Optical coherence tomography: From technology to applications in ophthalmology

Everett, Matthew J.; Magazzeni, Stéphanie; Schmoll, Tilman; Kempe, M.

doi:10.1002/tbio.202000012

Cited by 37 publications

(20 citation statements)

References 71 publications

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“…This custom-built spectral-domain OCT system has a center wavelength (λ) of 1325 nm, bandwidth of 100 nm, and an A-line (sampling) rate of 28.3 kHz. OCT has been commonly used to provide highresolution cross-sectional images of biological tissues, such as skin [26] or retina [27]. OCT can also measure dynamic motion and displacement of moving objects in a non-contact manner, making it a very useful technique to measure the small, dynamic motion of µPEMs under AC excitation.…”

Section: Device Characterization For Dynamic Actuationmentioning

confidence: 99%

Fabrication and development of novel micromachined parylene-based electroactive membranes with embedded microfluidic architectures

Uscanga

Pierce

Zahn

2023

J. Micromech. Microeng.

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This work describes the design, fabrication, modeling, and testing of monolithic micromachined parylene-based electroactive membranes (μPEMs) with embedded microfluidic channels. The design and modeling employed analytical plate theory to determine the optimal membrane dimensions and structural shapes for various microsystem designs. The μPEMs were fabricated using a combination of surface and bulk micromachining techniques incorporating Parylene C as a biocompatible polymeric structural material combined with patterned electrodes for actuation. Experimental actuation of the electroactive membranes demonstrated reliability with minimal voltage shifts, and theoretical pull-in voltages closely matching experimental results. Different structural parameters of the μPEMs were also tested, such as varying the overall membrane thickness/structural rigidity and actuation chamber depth. Dynamic actuation of the membrane, including, the deflection and system response to various actuation frequencies, was observed and quantified via optical coherence tomography (OCT) techniques. Microfluidic architectures were monolithically integrated with the membrane actuator and successfully perfused, with no signs of leakage. This compact microsystem has potential applications in microfluidics and Lab/System-On-A-Chip devices, for use in micromixers, particle manipulators, and applying strain to adherent cells cultured on top of the membrane.

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Section: Device Characterization For Dynamic Actuationmentioning

confidence: 99%

Fabrication and development of novel micromachined parylene-based electroactive membranes with embedded microfluidic architectures

Uscanga

Pierce

Zahn

2023

J. Micromech. Microeng.

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“…To address this gap in imaging capability, wide-field OCT technology (WF-OCT) with FOV around 40–55 degrees and ultrawide-field OCT (UWF-OCT) with FOV up to 200 degrees in a volumetric scan were developed ( Figure 6 ) [ 28 , 86 ]. SS-OCT with a higher imaging speed (100,000 A scans/s) also has an advantage of enhanced depth scan range which is essential to image the curved contour of the peripheral retina [ 87 ]. Early WF-OCTs were based upon an InGaAs diode array that enabled a higher readout rate and a FOV of 38 degrees [ 27 ].…”

Section: Wide-field and Ultrawide-field Oct (Wf-oct And Uwf-oct)mentioning

confidence: 99%

Advances in Optical Coherence Tomography Imaging Technology and Techniques for Choroidal and Retinal Disorders

Ong

Zarnegar

Corradetti

et al. 2022

JCM

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Optical coherence tomography (OCT) imaging has played a pivotal role in the field of retina. This light-based, non-invasive imaging modality provides high-quality, cross-sectional analysis of the retina and has revolutionized the diagnosis and management of retinal and choroidal diseases. Since its introduction in the early 1990s, OCT technology has continued to advance to provide quicker acquisition times and higher resolution. In this manuscript, we discuss some of the most recent advances in OCT technology and techniques for choroidal and retinal diseases. The emerging innovations discussed include wide-field OCT, adaptive optics OCT, polarization sensitive OCT, full-field OCT, hand-held OCT, intraoperative OCT, at-home OCT, and more. The applications of these rising OCT systems and techniques will allow for a closer monitoring of chorioretinal diseases and treatment response, more robust analysis in basic science research, and further insights into surgical management. In addition, these innovations to optimize visualization of the choroid and retina offer a promising future for advancing our understanding of the pathophysiology of chorioretinal diseases.

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“…Of course, OCT is more practical and precise and has a better spectrum of indications for obtaining histometric data than routine histology examinations. 11 A recent study demonstrated the importance of histometric data from the cornea in patients before cataract surgery. 12 On the other hand, the width measurement of keratinized gingiva, supracrestal gingival tissue, sulcus depth, and biological width has been demonstrated.…”

Section: Editorialmentioning

confidence: 99%