Optical fiber array based simultaneous parallel monitoring of resonant cantilever sensors in liquid

Mostafazadeh, Alí; Yaralioglu, G.G.; Ürey, Hakan

doi:10.1016/j.sna.2016.03.004

Cited by 7 publications

(5 citation statements)

References 25 publications

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“…In addition to the above mentioned optical read-out methods, optical lever method with pickup fibers can also be used 15 . Fig 2 shows the general principle of the system.…”

Section: Mems Based Sensormentioning

confidence: 99%

Disposable cartridge biosensor platform for portable diagnostics

et al. 2017

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We developed two types of cantilever-based biosensors for portable diagnostics applications. One sensor is based on MEMS cantilever chip mounted in a microfluidic channel and the other sensor is based on a movable optical fiber placed across a microfluidic channel. Both types of sensors were aimed at direct mechanical measurement of coagulation time in a disposable cartridge using plasma or whole blood samples. There are several similarities and also some important differences between the MEMS based and the optical fiber based solutions. The aim of this paper is to provide a comparison between the two solutions and the results. For both types of sensors, actuation of the cantilever or the moving fiber is achieved using an electro coil and the readout is optical. Since both the actuation and sensing are remote, no electrical connections are required for the cartridge. Therefore it is possible to build low cost disposable cartridges. The reader unit for the cartridge contains light sources, photodetectors, the electro coil, a heater, analog electronics, and a microprocessor. The reader unit has different optical interfaces for the cartridges that have MEMS cantilevers and moving fibers. MEMS based platform has better sensitivity but optomechanical alignment is a challenge and measurements with whole blood were not possible due to high scattering of light by the red blood cells. Fiber sensor based platform has relaxed optomechanical tolerances, ease of manufacturing, and it allows measurements in whole blood. Both sensors were tested using control plasma samples for activated-Partial-Thromboplastin-Time (aPTT) measurements. Control plasma test results matched with the manufacturer's datasheet. Optical fiber based system was tested for aPTT tests with human whole blood samples and the proposed platform provided repeatable test results making the system method of choice for portable diagnostics.

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“…In addition to the above mentioned optical read-out methods, optical lever method with pickup fibers can also be used 15 . Fig 2 shows the general principle of the system.…”

Section: Mems Based Sensormentioning

confidence: 99%

Disposable cartridge biosensor platform for portable diagnostics

et al. 2017

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“…Due to its sensitive detection capabilities, LIAs have been widely used in various applications [26]- [30], and miniaturized into portable systems [31]- [33]. Additionally, LIA systems are used in ultrafast optics [34]- [37] and terahertz spectroscopy [38]- [41] photonic systems.…”

Section: Introductionmentioning

confidence: 99%

Lock-in Amplifier Dairy Sensor for Detection of Ciprofloxacin

et al. 2023

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This work introduces a sensor for dairy antibiotic detection of ciprofloxacin in milk. We provide an important tool for antibiotic detection in milk and the main contributions of this work are as follows. We introduce a technique based on florescence spectroscopy and lock-in amplification for sensing ciprofloxacin in milk that is capable of detection below the regulatory limit. We compare the system against one without the integrated lock-in amplification, as in traditional fluorescence sensors. We provide microchip capillary electrophoresis results and place our work in context for future integration with microchip capillary electrophoresis.

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“…In addition to electrical multiplexers, optical multiplexers for switching optical signals have been recently reported 7 . Techniques for discriminating multiple signals using light have also been reported 8 , 9 . This technique enables switching of multiple signals, even at nanoscale sizes, and is suitable for narrow spaces because of the fiber array.…”

Section: Introductionmentioning

confidence: 99%

Liquid metal droplet shuttling in a microchannel toward a single line multiplexer with multiple sensors

Shimizu

Kakehi

Bono

et al. 2022

Sci Rep

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Multiple sensors and actuators integrated in a small space, especially an elongated thin structure, require equivalent number of signal lines between microdevices, but there is limited space for signal wires. Thus, we propose a mechanism using a single microchannel where a liquid metal droplet moves and shuttles. A shuttling droplet switches multiple terminals of signal lines along a microchannel based on a traditional switching mechanism using a liquid metal droplet. Electrically conductive gallium alloy liquid metals (Galinstan) can flow in a microchannel due to their fluidity. The terminals consist of opposing electrode pairs in a microchannel. A change in a variable impedance connected to a terminal as a pseudo sensor can be read when a droplet flows in and connects electrode pairs. This paper presents switching and addressing objective terminals of chromium electrodes by a shuttling conductive droplet (500 µm in diameter and 10 mm long) in a microchannel (500 µm in diameter and 100 mm long). A demonstrated simple mechanism enables communication between multiple microdevices along a microchannel. We anticipate wide application of proposed mechanism toward a multiplexer, especially in microfluidic devices because of the advantages of utilizing microchannels as common microstructures for both microdevices and signal lines.

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Optical fiber array based simultaneous parallel monitoring of resonant cantilever sensors in liquid

Cited by 7 publications

References 25 publications

Disposable cartridge biosensor platform for portable diagnostics

Disposable cartridge biosensor platform for portable diagnostics

Lock-in Amplifier Dairy Sensor for Detection of Ciprofloxacin

Liquid metal droplet shuttling in a microchannel toward a single line multiplexer with multiple sensors

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