Optimization and evaluation of the signal intensity change in multisection oxygen-enhanced MR lung imaging

Löffler, Ralf; Müller, Christian; Peller, Michael; Penzkofer, H.; Deimling, M.; Schwaiblmair, Martin; Scheidler, Jürgen; Reiser, Maximilian

doi:10.1002/1522-2594(200006)43:6<860::aid-mrm12>3.0.co;2-c

Cited by 96 publications

(85 citation statements)

References 17 publications

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“…Preliminary oxygenenhanced measurements at 3 Tesla resulted in T 1 values of 1281 ms and 1102 ms when breathing room air and pure oxygen, respectively [34]. Since there is no clear trend towards longer T 1 relaxation times at 3 Tesla compared to 1.5 Tesla, it appeared reasonable to choose the same optimal inversion time [30] for both field strengths. The echo time was chosen to be as short as possible at both field strengths to minimize the T 2-weighting of the sequence.…”

Section: Discussionmentioning

confidence: 99%

Oxygen-Enhanced MRI of the Lungs: Intraindividual Comparison Between 1.5 and 3 Tesla

Thieme

Dietrich

Maxien

et al. 2011

Fortschr Röntgenstr

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Section: Discussionmentioning

confidence: 99%

Oxygen-Enhanced MRI of the Lungs: Intraindividual Comparison Between 1.5 and 3 Tesla

Thieme

Dietrich

Maxien

et al. 2011

Fortschr Röntgenstr

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“…It can evaluate COPD as well as pulmonary function testing and quantitatively assessed thin-section CT. as useful procedures for assessing regional morphological and functional changes (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31). It has been reported that oxygenenhanced MRI could be used for the detection of regional ventilation and alveolocapillary gas transfer (25)(26)(27)(28)(29)(30)(31). However, the literature shows no publications dealing with prospective and direct comparison of the capability of quantitatively assessed thin-section CT using the density-masked CT technique (quantitative CT) and of O 2 -enhanced MRI for smokingrelated functional loss assessment and clinical stage classification of smoking-related COPD in a large prospective cohort, such as multicenter trials in various countries.…”

Section: What This Study Adds To the Fieldmentioning

confidence: 99%

Oxygen-enhanced Magnetic Resonance Imaging versus Computed Tomography

Ohno¹,

Iwasawa²,

Seo³

et al. 2008

Am J Respir Crit Care Med

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“…A possibility which is proposed in several projects, including work from our group, calculates T1 maps based on measurements from snapshot FLASH sequences [10, 26, 27]. These are based on the TOMROP sequence and consist of two elements: first, magnetization is inverted using a nonselective inversion pulse, then the return to original magnetization state occurs over longitudinal relaxation and an image is created using a series of measurements taken from a fast snapshot FLASH sequence [28].…”

Section: Techniquementioning

confidence: 99%

Quantitative and O₂ Enhanced MRI of the Pathologic Lung: Findings in Emphysema, Fibrosis, and Cystic Fibrosis

Stadler

Stiebellehner

Jakob

et al. 2007

International Journal of Biomedical Imaging

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Purpose: beyond the pure morphological visual representation, MR imaging offers the possibility to quantify parameters in the healthy, as well as, in pathologic lung parenchyma. Gas exchange is the primary function of the lung and the transport of oxygen plays a key role in pulmonary physiology and pathophysiology. The purpose of this review is to present a short overview of the relaxation mechanisms of the lung and the current technical concepts of T1 mapping and methods of oxygen enhanced MR imaging. Material and Methods: molecular oxygen has weak paramagnetic properties so that an increase in oxygen concentration results in shortening of the T1 relaxation time and thus to an increase of the signal intensity in T1 weighted images. A possible way to gain deeper insights into the relaxation mechanisms of the lung is the calculation of parameter Maps. T1 Maps based on a snapshot FLASH sequence obtained during the inhalation of various oxygen concentrations provide data for the creation of the so-called oxygen transfer function (OTF), assigning a measurement for local oxygen transfer. T1 weighted single shot TSE sequences also permit expression of the signal changing effects associated with the inhalation of pure oxygen. Results: the average of the mean T1 values over the entire lung in inspiration amounts to 1199 +/− 117 milliseconds, the average of the mean T1 values in expiration was 1333 +/− 167 milliseconds. T1 Maps of patients with emphysema and lung fibrosis show fundamentally different behavior patterns. Oxygen enhanced MRT is able to demonstrate reduced diffusion capacity and diminished oxygen transport in patients with emphysema and cystic fibrosis. Discussion: results published in literature indicate that T1 mapping and oxygen enhanced MR imaging are promising new methods in functional imaging of the lung and when evaluated in conjunction with the pure morphological images can provide additional valuable information.

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Optimization and evaluation of the signal intensity change in multisection oxygen-enhanced MR lung imaging

Cited by 96 publications

References 17 publications

Oxygen-Enhanced MRI of the Lungs: Intraindividual Comparison Between 1.5 and 3 Tesla

Oxygen-Enhanced MRI of the Lungs: Intraindividual Comparison Between 1.5 and 3 Tesla

Oxygen-enhanced Magnetic Resonance Imaging versus Computed Tomography

Quantitative and O₂ Enhanced MRI of the Pathologic Lung: Findings in Emphysema, Fibrosis, and Cystic Fibrosis

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Optimization and evaluation of the signal intensity change in multisection oxygen-enhanced MR lung imaging

Cited by 96 publications

References 17 publications

Oxygen-Enhanced MRI of the Lungs: Intraindividual Comparison Between 1.5 and 3 Tesla

Oxygen-Enhanced MRI of the Lungs: Intraindividual Comparison Between 1.5 and 3 Tesla

Oxygen-enhanced Magnetic Resonance Imaging versus Computed Tomography

Quantitative and O2 Enhanced MRI of the Pathologic Lung: Findings in Emphysema, Fibrosis, and Cystic Fibrosis

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Quantitative and O₂ Enhanced MRI of the Pathologic Lung: Findings in Emphysema, Fibrosis, and Cystic Fibrosis