Optimization of complex therapy of inflammatory diseases of women pelvic organs

Abstract

Inflammatory diseases of women pelvic organs in reproductive period reach 60% among outpatients and 30% among inpatient gynecological patients. Aim. The aim of the study was to evaluate therapy effectiveness of women pelvic organs deseases with Galavit as part of combination therapy compared to standard treatment. Materials and methods. The study included 120 patients with diagnosis of inflammatory diseases of pelvic organs, randomized to 2 equal groups (n=60). In the main group, the patient in complex therapy received Galavit, according to the scheme: for 5 days, 100 mg intramuscularly 1 time per day, then 100 mg every 72 hours (No. 20); in the control group - only standard treatment. Results. Improvement of clinical condition (reduction of severity, normalization of body temperature, reduction of pain syndrome) in patients of the main group was observed 2 times faster than in patient of control group. Quickly resolve the signs of inflammation by ultrasound in the main group. The number of leukocytes, ESR, LII in the main group normalized faster than in patient of control group. On the background of treatment complications of inflammatory diseases of women pelvic organs was observed in 6 (5%) patients of the main group and 9 (7.5%) patients of the control group; aftercare of patients of the main group with ineffectiveness of therapy was achieved without tubectomy. The duration of treatment in the study group was 8±2.6 days us 10±3.9 days in the control group. Conclusion. The inclusion of Galavit in the complex therapy of inflammatory diseases of women pelvic organs accelerates relief of inflammation symptoms and reduces frequency of complications, which allows to preserve reproductive function. Galavit can be recommended for treatment inflammatory diseases of women pelvic organs.

Diagnostically significant changes in subsets CD11b⁺CD64^-CD32⁺CD16⁺, CD11b⁺CD64⁺CD32⁺CD16⁺ neutrophilic granulocytes of immunocompromised women with chronic infectious and inflammatory diseases of the genital tract of various etiologies

“…Chronic inflammatory diseases of the pelvic organs (pelvic inflammatory disease, PID) are one of the main problems among gynecological diseases due to their wide distribution, and they can be represented both as separate nosological forms and in various combinations. Despite the improvement of methods of diagnosis and treatment according to the World Health Organization (WHO), 448 million new cases of сhronic inflammatory diseases of the pelvic organs are registered annually in the world (up to 60% of the total number of gynecological diseases) [10,12]. According to modern scientific data, the etiology of chronic PID is polymicrobial, associated not only with obligate pathogens (Neisseria gonorrhoeae, Chlamydia trachomatis, etc.…”