“…2 (c)). Further information on NP characterizations has been reported in our previous publications [ [25] , [26] , [27] ]. Fig.…”
Section: Resultsmentioning
confidence: 99%
“…The SPIO@AuNP-Cisplatin-Alginate (SACA) nanocomplex was prepared as previously described [ 17 , [25] , [26] , [27] ]. Using a modified version of Massart's co-precipitation method, Fe3O4 NPs were synthesized [ 28 ].…”
Section: Methodsmentioning
confidence: 99%
“…Also, the Malvern Zetasizer Nano ZS-90 instrument was used to measure the hydrodynamic diameter and Zeta potential distribution of the nanocapsules that had been made. The release profile of the SACA nanocomplex has been measured in our previous studies [ [25] , [26] , [27] ].…”
Section: Methodsmentioning
confidence: 99%
“…After reaching cells at about 90% confluency, the medium of each well was changed, and cisplatin and SACA were added at different concentrations and incubated for 4 h at the standard conditions. Based on the pilot studies and previous experiments with the SPIO@AuNP-Alginate nanocomplex [ [25] , [26] , [27] ], we chose 4 h of incubation. Tests were repeated in six wells for each concentration and incubated for 4 h. Instantly thereafter, the percentage of cell death is evaluated using the MTT assay.…”
“…2 (c)). Further information on NP characterizations has been reported in our previous publications [ [25] , [26] , [27] ]. Fig.…”
Section: Resultsmentioning
confidence: 99%
“…The SPIO@AuNP-Cisplatin-Alginate (SACA) nanocomplex was prepared as previously described [ 17 , [25] , [26] , [27] ]. Using a modified version of Massart's co-precipitation method, Fe3O4 NPs were synthesized [ 28 ].…”
Section: Methodsmentioning
confidence: 99%
“…Also, the Malvern Zetasizer Nano ZS-90 instrument was used to measure the hydrodynamic diameter and Zeta potential distribution of the nanocapsules that had been made. The release profile of the SACA nanocomplex has been measured in our previous studies [ [25] , [26] , [27] ].…”
Section: Methodsmentioning
confidence: 99%
“…After reaching cells at about 90% confluency, the medium of each well was changed, and cisplatin and SACA were added at different concentrations and incubated for 4 h at the standard conditions. Based on the pilot studies and previous experiments with the SPIO@AuNP-Alginate nanocomplex [ [25] , [26] , [27] ], we chose 4 h of incubation. Tests were repeated in six wells for each concentration and incubated for 4 h. Instantly thereafter, the percentage of cell death is evaluated using the MTT assay.…”
“…Furthermore, the size, shape, surface functionalization, concentration, and intracellular distribution of AuNPs can influence their effect on radiation [29][30][31][32]. In 2020, in our department, in a published paper [33], authors synthesized applied alginate-coated iron oxide-gold core-shell nanoparticles (Fe 3 O 4 @Au/Alg NPs) for synergistic photo-thermoradiotherapy. They found that the presence of gold nanoparticles in the synthesized nanocomposite significantly improves the photothermal efficiency and dose-enhancement of X-rays to a great extent.…”
In recent years, there has been an increasing interest in using nanoparticles in the medical sciences. Today, metal nanoparticles have many applications in medicine for tumor visualization, drug delivery, and early diagnosis, with different modalities such as X-ray imaging, computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET), etc., and treatment with radiation. This paper reviews recent findings of recent metal nanotheranostics in medical imaging and therapy. The study offers some critical insights into using different types of metal nanoparticles in medicine for cancer detection and treatment purposes. The data of this review study were gathered from multiple scientific citation websites such as Google Scholar, PubMed, Scopus, and Web of Science up through the end of January 2023. In the literature, many metal nanoparticles are used for medical applications. However, due to their high abundance, low price, and high performance for visualization and treatment, nanoparticles such as gold, bismuth, tungsten, tantalum, ytterbium, gadolinium, silver, iron, platinum, and lead have been investigated in this review study. This paper has highlighted the importance of gold, gadolinium, and iron-based metal nanoparticles in different forms for tumor visualization and treatment in medical applications due to their ease of functionalization, low toxicity, and superior biocompatibility.
Radiosensitizers are compounds or nanostructures, which can improve the efficiency of ionizing radiation to kill cells. Radiosensitization increases the susceptibility of cancer cells to radiation‐induced killing, while simultaneously reducing the potentially damaging effect on the cellular structure and function of the surrounding healthy tissues. Therefore, radiosensitizers are therapeutic agents used to boost the effectiveness of radiation treatment. The complexity and heterogeneity of cancer, and the multifactorial nature of its pathophysiology has led to many approaches to treatment. The effectiveness of each approach has been proven to some extent, but no definitive treatment to eradicate cancer has been discovered. The current review discusses a broad range of nano‐radiosensitizers, summarizing possible combinations of radiosensitizing NPs with several other types of cancer therapy options, focusing on the benefits and drawbacks, challenges, and future prospects.
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