Optical and structural properties of PMMA/C60 composites with different concentrations of C60 molecules and its possible applications

Stanković, Ivana; Matija, Lidija; Jankov, Mirko; Jeftić, Branislava; Koruga, I.; Koruga, Dj.

doi:10.1007/s10965-020-02203-4

Cited by 4 publications

(2 citation statements)

References 30 publications

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“…For the irradiation of cells, a Bioptron ® 2 device (Bioptron AG, Wollerau, Switzerland) equipped with a nanophotonic fullerene filter was used. This filter, 2 mm thick, was made from polymethyl methacrylate (PMMA) glass with the addition of 0.3% fullerene [35,36]. It allows the production of incoherent, out-of-phase unsynchronized hyperpolarized polychromatic light (HPL) ranging from 400 to 1100 nm.…”

Section: Irradiation Sourcementioning

confidence: 99%

Combined Action of Hyper-Harmonized Hydroxylated Fullerene Water Complex and Hyperpolarized Light Leads to Melanoma Cell Reprogramming In Vitro

et al. 2022

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(1) Background: Their unique structure and electron deficiency have brought fullerenes into the focus of research in many fields, including medicine. The hyper-harmonized hydroxylated fullerene water complex (3HFWC) formulation has solved the limitations of the poor solubility and bioavailability of fullerenes. To achieve better antitumor activity, 3HFWC was combined with short-term irradiation of cells with hyperpolarized light (HPL) generated by the application of a nanophotonic fullerene filter in a Bioptron® device. The benefits of HPL were confirmed in the microcirculation, wound healing and immunological function. (2) Methods: B16, B16-F10 and A375 melanoma cells were exposed to a wide spectrum of 3HFWC doses and to a single short-term HPL irradiation. (3) Results: Apart from the differences in the redox status and level of invasiveness, the effects of the treatments were quite similar. Decreased viability, morphological alteration, signs of melanocytic differentiation and cellular senescence were observed upon the successful internalization of the nanoquantum substance. (4) Conclusions: Overall, 3HFWC/HPL promoted melanoma cell reprogramming toward a normal phenotype.

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Section: Irradiation Sourcementioning

confidence: 99%

Combined Action of Hyper-Harmonized Hydroxylated Fullerene Water Complex and Hyperpolarized Light Leads to Melanoma Cell Reprogramming In Vitro

et al. 2022

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“…This device produces polychromatic, non-coherent linearly polarized light (via a Stoletov glass pile placed at a Brewster angle) with wavelengths 320-3400 nm. The fullerene filter, 2 mm thick, was made from polymethyl methacrylate (PMMA) glass with the addition of 0.3% fullerene (PMMA-C 60 ) [38][39][40][41]. The power density of light passed through the fullerene filter measured from a 5 cm distance was 55-65 mW/cm 2 .…”

Section: Methodsmentioning

confidence: 99%

Fullerene-Filtered Light Spectrum and Fullerenes Modulate Emotional and Pain Processing in Mice

Lazović

Zopf

Hren³

et al. 2021

Symmetry

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The most symmetric molecule, Buckminster fullerene C60, due to its unique properties, has been intensively studied for various medical and technological advances. Minimally invasive and minimally toxic treatments hold great promise for future applications. With this in mind, this research exploited the physical properties of fullerene molecules for potential therapeutic effects. Pristine fullerenes have peak absorbance in the 380–500 nm range, making them an attractive violet-blue light filter. Since spectral quality of light can affect behavior, this research used resting state functional magnetic resonance imaging (rs fMRI) and behavioral testing to directly evaluate the effects of fullerene-filtered light on brain processing and behavior in mice. The same method was used to study if hydroxyl fullerene water complexes (3HFWC), with or without fullerene-filtered light, modulated brain processing. A month-long, daily exposure to fullerene-filtered light led to decreased activation of the brain area involved in emotional processing (amygdala). Water supplemented with 3HFWC resulted in an activation of brain areas involved in pain modulation and processing (periaqueductal gray), and decreased latency to first reaction when tested with a hot plate. The combination of fullerene-filtered light with 3HFWC in drinking water led to restored sensitivity to a hot plate and activation of brain areas involved in cognitive functions (prelimbic, anterior cingulate and retrosplenial cortex). These results uncovered the potential of fullerene-filtered light to impact emotional processing and modulate pain perception, indicating its further use in stress and pain management.

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Dielectric and optical properties of alumina and silica nanoparticles dispersed poly(methyl methacrylate) matrix-based nanocomposites for advanced polymer technologies

2021

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Optical and structural properties of PMMA/C60 composites with different concentrations of C60 molecules and its possible applications

Cited by 4 publications

References 30 publications

Combined Action of Hyper-Harmonized Hydroxylated Fullerene Water Complex and Hyperpolarized Light Leads to Melanoma Cell Reprogramming In Vitro

Combined Action of Hyper-Harmonized Hydroxylated Fullerene Water Complex and Hyperpolarized Light Leads to Melanoma Cell Reprogramming In Vitro

Fullerene-Filtered Light Spectrum and Fullerenes Modulate Emotional and Pain Processing in Mice

Dielectric and optical properties of alumina and silica nanoparticles dispersed poly(methyl methacrylate) matrix-based nanocomposites for advanced polymer technologies

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