Optical trapping for analytical biotechnology

Ashok, P.; Dholakia, Kishan

doi:10.1016/j.copbio.2011.11.011

Cited by 67 publications

(51 citation statements)

References 52 publications

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“…A breakthrough in the field of biophotonics, biophysics, and biotechnology was achieved in the last few decades, when OT became widely used as a tool for measuring the forces of cell and macromolecule interaction. 26 Bronkhorst et al 23 were the first to apply OT to study RBC aggregation. Although force measurements were not obtained, it was shown qualitatively that interaction is dependent on the suspension media, interaction time, and interaction area.…”

Section: Optical Tweezers To Probe the Red Blood Cell Aggregation Promentioning

confidence: 99%

Optical tweezers study of red blood cell aggregation and disaggregation in plasma and protein solutions

et al. 2016

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Abstract. Kinetics of optical tweezers (OT)-induced spontaneous aggregation and disaggregation of red blood cells (RBCs) were studied at the level of cell doublets to assess RBC interaction mechanics. Measurements were performed under in vitro conditions in plasma and fibrinogen and fibrinogen + albumin solutions. The RBC spontaneous aggregation kinetics was found to exhibit different behavior depending on the cell environment. In contrast, the RBC disaggregation kinetics was similar in all solutions qualitatively and quantitatively, demonstrating a significant contribution of the studied proteins to the process. The impact of the study on assessing RBC interaction mechanics and the protein contribution to the reversible RBC aggregation process is discussed.

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Section: Optical Tweezers To Probe the Red Blood Cell Aggregation Promentioning

confidence: 99%

Optical tweezers study of red blood cell aggregation and disaggregation in plasma and protein solutions

et al. 2016

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“…The ability of such techniques to manipulate and measure forces has found several applications such as understanding the dynamics of biological molecules, cell-cell interactions and the micro-rheology of both cells and fl uids [ 45 ]. A prime example is using optical tweezers to measure the interaction between NPs and prostate cancer cells [ 46 ].…”

Section: Optical Tweezersmentioning

confidence: 99%

Nanotechnology in Advanced Medical Devices

Habib-Ullah

Fei

2014

Nanomedicine

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“…147 Various approaches for the generation of optical beams that combines established techniques of holographic optical trapping with hollow intensity distributions have allowed the simultaneous stable trapping of multiple particles at defined pre-defined positions. 148,149 The optical stretcher is a novel, dual-beam optical trap that is capable of trapping and stretching dielectric particles, such as living biological cells, along the beam axis. Unlike conventional optical tweezing, which use a single focused beam to produce a point like trap, the optical stretcher uses diverging light spread across the particle surface.…”

Section: Transport Of Particles Using Optofluidic Waveguide Near Fieldsmentioning

confidence: 99%

Optofluidics incorporating actively controlled micro- and nano-particles

et al. 2012

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The advent of optofluidic systems incorporating suspended particles has resulted in the emergence of novel applications. Such systems operate based on the fact that suspended particles can be manipulated using well-appointed active forces, and their motions, locations and local concentrations can be controlled. These forces can be exerted on both individual and clusters of particles. Having the capability to manipulate suspended particles gives users the ability for tuning the physical and, to some extent, the chemical properties of the suspension media, which addresses the needs of various advanced optofluidic systems. Additionally, the incorporation of particles results in the realization of novel optofluidic solutions used for creating optical components and sensing platforms. In this review, we present different types of active forces that are used for particle manipulations and the resulting optofluidic systems incorporating them. These systems include optical components, optofluidic detection and analysis platforms, plasmonics and Raman systems, thermal and energy related systems, and platforms specifically incorporating biological particles. We conclude the review with a discussion of future perspectives, which are expected to further advance this rapidly growing field.

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Optical trapping for analytical biotechnology

Cited by 67 publications

References 52 publications

Optical tweezers study of red blood cell aggregation and disaggregation in plasma and protein solutions

Optical tweezers study of red blood cell aggregation and disaggregation in plasma and protein solutions

Nanotechnology in Advanced Medical Devices

Optofluidics incorporating actively controlled micro- and nano-particles

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