Optimal cut‐off point for homeostasis model assessment of insulin resistance to discriminate metabolic syndrome in non‐diabetic Japanese subjects

Yamada, Chizumi; Moriyama, Kengo; Takahashi, Eiji

doi:10.1111/j.2040-1124.2012.00194.x

Cited by 34 publications

(28 citation statements)

References 22 publications

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“…The HOMA-IR indices also indicated no insulin resistance in all subjects ( Table 5), except for non-sarcopenic subjects that were already diabetic. 22 We also examined the levels of FGF21, another growth factor associated with insulin resistance and type 2 diabetes, but found no significant differences in the postintervention subjects (Supporting Information, Table S2). Thus, it seems likely that the high insulin level post-intervention is not because of insulin resistance but because of improved insulin secretion, possibly because of the high levels of insulinogenic amino acids derived from whey protein.…”

Section: Changes In Circulating Factors After Intensive Lifestyle Intmentioning

confidence: 99%

Circulating factors associated with sarcopenia during ageing and after intensive lifestyle intervention

Shyh‐Chang

et al. 2019

J cachexia sarcopenia muscle

184

114

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Background Ageing, chronic diseases, prolonged inactivity, and inadequate nutrition pose a severe threat to skeletal muscle health and function. To date, experimental evidence suggests that ageing‐related subclinical inflammation could be an important causative factor in sarcopenia. Although inflammatory signalling has been implicated in the pathogenesis of experimental animal models of sarcopenia, few studies have surveyed the clinical association between circulating factors and muscle mass in patients before and after lifestyle interventions. In this study, we evaluated whether proinflammatory cytokines are associated with the onset of sarcopenia, which circulating factors are associated with the severity of sarcopenia, and how these factors change after lifestyle interventions in sarcopenic elderly persons. Methods A total of 56 elderly subjects (age ≥ 60 years) with sarcopenia and 56 elderly non‐sarcopenic subjects, who met entry criteria and had given informed consent, were selected from the Peking Union Medical College Hospital multicentre prospective longitudinal sarcopenia study for testing relevant circulating factors. Thirty‐two elderly subjects from the sarcopenic cohort completed a 12 week intensive lifestyle intervention programme with whey supplements (30 g/day) and a personalized resistance training regimen. The levels of proinflammatory cytokines and metabolic hormones, pre‐intensive and post‐intensive lifestyle interventions, were measured. Results The sarcopenic group was significantly older (72.05 ± 6.54 years; P < 0.001), more likely to be inactive and female (57.1% of all sarcopenic patients), and had a higher prevalence of type 2 diabetes (16% higher risk). Compared with non‐sarcopenic subjects, serum interleukin (IL)‐6, IL‐18, tumour necrosis factor‐α (TNF‐α), TNF‐like weak inducer of apoptosis (TWEAK), and leptin were significantly higher, while insulin growth factor 1, insulin, and adiponectin were significantly lower in sarcopenic patients (all P < 0.05). Logistic regression analyses revealed that high levels of TNF‐α (>11.15 pg/mL) and TWEAK (>1276.48 pg/mL) were associated with a 7.6‐fold and 14.3‐fold increased risk of sarcopenia, respectively. After adjustment for confounding variables, high levels of TWEAK were still associated with a 13.4‐fold increased risk of sarcopenia. Intensive lifestyle interventions led to significant improvements in sarcopenic patients' muscle mass and serum profiles of TWEAK, TNF‐α, IL‐18, insulin, and adiponectin (all P < 0.05). Conclusions High levels of the inflammatory cytokines TWEAK and TNF‐α are associated with an increased risk of sarcopenia, while the metabolic hormones insulin growth factor 1, insulin, and adiponectin are associated with a decreased risk of sarcopenia in our Chinese patient cohort. Intensive lifestyle interventions could signif...

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Section: Changes In Circulating Factors After Intensive Lifestyle Intmentioning

confidence: 99%

Circulating factors associated with sarcopenia during ageing and after intensive lifestyle intervention

Shyh‐Chang

et al. 2019

J cachexia sarcopenia muscle

184

114

View full text Add to dashboard Cite

show abstract

“…The results are significantly associated with the "gold standard", the glucose clamp results (4). The standard of insulin resistance index (HOMA-IR) was different in every race, every country (5)(6)(7)(8)(9)(10)(11)(12)(13)(14) . The cut-off values of HOMA-IR in a specific population should be defined, so that, we could know whether someone's HOMA-IR was normal or not (7,15).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of insulin resistance improvement after laparoscopic sleeve gastrectomy or gastric bypass surgery with HOMA-IR

Zhu

Sun

et al. 2017

BST

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“…The optimal cutoff point for HOMA‐IR in nondiabetic Japanese is also controversial. We determined 1.7 (lower than 2.5; ie, the general standard) as the optimal cutoff point . The reason is that, including the Japanese, the pancreatic beta cell of East Asians is not robust because East Asians are very sensitive to insulin.…”

Section: Discussionmentioning

confidence: 99%

“…We determined 1.7 (lower than 2.5; ie, the general standard) as the optimal cutoff point. 18 The reason is that, including the Japanese, the pancreatic beta cell of East Asians is not robust because East Asians are very sensitive to insulin. However, if there is even a slight decrease in insulin sensitivity, IR will generate among the East Asians who have no ability to increase insulin secretion further to compensate hyperglycemia.…”

Section: Why Has Ir Not Been Widely Used In Clinical Field? the Main mentioning

confidence: 99%

The association between insulin resistance, metabolic syndrome, and ischemic heart disease among Rumoi residents

Tan

Sasagawa

Mori

2017

J of Gen and Family Med

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BackgroundIt has widely been proven that metabolic syndrome (MetS) increases the risk of ischemic heart disease (IHD). MetS is confirmed based upon insulin resistance (IR). Our aim of this study is to evaluate the role of MetS and IR in the prediction of IHD incidence.MethodsA total of 404 non‐diabetic participants who underwent 75 g oral glucose tolerance test (75 g OGTT) were enrolled from 2001 to 2009. Risk factors for IHD were measured as well. The homeostatic index of IR (HOMA‐IR) and the homeostatic model assessment beta cell function (HOMA‐β) were calculated according to the homeostasis model assessment. Cox proportional‐hazard regression model was used to estimate hazard ratio (HR). All data were analyzed using SPSS 21 software (IBM, Armonk, NY, USA).ResultsIn our study, the average follow‐up period was 6.7 years. Eighteen subjects of IHD incidence were recorded. After adjusting for age and sex, subjects with IR or hyperinsulinemia had a high risk of IHD, the hazard ratio (95% confidence intervals) for IHD were 4.58 (1.59‐13.15), 4.25 (1.64‐11.91), respectively. The highest hazard ratio was 7.56 (2.27‐25.18) which was found among the subjects with both IR and hyperinsulinemia. In addition, the hazard ratio (95% confidence intervals) of subjects with MetS was 2.80(1.10‐7.09).Conclusions IR and hyperinsulinemia are related to the risk of IHD. IR combined with hyperinsulinemia may be superior to MetS for predicting the IHD incidence.

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Optimal cut‐off point for homeostasis model assessment of insulin resistance to discriminate metabolic syndrome in non‐diabetic Japanese subjects

Cited by 34 publications

References 22 publications

Circulating factors associated with sarcopenia during ageing and after intensive lifestyle intervention

Circulating factors associated with sarcopenia during ageing and after intensive lifestyle intervention

Evaluation of insulin resistance improvement after laparoscopic sleeve gastrectomy or gastric bypass surgery with HOMA-IR

The association between insulin resistance, metabolic syndrome, and ischemic heart disease among Rumoi residents

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