2014
DOI: 10.1016/j.cropro.2014.07.020
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Optimization of cultivation medium for enhanced production of antifungal metabolites by Streptomyces hygroscopicus

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Cited by 38 publications
(25 citation statements)
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“…The source and concentration of nutrients along with the cultural conditions are known to have mysterious effects on bioactive metabolite production in Streptomyces too, since the antibiotic production is not a static property [7]. Therefore, designing an appropriate medium and conditions for cultivation has prime importance in improving the antibiotic yield [8].…”
Section: Introductionmentioning
confidence: 99%
“…The source and concentration of nutrients along with the cultural conditions are known to have mysterious effects on bioactive metabolite production in Streptomyces too, since the antibiotic production is not a static property [7]. Therefore, designing an appropriate medium and conditions for cultivation has prime importance in improving the antibiotic yield [8].…”
Section: Introductionmentioning
confidence: 99%
“…Response surface methodology has several advantages that include less trials, suitability for multiple factor experiments, determination of relativity between factors, defining the most suitable conditions, and forecast responses. The method is widely used in optimization of microbial fermentation processes (Chang et al 2006;Wang et al 2008Wang et al , 2010aWang et al 2011;Grahovac et al 2014;Kong et al 2014).…”
Section: Introductionmentioning
confidence: 99%
“…The supernatants of the five media used to cultivate the FA13 strain could all efficiently suppress the production of norsolorinic acid, indicating that the FA13 strain could grow on a broad range of nutrient substances and produce active metabolites that inhibit the mycelial growth of A. parasiticus and production of aflatoxin. In order to enhance the yield of anti-fungal substances, many researchers used response surface methodology to optimize cultivation media and cultivation conditions [20][21][22]. Uniform design was first proposed by Wang yuan and Fang kaitai in 1978 [23].…”
Section: Discussionmentioning
confidence: 99%