The association between insulin resistance, metabolic syndrome, and ischemic heart disease among Rumoi residents

Tan, Chek Tien; Sasagawa, Yutaka; Mori, Mitsuru

doi:10.1002/jgf2.94

Cited by 7 publications

(6 citation statements)

References 22 publications

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“…24 Several studies have shown that hyperinsulinemia and insulin resistance are independent predictors of ischemic heart disease. 25,26 Kaess et al. 27 reported that the relationship between the risk of CVD events and circulating levels of VEGF exhibits an inverted U shape.…”

Section: Discussionmentioning

confidence: 99%

“…24 Several studies have shown that hyperinsulinemia and insulin resistance are independent predictors of ischemic heart disease. 25,26 Kaess et al 27 reported that the relationship between the risk of CVD events and circulating levels of VEGF exhibits an inverted U shape. In addition, a higher VEGF level is presumed to serve as a compensatory response for atherosclerosis-related ischemia through the promotion of neovascularization.…”

Section: Discussionmentioning

confidence: 99%

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Serum vascular endothelial growth factor level is elevated in patients with impaired glucose tolerance and type 2 diabetes mellitus

et al. 2019

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Objective This study was performed to investigate the serum vascular endothelial growth factor (VEGF) levels in Chinese patients with impaired glucose tolerance (IGT) and newly diagnosed type 2 diabetes mellitus (T2DM). Methods A total of 189 subjects (41 controls, 40 patients with IGT, and 108 patients with newly diagnosed T2DM) were recruited. Serum VEGF levels were determined by ELISA; other metabolic parameters were assessed by standard laboratory methods. Results There were significant differences in serum VEGF levels among the T2DM, IGT, and control groups (T2DM vs. controls: 72.00 [45.40, 98.35] pg/mL vs. 53.10 [36.30, 116.25] pg/mL; IGT vs. controls: 78.17 [55.52, 137.25] pg/mL vs. 53.10 [36.30, 116.25] pg/mL). Moreover, serum VEGF levels were positively associated with the homeostasis model assessment for insulin resistance (HOMA-IR) value. Multiple linear regression analysis indicated that the HOMA-IR value was an independent risk factor for elevated serum VEGF level. Conclusions Both IGT and T2DM patients exhibited increased serum VEGF levels, compared with controls; increased serum VEGF level was positively associated with the HOMA-IR value. Therefore, the increased serum VEGF level might partially result from increased insulin resistance in these patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Serum vascular endothelial growth factor level is elevated in patients with impaired glucose tolerance and type 2 diabetes mellitus

et al. 2019

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“…IR involving multiple molecules and signaling mechanism, including insulin and its antagonist, insulin receptor substrates, phosphatidyl inositol 3 kinase (PI3K), glucose transporter gene and protein, mitogen-activated protein kinase (MAPK), etc (Seino et al, 2010). It has been proved that IR is the common pathological basis of abnormal glucose and lipid metabolism of essential hypertension, T2DM,coronary heart disease, hyperlipidemia and other diseases (Tan, Sasagawa & Mori, 2017;Otto et al, 2019). ROS include superoxide ionon (O 2− ), hydroxyl radical (OH − ) and hydrogen peroxide (H 2 O 2 ), among which O 2− has high activity and cytotoxicity and is mainly produced by aerobic microorganisms (Newsholme et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

lncRNA–mRNA competing endogenous RNA network in IR-hepG2 cells ameliorated by APBBR decreasing ROS levels: a systematic analysis

Lin

Mao

2020

PeerJ

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Background Radix Astragali (Astragalus membranaceus var. mongholicus (Bunge)) and Coptis chinensis (Coptis chinensis var. angustiloba) are two commonly prescribed traditional Chinese herbs for diabetes. Astragalus Polysaccharide (AP) and Berberine (BBR) are active ingredients of these two herbs respectively and they are scientifically proved to have immunomodulatory and anti-inflammatory effects. They are also known for their antidiabetic potential by ameliorating insulin resistance (IR). AP and BBR have shown different advantages in treating diabetes according to previous reports. However, very few studies focus on the combined activities of the two potential antidiabetic ingredients. In this study, we discovered that reactive oxygen species (ROS) accumulated in IR-hepG2 cells and APBBR can decrease ROS level in model group significantly. We conjectured that APBBR can ameliorate IR in hepG2 cells by decreasing ROS level. In order to verify this hypothesis, we obtained phenotype and transcriptome information of IR-HepG2 cells and explore the underlying mechanism of the combination of AP and BBR(APBBR) activity on the relationship between ROS change in IR at whole-transcriptome level, so as to shed new light to efficacy and application of APBBR in treating diabetes. Methods The IR cell model was established with high-level insulin intervention. Glucose content, HepG2 cell viability as well as ROS level was detected to study the effect of IR-hepG2 cell phenotype. Unbiased genome-wide RNA sequencing was used to investigate alterations in experimental groups. Then, GO and KEGG functional enrichment was performed to explore the function and pathway of target genes. Venn analysis found out the differentially expressed lncRNAs that had close relationship with IR and ROS. Finally, we screened out candidate lncRNAs and these target genes to construct interaction network of differentiated lncRNA–miRNA–mRNA by according to the principle of competitive endogenous RNA (ceRNA). Results The biochemical experiments showed that APBBR administration could improve the proliferation activity of IR-HepG2 cells and decrease ROS level in model cells. The GO and KEGG functional enrichment analyses demonstrated several mRNAs remarkably enriched in biological processes and signaling pathways related to ROS production and IR progression. Interaction network suggest that APBBR ameliorates IR in HepG2 cells by regulating the expression of multiple genes and activating relevant signaling pathway to decrease ROS level. Thus, we demonstrated that APBBR ameliorated IR in hepG2 cells via the ROS-dependent pathway.

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“…TyG index is a useful surrogate marker for insulin resistance, [25] which is independently associated with the presence of coronary artery atherosclerosis; [29] notably, this parameter was recently shown to be an important risk factor for IHD. [30,31] Insulin resistance leads to a relative reduction of insulin action, then to hyperglycemia and consequently to higher production of insulin by pancreatic β-cells.…”

Section: Discussionmentioning

confidence: 99%

The Syntaxin-1A gene single nucleotide polymorphism rs4717806 associates with the risk of ischemic heart disease

et al. 2019

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Ischemic heart disease (IHD) has a genetic predisposition and a number of cardiovascular risk factors are known to be affected by genetic factors. Development of metabolic syndrome and insulin resistance, strongly influenced by lifestyle and environmental factors, frequently occur in subjects with a genetic susceptibility. The definition of genetic factors influencing disease susceptibility would allow to identify individuals at higher risk and thus needing to be closely monitored. To this end, we focused on a complex of soluble-N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs), playing an important role in metabolic syndrome and insulin resistance, involved in endothelial dysfunction and heart disease. We assessed if genetic variants of the SNARE genes are associated with IHD. SNAP25 rs363050 , Stx-1A rs4717806 , rs2293489 , and VAMP2 26bp ins/del genetic polymorphisms were analyzed in a cohort of 100 participants who underwent heart surgery; 56 of them were affected by IHD, while 44 were not. A statistical association of plasma glycemia and insulin resistance, calculated as Triglyceride glucose (TyG) index, was observed in IHD ( P < .001 and P = .03, respectively) after binomial logistic stepwise regression analysis, adjusted by age, gender, diabetes positivity, waist circumference, and cholesterol plasma level. Among genetic polymorphisms, rs4717806(A) and rs2293489(T) , as well as the rs4717806 – rs2293489 (A-T) haplotype were associated with higher risk for IHD ( Pc = .02; Pc = .02; P = .04, respectively). Finally, a statistical association of rs4717806(AA) genotype with higher TyG index in IHD patients ( P = .03) was highlighted by multiple regression analysis considering log-transformed biochemical parameters as dependent variable and presence of coronary artery disease, age, gender, waist circumference, presence of diabetes as predictors. These results point to a role of the Stx-1A rs4717806 SNP in IHD, possibly due to its influence on Stx-1A expression and, as a consequence, on insulin secretion and glucose metabolism.

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The association between insulin resistance, metabolic syndrome, and ischemic heart disease among Rumoi residents

Cited by 7 publications

References 22 publications

Serum vascular endothelial growth factor level is elevated in patients with impaired glucose tolerance and type 2 diabetes mellitus

Serum vascular endothelial growth factor level is elevated in patients with impaired glucose tolerance and type 2 diabetes mellitus

lncRNA–mRNA competing endogenous RNA network in IR-hepG2 cells ameliorated by APBBR decreasing ROS levels: a systematic analysis

The Syntaxin-1A gene single nucleotide polymorphism rs4717806 associates with the risk of ischemic heart disease

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