Based on a Bell Laboratories layered space-time (BLAST) technique, a room configuration model of the indoor multiple-input multiple-output (MIMO) infrared diffuse channels is established, and all the surface elements in the room are assumed to act as ambient light noise sources. The performance of two transmitters and two receivers MIMO ) 2 2 ( × system is compared against single-input singleoutput (SISO) system with the same total transmitter power. Numerical results show that different position leads to different bit error rate (BER) due to the variety of received ambient optical power. We also show that the MIMO ) 2 2 ( × system can achieve better bit error rate (BER) performance than the SISO system in the proposed diffuse channels model.