Optical detection of glucose concentration in samples with scattering particles

Abstract

An optical-based method is proposed for measuring the glucose concentration of samples containing scattering particles. In the proposed approach, a Stokes-Mueller reflection-based polarimetry technique is used to solve the Mueller matrices of a turbid glucose sample with circular birefringence and depolarization properties given six incident lights with different polarization states. Using an error function defined as the difference between the simulated output Stokes vectors and the experimental ones, a genetic algorithm is used to inversely derive the optical rotation and depolarization parameters of the experimental sample corresponding to the glucose concentration and scattering depolarization effect, respectively. The validity of the proposed method is demonstrated using glucose samples containing 0.02 ml and 0.04 ml lipofundin, respectively.

Review of Noninvasive Continuous Glucose Monitoring in Diabetics

“…This property causes glucose to scatter light differently than other biologics, thus can be exploited for glucose detection. 76 Additionally, glucose has a specific absorption band in the near-infrared (NIR) spectrum, that can be used to quantify its concentration via spectroscopic techniques such as diffuse reflectance spectroscopy and Raman spectroscopy. 77 The spectroscopic method for detecting glucose concentration in liquid came into being based on the absorption, refraction, and emission of glucose molecules to light.…”

Broadband Mueller ellipsometer as an all-in-one tool for spectral and temporal analysis of mutarotation kinetics

“…As a rule of thumb, the ellipsometric community has adopted the glucose molecule as a universal representation of a chiral object within the landscape of chemistry. Its clinical implications have attracted attention exploiting MMSE versatility by sensing glucose 19 in media simulating scattering events, 20–22 body-fluid environments, 23 or even phantom tissues 24 and actual human tissues. 25 Moreover, fast and precise response makes MMSE widely popular as an in situ control 26,27 capable of real-time tracking of dynamic processes.…”

“…Its clinical implications have attracted attention exploiting MMSE versatility by sensing glucose 19 in a IT4Innovations, National Supercomputing Center, VSB -Technical University of Ostrava, 17. listopadu 2172/15, 708 00 Ostrava-Poruba, Czech Republic. E-mail: daniel.vala@vsb.cz; kamil.postava@vsb.cz b Faculty of Materials Science and Technology, VSB -Technical University of Ostrava, 17. listopadu 2172/15, 708 00 Ostrava-Poruba, Czech Republic media simulating scattering events, [20][21][22] body-uid environments, 23 or even phantom tissues 24 and actual human tissues. 25 Moreover, fast and precise response makes MMSE widely popular as an in situ control 26,27 capable of real-time tracking of dynamic processes.…”

Optical monitoring of the plant growth status using polarimetry

“…Many parameters can be obtained from polarimetry, including the polarization azimuth angle and ellipticity. However, most previous research has been limited to using only depolarization information for monitoring the state of plants 6 , 8 , 12 , 13 . Thus, an exact correlation between the state of plants and the polarization state of light has not yet been revealed and remains an open issue.…”