The study of multi-time-delay dynamical systems has highlighted many challenges, especially regarding the solution and analysis of multi-time-delay equations. The symmetry and conserved quantity are two important and effective essential properties for understanding complex dynamical behavior. In this study, a multi-time-delay non-conservative mechanical system is investigated. Firstly, the multi-time-delay Hamilton principle is proposed. Then, multi-time-delay non-conservative dynamical equations are deduced. Secondly, depending on the infinitesimal group transformations, the invariance of the multi-time-delay Hamilton action is studied, and Noether symmetry, Noether quasi-symmetry, and generalized Noether quasi-symmetry are discussed. Finally, Noether-type conserved quantities for a multi-time-delay Lagrangian system and a multi-time-delay non-conservative mechanical system are obtained. Two examples in terms of a multi-time-delay non-conservative mechanical system and a multi-time-delay Lagrangian system are given.