Optimasi Formulasi Gel Ekstrak Daun Tembakau (Nicotiana Tabacum) Dengan Variasi Kadar Karbopol940 Dan Tea Menggunakan Metode Simplex Lattice Design (Sld)

Rahayu, Titis; Fudholi, Achmad; Fitria, Annisa

doi:10.20885/jif.vol12.iss1.art3

Cited by 12 publications

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“…The function of TEA here is not as a gelling agent but as an alkylating agent related to the formation of pH and gel matrix through the formation of polymer chain [14]. SLD research results also showed that carbopol 940 mixed with TEA had a positive effect on gel formation with a coefficient value of 20869 [16]. ).…”

Section: A Effect Of Carbopol 940 On the Physical Properties Of Gel mentioning

confidence: 91%

“…The research conducted with SLD method was obtained the simplex lattice design equation Y = 0.315 (A) + 0.244 (B) + 0.035 (A) (B) which showed that the proportion of carbopol 940 gives a positive response with a coefficient value of 0.315 which can increase great adhesion compared to TEA (0.244 ). Mixing between carbopol 940 and TEA in the preparation showed a positive coefficient value of 0.035, both of these components were able to increase the value of the adhesion of gel preparations [16]. Carbopol 940 consists of long chain polymers.…”

Section: A Effect Of Carbopol 940 On the Physical Properties Of Gel mentioning

confidence: 95%

“…According to research conducted by Rahmawati and Setiawan, it showed that carbopol 940 affected the viscosity of gel preparations with consecutive viscosity results for concentrations of 0.5; 1; 1,5; 2, namely 130 dpas, 150 dpas, 175 dpas and 280 dpas [15]. The results of research conducted with the Simplex Lattice Design (SLD) method showed that carbopol 940 had a positive effect on the viscosity of gel preparations with a carbopol 940 coefficient of from 6098 compared to Triethanolamine which had a negative effect with a TEA coefficient of 6960 [16]. The function of TEA here is not as a gelling agent but as an alkylating agent related to the formation of pH and gel matrix through the formation of polymer chain [14].…”

Section: A Effect Of Carbopol 940 On the Physical Properties Of Gel mentioning

confidence: 99%

“…Therefore, the absorption of the drug to the skin occurs quickly [19]. The SLD equation for the spread response in research conducted by Rahayushowed the comparison of the proportion of TEA (7.52) was able to provide a positive response to increase the spread value of the gel compared to carbopol (3.45) [16].…”

Section: A Effect Of Carbopol 940 On the Physical Properties Of Gel mentioning

confidence: 99%

“…Mixing between the components of the carbopol fraction and the TEA fraction gave a negative response with a coefficient of 5.19 for the response of the gel spreadability [16]. In other research, it was also found that the higher concentration of carbopol 940 could reduce the spreadability with consecutive value of 15.33887 cm; 10, 7749 cm; 10,139 cm; 8.003 cm at carbopol concentration of 940 0.5; 1; 1.5 and 2 [15].…”

Section: A Effect Of Carbopol 940 On the Physical Properties Of Gel mentioning

confidence: 99%

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Overview: Application of Carbopol 940 in Gel

Safitri¹,

Nawangsari²,

Febrina³

2021

Proceedings of the International Conference on Health and Medical Sciences (AHMS 2020)

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Carbopol is an acrylic polymer. Carbopol is non-toxic and non-irritating so that it is suitable for gel preparations. Carbopol 940 is often used as a gelling agent in gel preparations. Concentration of carbopol 940 as a gelling agent needs to be concerned to obtain a good gel preparation. This study aimed to determine the effect of carbopol 940 concentration on physical properties, drug release and the use in eye drops. The research method used was descriptive method with data collection technique using PICO (Population, Intervention, Compare, Outcame) approach. Based on the Descriptive research results, it was obtained that carbopol 940 had influences on the physical properties of the gel in the form of pH, viscosity, spreadability, adhesion, organoleptic and stability. Carbopol 940 is commonly used in controlled-release drug formulations. In addition, carbopol 940 is also safe to use in eye drops preparations which do not cause irritation in in vivo testing.

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Section: A Effect Of Carbopol 940 On the Physical Properties Of Gel mentioning

confidence: 91%

Section: A Effect Of Carbopol 940 On the Physical Properties Of Gel mentioning

confidence: 95%

Section: A Effect Of Carbopol 940 On the Physical Properties Of Gel mentioning

confidence: 99%

Section: A Effect Of Carbopol 940 On the Physical Properties Of Gel mentioning

confidence: 99%

Section: A Effect Of Carbopol 940 On the Physical Properties Of Gel mentioning

confidence: 99%

See 3 more Smart Citations

Overview: Application of Carbopol 940 in Gel

Safitri¹,

Nawangsari²,

Febrina³

2021

Proceedings of the International Conference on Health and Medical Sciences (AHMS 2020)

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Optimization of Cream Ethanol Extract of Duku Leaves (Lansium domesticum Corr.) as Antibacterial Against Staphylococcus aureus Using the Simplex Lattice Design Method

Saryanti,

Prameswari

2024

SMedJour

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Introduction: The secondary metabolites flavonoids and triterpenoids in duku leaves have antimicrobial properties. Cream have some drawbacks, including fragility to erratic stirring, brittleness when dried up, and poor storage stability. Triethanolamine reacts with stearic acid will form triethanolamine stearate which can increase stability of the cream. This research aimed to find the ideal ratio of stearic acid to triethanolamine for making an antibacterial composition.Methods: Optimization of the cream is carried out by Simplex Lattice Design method, made 8 run with the smallest proportion of stearic acid 15g and the highest 17g, and the smallest proportion of triethanolamine 2g and the highest 4g. Responses used in Simplex Lattice Design, namely pH, viscosity, adhesion, and spreadability. T-test was used to verification of the optimal formula and ANOVA was used to analysis of antibacterial data.Results: The optimal formula was 17 grams of stearic acid and 2 grams of triethanolamine make the optimal cream. The test results show that there is no significant difference between the optimal formula and the predictions in the Simplex Lattice Design software, with a pH of 6.33±0.033, a viscosity of 179.67±0.333, an adhesion of 1.377±0.038, and a spreadability of 5.133±0.044. The best formula has moderate antibacterial activity (6.62±0.007 mm inhibition zone) against Staphylococcus aureus.Conclusion: The optimal formula has good physical properties and is efficacious as an antibacterial.

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OPTIMASI BASIS HPMC DAN NA CMC DALAM SEDIAAN GEL KULIT BUAH SEMANGKA (Citrullus lanatus) SERTA UJI AKTIVITAS ANTIBAKTERINYA TERHADAP Staphylococcus aureus

Wijayanti,

Nurwaini

2023

ujp

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Staphylococcus aureus menyebabkan penyakit kulit yaitu jerawat. Kulit buah semangka (Citrullus lanatus) mengandung senyawa fenolik yang memiliki aktivitas antibakteri terhadap Staphylococcus aureus. Kulit buah semangka diformulasikan menjadi gel agar mudah diaplikasikan pada kulit. Tujuan dari penelitian ini adalah untuk mengoptimalkan basis gel yaitu HPMC dan Na CMC agar diperoleh sifat fisik gel yang optimum. Optimasi ini menggunakan aplikasi Design Expert versi 13.0 (Trial) dengan metode Simplex Lattice Design. Berdasarkan penelitian ini, HPMC memiliki pengaruh yang lebih besar terhadap daya sebar dibandingkan Na CMC yang berpengaruh besar terhadap pH, daya lekat, dan viskositas. Formula optimum yang diperoleh adalah kombinasi 4% HPMC dan 1% Na CMC. Formula prediksi dibandingkan dengan formula verifikasi menggunakan aplikasi IBM Statistic versi 25 dengan metode one sample t-test dengan tingkat kepercayaan 95% untuk parameter yang diuji (pH, daya lekat, daya sebar, dan viskositas). Hasil analisis statistik menunjukkan bahwa parameter pH, daya lekat, daya sebar, dan viskositas tidak berbeda signifikan sehingga metode optimasi dapat memprediksi semua parameter secara valid. Gel ekstrak kulit semangka (Citrullus lanatus) memiliki aktivitas antibakteri terhadap S. aureus dengan zona hambat 15,29 mm termasuk kategori intermediet.

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Optimasi Formulasi Gel Ekstrak Daun Tembakau (Nicotiana Tabacum) Dengan Variasi Kadar Karbopol940 Dan Tea Menggunakan Metode Simplex Lattice Design (Sld)

Cited by 12 publications

References 0 publications

Overview: Application of Carbopol 940 in Gel

Overview: Application of Carbopol 940 in Gel

Optimization of Cream Ethanol Extract of Duku Leaves (Lansium domesticum Corr.) as Antibacterial Against Staphylococcus aureus Using the Simplex Lattice Design Method

OPTIMASI BASIS HPMC DAN NA CMC DALAM SEDIAAN GEL KULIT BUAH SEMANGKA (Citrullus lanatus) SERTA UJI AKTIVITAS ANTIBAKTERINYA TERHADAP Staphylococcus aureus

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