-receptor agonist morphine reduces the cSNC effect (Rowan and Flaherty, 1987), whereas the nonselective antagonist naloxone enhances the cSNC effect (Daniel et al, 2009;Pellegrini et al, 2005). Both of these effects are observed whether the drug is administered before the first or the second downshift session.…”

Section: Role Of Opioid and Cannabinoid Receptorsmentioning

confidence: 93%

“…Interestingly, selective opioid-receptor compounds can have effects on either the initial reaction to the downshift or after the animal has had some experience with the downshifted reward. For example, the delta opioid-receptor agonist DPDPE [d-Penicillamine(2,5)-enkephalin] and antagonist naltrindole reduced and enhanced the cSNC effect, respectively, when administered before the first downshift session, but had no effects when administered before the second downshift session (Pellegrini et al, 2005;Wood et al, 2005). Conversely, the kappa opioid-receptor agonist U50,488H modulates the cSNC effect when administered before the second downshift session, but has no effects when administered before the first downshift session (Wood et al, 2008).…”

Section: Role Of Opioid and Cannabinoid Receptorsmentioning

confidence: 98%

“…But the new terminology must be justifiable. The key finding that led to suggest the idea of psychological pain in animal research was the discovery that endogenous opioids, known mainly for their ability to reduce physical pain (e.g., Simons et al, 2014), are normally released during an episode of incentive loss, in the absence of any actual or potential tissue damage (Pellegrini et al, 2005). Cannabinoid receptors are also involved in the regulation of physical pain (Anand et al, 2009;Pertwee, 2000) and, therefore, are expected to influence psychological pain, as the review below will show.…”

Section: Why "Psychological Pain"?mentioning

confidence: 99%

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Behavioral neuroscience of psychological pain

Papini

Fuchs

Torres

2015

Neuroscience & Biobehavioral Reviews

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“…For example, Pellegrini et al [52] reported that the exploratory behavior of animals that recovered slowly from the downshift was more disrupted by the nonselective opioid-receptor antagonist naloxone than the behavior of animals that recovered relatively faster. Moreover, rats artificially selected for high recovery rates exhibited enhanced opioid receptor efficiency during reward downshift, attenuated emotional reactivity to partial reinforcement, and increased ultrasound vocalization to infant separation relative to low and random lines [40].…”

Section: Discussionmentioning

confidence: 99%

Identifying profiles of recovery from reward devaluation in rats

Papini

Galatzer‐Levy

Papini

2014

Behavioural Brain Research

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In humans and other mammals, the unexpected loss of a resource can lead to emotional conflict. Consummatory successive negative contrast (cSNC) is a laboratory model of reward devaluation meant to capture that conflict. In this paradigm, animals are exposed to a sharp reduction in the sucrose concentration of a solution after several days of access. This downshift in sucrose content leads to behavioral responses such as the suppression of consumption and physiologic responses including elevation of corticosterone levels. However, response heterogeneity in cSNC has yet to be explored and may be relevant for increasing the validity of this model, as humans demonstrate clinically meaningful heterogeneity in response to resource loss. The current analysis applied latent growth mixture modeling to test for and characterize heterogeneity in recovery from cSNC among rats (N = 262). Although most animals exhibited recovery of consummatory behavior after a sharp drop in consumption in the first postshift trial (Recovery class; 83%), two additional classes were identified including animals that did not change their consumption levels after downshift (No Contrast class; 6%), and animals that exhibited an initial response similar to that of the Recovery class did not recover to preshift consumption levels (No Recovery class; 11%). These results indicate heterogeneity in recovery from reward loss among rats, which may increase the translatability of this animal model to understand diverse responses to loss among humans.

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Opioid receptors modulate recovery from consummatory successive negative contrast

Cited by 55 publications

References 28 publications

Incentive or Habit Learning in Amphibians?

Incentive or Habit Learning in Amphibians?

Behavioral neuroscience of psychological pain

Identifying profiles of recovery from reward devaluation in rats

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