Optimasi Formula Sediaan Losion Tabir Surya dari Ekstrak Etanol Terpurifikasi Kulit Buah Manggis (Garcinia mangostana L) Dengan Metode Simplex Lattice Design

Iryani, Yeyen Dwi; Astuti, Ika Yuni; Diniatik, Diniatik

doi:10.25077/jsfk.8.2.145-156.2021

Cited by 6 publications

(7 citation statements)

References 10 publications

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“…The thick extract of Vernonia amygdalina Del leaves was then extracted using a mixture of distilled water and N-hexane in the same ratio. The purpose of adding the solvent is to remove impurities that are attracted during extraction such as fats and pigments that are not needed (Iryani et al, 2021). The results of the phytochemical screening test are listed in Table 2.…”

Section: Resultsmentioning

confidence: 99%

“…The filtrate obtained was concentrated using a rotary evaporator to obtain a thick extract. The Vernonia amygdalina Del leaf extract was then purified with n-hexane and water (1:1) in a separating funnel, shaken and left to form two layers, then evaporated to obtain a purified Vernonia amygdalina Del leaf extract (Iryani et al, 2021).…”

Section: Extractionmentioning

confidence: 99%

“…The vitamin C test solution and the Vernonia amygdalina Del leaf extract test solution was prepared by weighing 5 mg of vitamin C and the purified Vernonia amygdalina Del leaf extract and dissolved using methanol p.a to a concentration of 100 µg/mL then pipetting 0.1;0.2;0.3;0.4 mL and 0.5mL into a 5mL flask and add 2mL of DPPH and methanol p.a up to the mark. This solution was then incubated for 10 minutes and its absorbance was measured at the max DPPH wavelength (Iryani et al, 2021).…”

Section: Antioxidant Activitymentioning

confidence: 99%

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ANTIOXIDANT ACTIVITY TEST OF AFRICAN LEAVES PURIFICATION EXTRACT (Vernonia amygdalina Del) WITH DPPH METHOD

Karlina

Kunaedi

Ahidin

et al. 2023

JFSP

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African leaves (Vernonia amygdalina Del) is a plant that can be used as a medicinal plant because it contains flavonoid compounds that are effective as natural antioxidants that can suppress free radicals. The purpose of this study was to determine the antioxidant activity of the purified extract of Vernonia amygdalina Del. Antioxidant activity test of purified extract of Vernonia amygdalina Del leaves against 1,1-diphenyl-2-picrylhydrazil (DPPH) was measured with a UV-Vis spectrophotometer at a wavelength of 516nm using Vitamin C as a comparison. The results of the non-specific parameters of Vernonia amygdalina Del leaf Simplicia were drying shrinkage of 0.79±0.02%; water content of 7.33±2.08%; water-soluble essence content of 20.5±1.73 %; and ethanol of 14.5±4.35 %. The results of purified extract screening of Vernonia amygdalina Del leaves, contained chemical compounds, namely the class of flavonoid compounds, tannin compounds, steroid compounds, and saponin compounds. Testing for flavonoids using the Thin Layer Chromatography method on the purified extract contained two spots with Rf values of 0.68 and 0.5 while in quercetin there was one spot with an Rf value of 0.68, thus the purified extract of Vernonia amygdalina Del leaves contained flavonoids. Vernonia amygdalina Del leaf purified extract has a very strong antioxidant activity with an IC50 value of 13.54±0.10 µg/mL. The results showed that the purified extract of Vernonia amygdalina Del leaves had very strong antioxidant activity.

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Section: Resultsmentioning

confidence: 99%

Section: Extractionmentioning

confidence: 99%

Section: Antioxidant Activitymentioning

confidence: 99%

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ANTIOXIDANT ACTIVITY TEST OF AFRICAN LEAVES PURIFICATION EXTRACT (Vernonia amygdalina Del) WITH DPPH METHOD

Karlina

Kunaedi

Ahidin

et al. 2023

JFSP

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“…Both possess UV absorption at a wavelength around 200-400 nm (Kumar et al, 2016;Ahmad et al, 2013). Based on the previous research, the SPF value of the ethanolic extracts of avocado leaves and mangosteen peel is still below 15 (14.45 and 8.94) which is the minimum SPF value recommended by the FDA (Pontoan, 2016;Iryani et al, 2021). Therefore, in this study, we combined the natural active substances with OMC.…”

Section: Introductionmentioning

confidence: 99%

Optimization of Sunscreen Cream Formulation Containing Ethanolic Extract of Avocado Leaves (Persea americana Mill.) or Mangosteen Rind (Garcinia mangostana L.) Combined with Octyl Methoxycinnamate

Verda,

Leonardo,

Prismawan

et al. 2023

JFG

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Background: Most sunscreens contain chemicals that can cause health and environmental problems. Natural actives can be an alternative to minimize the use of chemicals. Avocado leaves (Persea americana Mill.) and mangosteen peel (Garcinia mangostana L.) contain active compounds that have UV absorption. Objective: In this study, the optimal composition of a mixture of ethanol extracts of avocado leaves or mangosteen peel with octyl methoxycinnamate (OMC) was determined based on the Sun Protection Factor (SPF) and adhesive properties using Response Surface Methodology (RSM). Material and method: The optimal formula calculated with RSM was then made and underwent a series of tests, including a hedonic test with a scale of 0-9 on 30 respondents, a freeze-thaw stability test, and an accelerated stability test with the Arrhenius equation. Results: The RSM analysis showed that the optimal concentration of extract and OMC was 10% and 0.75% (avocado leaves) & 0.65% (mangosteen peel). The optimized formula resulted in adhesive properties and SPF of 7.41±0.03 and 16.52±0.16 (avocado leaves) & 7.43±0.04 and 15.84±0.15 (mangosteen peel) respectively. Both optimized formulations were physically stable against freeze-thaw and had a t90 of 29 minutes (avocado leaves) and 17 minutes (mangosteen peel). The average hedonic scale obtained was 7.8 (avocado leaves) and 7.9 (mangosteen peel), indicating that both optimized formulations were preferred by the respondents. Conclusions: The sunscreen formulation with an optimized combination of active ingredients from avocado leaf extract or mangosteen peel extract with OMC using RSM results in preparation with SPF value and physical properties that meet the requirements.

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“…The diversification of personal care products, particularly body lotions, underscores the utilization of substitute ingredients as active agents. Previous studies explored formulations like essential oils as anti-mosquito lotions, stevia leaf extract as sunscreen lotion, ethanol extract of mangosteen peel as sunscreen lotion, gotu kola extract, and katuk leaf extract [3]; [4]; [5]; [6]; [7]. Some studies investigated emulsifiers as variables, including stearyl alcohol ethoxylate emulsifiers and emulsifiers from triethanolamine [8]; [9].…”

Section: Introductionmentioning

confidence: 99%

Formulation of Body Lotion with Sucrose Ester Emulsifier

Suha Aditha,

Hambali,

Purnawati

et al. 2024

IOP Conf. Ser.: Earth Environ. Sci.

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Sucrose ester is synthesized from palm fatty acid methyl ester and sucrose using a base catalyst. Emulsifiers that replace palm oil with sucrose esters are biodegradable and potentially non-toxic to the skin. The efficiency of sucrose ester production was obtained by using water as a solvent for sucrose, with a mass ratio of 3:5 for water and sucrose. Dilution of sucrose with water reduces caramelization during reaction. Based on laboratory research, sucrose ester has good emulsion stability from sucrose myristate ester, sucrose palmitate ester, and sucrose laurate ester. The design used a random block design with three levels of variation in sucrose ester concentration, namely 2%, 6%, and 10%. Based on ANOVA, there is a very significant effect between variations in concentration on specific gravity, pH, viscosity and surface tension. Verification tests were carried out on consumer references in the form of organoleptic tests on 35 respondents. Then, microbial tests are carried out based on Indonesian National Standards, namely the maximum number of total plates (10−2 colonies), negative tests for fungi, Staphylococcus aureus, Pseudomonas aeruginosa, and Coliform (maximum 3). Determining the best combination uses the Composite Performance Index (CPI) and Analytical Hierarchy Process (AHP). Based on organoleptic tests, the best sample is 10% myristate. The analysis of organoleptic results is consistent with the analysis of laboratory results which states that the lotion sample made from 10% sucrose myristate ester is the best sample. The best lotion samples have good emulsion stability and are not contaminated by microbes.

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Optimasi Formula Sediaan Losion Tabir Surya dari Ekstrak Etanol Terpurifikasi Kulit Buah Manggis (Garcinia mangostana L) Dengan Metode Simplex Lattice Design

Cited by 6 publications

References 10 publications

ANTIOXIDANT ACTIVITY TEST OF AFRICAN LEAVES PURIFICATION EXTRACT (Vernonia amygdalina Del) WITH DPPH METHOD

ANTIOXIDANT ACTIVITY TEST OF AFRICAN LEAVES PURIFICATION EXTRACT (Vernonia amygdalina Del) WITH DPPH METHOD

Optimization of Sunscreen Cream Formulation Containing Ethanolic Extract of Avocado Leaves (Persea americana Mill.) or Mangosteen Rind (Garcinia mangostana L.) Combined with Octyl Methoxycinnamate

Formulation of Body Lotion with Sucrose Ester Emulsifier

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