Opsoclonus in three dimensions: oculographic, neuropathologic and modelling correlates

Wong, Agnes M. F.; Musallam, Sam; Tomlinson, R. D.; Shannon, Patrick; Sharpe, James

doi:10.1016/s0022-510x(01)00564-0

Cited by 127 publications

(89 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The numerous activated lymphocytes and plasma cells in CSF of these patients corroborate the finding of intrathecal Ig synthesis. These results correspond to neuropathological evidence of perivascular lymphocytic cuffing [1,10,15,21,46] including B-lymphocyte infiltrates [47] in paraneoplastic OMS patients. Nevertheless, perivascular lymphocytic aggregates in the brainstem, cerebellum and other parts of the brain are sometimes also seen in idiopathic or parainfectious cases [10,21,44].…”

Section: Discussionsupporting

confidence: 87%

See 1 more Smart Citation

Opsoclonus—myoclonus—dysequilibrium syndrome: cytological and immunological dynamics in the serial cerebrospinal fluid in two patients

Bartoš

Piťha

2003

J Neurol

View full text Add to dashboard Cite

A peculiar clinical presentation characterized by the triad of opsoclonus,myoclonus and ataxia, mainly in a form of dysequilibrium, is usually associated with infectious or paraneoplastic processes. Serial cerebrospinal fluid (CSF) analysis in two patients with opsoclonus-myoclonus-dysequilibrium syndrome suggestive of viral encephalitis were performed from disease onset for up to 8 months. A cell count, cytology, total protein and glucose concentrations in CSF, the blood-CSF barrier function, intrathecal synthesis of immunoglobulins (Ig) in class M, G and A expressed as IgM, IgG and IgA indices and oligoclonal IgG bands were monitored. Cellular and humoral alterations in both patients were slight at the onset becoming more pronounced a month later. The kinetics of the CSF changes mirrored the subacute clinical deterioration and subsequent recovery. The delayed response in the CSF measures and the gradual clinical deterioration suggest the development of subacute brain inflammation. A mononuclear pleocytosis, including macrophages and plasma cells, increased within the first month and then normalized during the following weeks. Intrathecally synthesized IgM occurred only transiently after one month of illness, whereas intrathecal IgG production increased during the first month and persisted for at least eight months. An increasing number of oligoclonal IgG bands during the course, indicative of expanding local intrathecal synthesis, was noted. The dynamics of these CSF changes supports the hypothesis that opsoclonus-myoclonus syndrome is a post-infectious immune- mediated condition.

show abstract

Section: Discussionsupporting

confidence: 87%

“…These signs are due to brainstem involvement supported by both histopathological [10,21,39,46,47] and brain MRI findings [2,17].…”

Section: Discussionmentioning

confidence: 94%

Opsoclonus—myoclonus—dysequilibrium syndrome: cytological and immunological dynamics in the serial cerebrospinal fluid in two patients

Bartoš

Piťha

2003

J Neurol

View full text Add to dashboard Cite

show abstract

“…Pathophysiological mechanisms have been suspected of involving the ''pause'' neurons that normally prevent saccade oscillations during fixation by inhibiting Fburst_ neuron firing [18]. Recent studies also suggest the role of the fastigial nucleus in saccadic eye oscillations and in controlling horizontal saccades during adaptation [19,20]. However, in our case, we did not observe any cerebellar lesions on MRI.…”

Section: Discussioncontrasting

confidence: 74%

Unusual ocular motor findings in multiple sclerosis

Seze¹,

Vukusic²,

Viallet-Marcel³

et al. 2006

Journal of the Neurological Sciences

View full text Add to dashboard Cite

“…Although it has been postulated that delayed cerebellar feedback may lead to saccadic oscillations without an intersaccadic interval, 20 experimentally blocking feedback by inactivating parallel fibers, 17 or the fastigial nucleus, 14 causes saccadic dysmetria, not opsoclonus. If our hypothesis is correct, then it might also apply to the onset of smooth-pursuit movements, which is under fastigial control, 5 and might generalize as a mechanism of cerebellar limb ataxia.…”

Section: Fig 1 Summary Of the Disorder Of Saccadic Eye Movements (Amentioning

confidence: 99%

Pathogenesis of clinical signs in recessive ataxia with saccadic intrusions

Swartz¹,

Li²,

Bespalova³

et al. 2003

Annals of Neurology

View full text Add to dashboard Cite

We describe a family of Slovenian descent with progressive ataxia, corticospinal signs, axonal sensorimotor neuropathy, and disruption of visual fixation by saccadic intrusions. Chromosome mapping indicated a mutation on 1p36, and this recessive disorder has been designated spinocerebellar ataxia with saccadic intrusions. Affected patients showed overshooting horizontal saccades, macrosaccadic oscillations, and increased velocity of larger saccades; other eye movements were normal. Slowed conduction in axons that are selectively vulnerable to the molecular defect could explain both the sensorimotor neuropathy and the saccadic disorder, which would be caused by delayed feedback control because of slow conduction in cerebellar parallel fibers.

show abstract

Opsoclonus in three dimensions: oculographic, neuropathologic and modelling correlates

Cited by 127 publications

References 44 publications

Opsoclonus—myoclonus—dysequilibrium syndrome: cytological and immunological dynamics in the serial cerebrospinal fluid in two patients

Opsoclonus—myoclonus—dysequilibrium syndrome: cytological and immunological dynamics in the serial cerebrospinal fluid in two patients

Unusual ocular motor findings in multiple sclerosis

Pathogenesis of clinical signs in recessive ataxia with saccadic intrusions

Contact Info

Product

Resources

About