Optimization and characterization of a novel tea tree oil-integrated poly (ε-caprolactone)/soy protein isolate electrospun mat as a wound care system

Doustdar, Fatemeh; Ramezani, Soghra; Ghorbani, Marjan; Moghadam, Fatemeh Mortazavi

doi:10.1016/j.ijpharm.2022.122218

Cited by 24 publications

(12 citation statements)

References 64 publications

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“…According to the authors, this asymmetric film could be of great importance in wound healing and related soft tissue regeneration. Doustdar et al [ 139 ] produced poly (ε-caprolactone)/soy protein isolate (PCL/SPI, 95:5) mats with different concentrations of TTO (6, 12, and 20%), using the electrospinning method. The release profiles showed that higher amounts of TTO in the mats could be released in an acidic environment and the antioxidant activity of the mats increased by the increase in their TTO content (PCL/SPI TTO 6%, PCL/SPI TTO 12%, PCL/SPI TTO 20%, the inhibitions percentages, measured through the DPPH method, were 30, 45, and 65%, respectively).…”

Section: Antioxidant Properties Of Ttomentioning

confidence: 99%

Tea Tree Oil: Properties and the Therapeutic Approach to Acne—A Review

et al. 2023

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Acne vulgaris is an inflammatory dermatological pathology that affects mostly young people. However, it can also appear in adulthood, mainly in women. It has a high psychosocial impact, not only at the time of active lesions but also due to the consequences of lesions such as scarring and hyperpigmentation. Several factors are involved in the physiopathology of acne and the constant search for active ingredients is a reality, namely phytotherapeutic ingredients. Tea tree oil is an essential oil extracted from Melaleuca alternifolia (Maiden & Betch) Cheel with known antibacterial, anti-inflammatory, and antioxidant properties, making it a candidate for the treatment of acne. This review aims to describe the various properties of tea tree oil that make it a possible ingredient to use in the treatment of acne and to present several human studies that have evaluated the efficacy and safety of using tea tree oil in the treatment of acne. It can be concluded that tea tree oil has good antibacterial, anti-inflammatory, and antioxidant properties that result in a decrease in the number of inflammatory lesions, mainly papules, and pustules. However, given the diversity of study designs, it is not possible to draw concrete conclusions on the efficacy and safety of this oil in the treatment of acne.

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Section: Antioxidant Properties Of Ttomentioning

confidence: 99%

Tea Tree Oil: Properties and the Therapeutic Approach to Acne—A Review

et al. 2023

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“…Confirming biocompatibility of electrospun fibers using tissue culture is a crucial step in evaluation of their biomedical relevance. SP/PCL blend containing tea tree oil showed antioxidant, antibacterial, and mouse fibroblast growth-supporting properties [ 71 ]. Electrospun mats fabricated of SP and PVA fibers with analgesic drug ketoprofen-preloaded tubular mineral sepiolite, demonstrated increased mechanical strength, and a much better drug release profile [ 72 ].…”

Section: Recent Trends In Biomedical Application Of Electrospun Plant...mentioning

confidence: 99%

Agro-Industrial Plant Proteins in Electrospun Materials for Biomedical Application

et al. 2023

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Plant proteins are receiving a lot of attention due to their abundance in nature, customizable properties, biodegradability, biocompatibility, and bioactivity. As a result of global sustainability concerns, the availability of novel plant protein sources is rapidly growing, while the extensively studied ones are derived from byproducts of major agro-industrial crops. Owing to their beneficial properties, a significant effort is being made to investigate plant proteins’ application in biomedicine, such as making fibrous materials for wound healing, controlled drug release, and tissue regeneration. Electrospinning technology is a versatile platform for creating nanofibrous materials fabricated from biopolymers that can be modified and functionalized for various purposes. This review focuses on recent advancements and promising directions for further research of an electrospun plant protein-based system. The article highlights examples of zein, soy, and wheat proteins to illustrate their electrospinning feasibility and biomedical potential. Similar assessments with proteins from less-represented plant sources, such as canola, pea, taro, and amaranth, are also described.

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“…To overcome these drawbacks, some strategies have been proposed, such as protein crosslinking and/or blending with synthetic polymers. [12][13][14][15] Most of the SPI-based nanofibers reported in the literature are water-soluble systems and require a crosslinking reaction to improve their water stability. Typically, bifunctional crosslinkers, such as aldehyde compounds, commonly react with reactive groups present in the protein chain (i.e., primary amine, carboxyl, hydroxyl, and sulfhydryl groups) and are often used as crosslinking agents.…”

Section: Introductionmentioning

confidence: 99%

“…Electrospun SPI systems nonetheless show low mechanical integrity and low water stability. To overcome these drawbacks, some strategies have been proposed, such as protein crosslinking and/or blending with synthetic polymers 12–15 …”

Section: Introductionmentioning

confidence: 99%

Effect of thermal treatments and UV radiation on green soy protein isolated crosslinked electrospun mats

Cunha

Ponce

Abraham

2023

J of Applied Polymer Sci

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Plant‐derived proteins continue to draw great interest due to their high availability, biodegradability, and biological properties. Among them, soy protein isolate (SPI) has been explored for the development of different sustainable and biodegradable materials in many bionanotechnological fields. In addition, the electrospinning technique has gained interest as a versatile platform for designing synthetic/biopolymer‐based nanofibrous mats for a huge variety of bionanotechnological fields. However, the water stability of SPI mats is low, and the sterilization procedures and conditions are not well established. In this work, oxidized sucrose (OS) was used as a green and inexpensive crosslinker for electrospun SPI mats. The sugar oxidation process was optimized by varying hydrogen peroxide concentration and reaction temperature. SPI‐OS solutions were electrospun using acetic acid as a benign solvent and the resulting mats were thermally treated at mild temperatures and different times. The crosslinked structures were fully characterized in terms of fiber morphology, and physicochemical and thermal properties. Interestingly, uniform bead‐free nanofibrous SPI‐OS membranes that retained their fibrous morphology after 7 days of immersion in phosphate‐buffered saline were successfully obtained. In addition, bilayered SPI‐OS/polycaprolactone mats were also produced by green electrospinning and sterilized by UV radiation for different exposure times. Finally, the effect of sterilization on the relevant properties was presented and discussed. UV radiation demonstrated to be an effective method for sterilizing crosslinked SPI‐based nanofibrous structures.

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Optimization and characterization of a novel tea tree oil-integrated poly (ε-caprolactone)/soy protein isolate electrospun mat as a wound care system

Cited by 24 publications

References 64 publications

Tea Tree Oil: Properties and the Therapeutic Approach to Acne—A Review

Tea Tree Oil: Properties and the Therapeutic Approach to Acne—A Review

Agro-Industrial Plant Proteins in Electrospun Materials for Biomedical Application

Effect of thermal treatments and UV radiation on green soy protein isolated crosslinked electrospun mats

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