Optical Coherence Tomography in Neuromyelitis Optica spectrum disorder and Multiple Sclerosis: A population-based study

Ashtari, Fereshteh; Ataei, Akram; Kafieh, Raheleh; Khodabandeh, Zahra; Barzegar, Mahdi; Raei, Marzieh; Dehghani, Alireza; Mansurian, Marjan

doi:10.1016/j.msard.2020.102625

Cited by 16 publications

(12 citation statements)

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“…The lack of significance between NMOSD and RRMS+ON might be related to the high number of ON attacks observed in our RRMS+ON group in addition to the higher disease duration in the MS cohort that contribute to subclinical loss of retinal layer thickness. The significant greater thickness loss in all disease groups compared with HC was expected and in line with previous reports [ 28 , 31 , 32 ].…”

Section: Discussionsupporting

confidence: 92%

Optical Coherence Tomography in Chronic Relapsing Inflammatory Optic Neuropathy, Neuromyelitis Optica and Multiple Sclerosis: A Comparative Study

et al. 2022

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Purpose: To examine the optical coherence tomography (OCT) features of the retina in patients with chronic relapsing inflammatory optic neuropathy (CRION) and compare them with those of neuromyelitis optica spectrum disorder (NMOSD), relapsing-remitting multiple sclerosis (RRMS) with and without optic neuritis (ON), and healthy controls (HC). Methods: In this retrospective cross-sectional study, we used spectral domain OCT to evaluate the retinal structure of 14 participants with CRION, 22 with NMOSD, 40 with RRMS with unilateral ON, and 20 HC. The peripapillary retinal nerve fiber layer (pRNFL), total macular volume (TMV), and papillomacular bundle (PMB) were measured, and intra-retinal segmentation was performed to obtain the retinal nerve fiber (RNFL), ganglion cell (GCL), inner plexiform (IPL), inner nuclear (INL), outer plexiform (OPL) and outer nuclear (ONL) layer volumes. Results: The global pRNFL [39.33(±1.8) µm] and all its quadrants are significantly thinner in CRION compared with all other groups (p < 0.05). CRION patients have decreased volumes of TMV, RNFL, GCL, and IPL compared with all other groups (p < 0.05). Conclusion: Severe thinning in pRNFL and thinning in intra-retinal segments of IPL, GCL, RNFL, and TMV could be helpful in differentiating CRION from NMOSD and RRMS.

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Section: Discussionsupporting

confidence: 92%

Optical Coherence Tomography in Chronic Relapsing Inflammatory Optic Neuropathy, Neuromyelitis Optica and Multiple Sclerosis: A Comparative Study

et al. 2022

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“…A close correlation of GC-IPL thickness with both macular volume and NFL thickness has been demonstrated, all three reduced compared with the healthy control group. Macular metrics changes between MS patients with or without prior optic neuritis are controversial in different studies [ 69 , 70 ]. Another layer under investigation is the inner nuclear layer (INL): some studies have shown that it is not affected by atrophy in MS, but rather by thickening, which is a possible sign of inflammation activity and response to treatment [ 65 ].…”

Section: Introductionmentioning

confidence: 99%

“…It has been shown that the average thickness of pNFL is significantly reduced in NMOSD compared to healthy controls, even in patients not affected by optic neuritis (ON) [ 83 ]. Moreover, this index is also decreased even when related to MS patients and this discrepancy is higher in eyes with history of ON [ 70 , 84 ]. This would appear to be due to greater ON-dependent axonal damage and a higher frequency of these attacks in NMOSD; this could be a marker to distinguish MS from the latter [ 85 ], but further studies will be required to validate this theory.…”

Section: Introductionmentioning

confidence: 99%

Optical coherence tomography as retinal imaging biomarker of neuroinflammation/neurodegeneration in systemic disorders in adults and children

Vujosevic

Parra

Hartnett

et al. 2022

Eye

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The retina and the optic nerve are considered extensions of the central nervous system (CNS) and thus can serve as the window for evaluation of CNS disorders. Spectral domain optical coherence tomography (OCT) allows for detailed evaluation of the retina and the optic nerve. OCT can non-invasively document changes in single retina layer thickness and structure due to neuronal and retinal glial cells (RGC) modifications in systemic and local inflammatory and neurodegenerative diseases. These can include evaluation of retinal nerve fibre layer and ganglion cell complex, hyper-reflective retinal spots (HRS, sign of activated microglial cells in the retina), subfoveal neuroretinal detachment, disorganization of the inner retinal layers (DRIL), thickness and integrity of the outer retinal layers and choroidal thickness. This review paper will report the most recent data on the use of OCT as a non invasive imaging biomarker for evaluation of the most common systemic neuroinflammatory and neurodegenerative/neurocognitive disorders in the adults and in paediatric population. In the adult population the main focus will be on diabetes mellitus, multiple sclerosis, optic neuromyelitis, neuromyelitis optica spectrum disorders, longitudinal extensive transverse myelitis, Alzheimer and Parkinson diseases, Amyotrophic lateral sclerosis, Huntington’s disease and schizophrenia. In the paediatric population, demyelinating diseases, lysosomal storage diseases, Nieman Pick type C disease, hypoxic ischaemic encephalopathy, human immunodeficiency virus, leukodystrophies spinocerebellar ataxia will be addressed.

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“…For instance, the visual outcome after NMOSD ON events is less favorable compared to MS and MOGAD-related ON [4][5][6] . This is supported by greater thinning of RNFL (retinal nerve fiber layer) and GCL (ganglion cell layer) in NMOSD cases compared to typical ON 7 . However, MOGAD carries a propensity towards more frequent ON recurrence, and repeated episodes of ON in MOGAD patients often lead to comparable to NMOSD thinning in the OCT indices 8 .…”

mentioning

confidence: 80%

Chronic relapsing inflammatory optic neuropathy (CRION)

Chwalisz

2022

Arq. Neuro-Psiquiatr.

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Optical Coherence Tomography in Neuromyelitis Optica spectrum disorder and Multiple Sclerosis: A population-based study

Cited by 16 publications

References 50 publications

Optical Coherence Tomography in Chronic Relapsing Inflammatory Optic Neuropathy, Neuromyelitis Optica and Multiple Sclerosis: A Comparative Study

Optical Coherence Tomography in Chronic Relapsing Inflammatory Optic Neuropathy, Neuromyelitis Optica and Multiple Sclerosis: A Comparative Study

Optical coherence tomography as retinal imaging biomarker of neuroinflammation/neurodegeneration in systemic disorders in adults and children

Chronic relapsing inflammatory optic neuropathy (CRION)

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