A novel distributed PZT control strategy based on characteristic model is presented for space frame structure in this paper. It is a challenge to obtain the exact mechanical model for space structure, since it is a coupling MIMO plant with unknown parameters and disturbances. Thus the characteristic modeling theory is adopted to establish the needed model, which can accurately describe the dynamic characteristics of the space frame structure in real time. On basis of this model, a keep tracking controller is designed to suppress the vibration actively. It is shown that the proposed model-free method is very robust and easy to implement. To solve the complex and difficulty problem on PZT location optimization, an efficient method with modal strain energy and maximum vibration amplitude is proposed. Finally, a simulation study is conducted to investigate the effectiveness of the proposed active vibration control scheme.