Optimization of succinic acid production from cane molasses by Actinobacillus succinogenes GXAS137 using response surface methodology (RSM)

Shen, Naikun; Wang, Qingyan; Qin, Yan; Zhu, Jin; Zhu, Qixi; Mi, Huizhi; Wei, Yutuo; Huang, Ribo

doi:10.1007/s10068-014-0261-7

Cited by 27 publications

(15 citation statements)

References 26 publications

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“…CCTCC M 2011399). This strain produces high amount of SA (Shen et al, 2014(Shen et al, , 2015. Cells were grown in 100 mL sealed anaerobic bottles containing 50 mL of medium.…”

Section: Microorganism and Growth Conditionsmentioning

confidence: 99%

Succinic acid production from duckweed (Landoltia punctata) hydrolysate by batch fermentation of Actinobacillus succinogenes GXAS137

Shen

Wang

Zhu

et al. 2016

Bioresource Technology

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“…CCTCC M 2011399). This strain produces high amount of SA (Shen et al, 2014(Shen et al, , 2015. Cells were grown in 100 mL sealed anaerobic bottles containing 50 mL of medium.…”

Section: Microorganism and Growth Conditionsmentioning

confidence: 99%

Succinic acid production from duckweed (Landoltia punctata) hydrolysate by batch fermentation of Actinobacillus succinogenes GXAS137

Shen

Wang

Zhu

et al. 2016

Bioresource Technology

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“…When sugar cane molasses was treated with sulfuric acid, 55.2 g L −1 of succinic acid with productivity of 1.15 g L −1 h −1 was obtained in fed‐batch cultures by A. succinogenes CGMCC1593 . The total sugars concentration of cane molasses was investigated and under the optimized medium (85 g L −1 of total sugars of cane molasses, 8.8 g L −1 of yeast extract, 63.1 g L −1 of MgCO 3 ) 64.3 g L −1 of succinic acid could be obtained after 60 h, using response surface methodology . Jiang et al .…”

Section: Optimization Of Fermentation Conditions To Improve Succinic mentioning

confidence: 99%

Bio‐based succinic acid: an overview of strain development, substrate utilization, and downstream purification

Dai

Guo

Zhang

et al. 2019

Biofuels Bioprod Bioref

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Succinic acid is an industrially important platform chemical that could be used as precursor for the establishment of a sustainable chemical industry. Due to the depletion of crude oil and the need for sustainable development, the biological production of succinic acid from renewable resources has attracted wide attention. To establish an economical bio‐based succinic acid production process, various metabolic engineering strategies have been developed and applied to improve the strain performance, including efficient CO2 fixation, by‐product elimination, use of metabolic modeling approaches, engineering of transcriptional regulations and optimization of reducing power balance. The utilization of renewable waste resources and the optimization of purification process have also been investigated to decrease the cost. This review will provide insights for current advances in succinic acid production and perspectives on further research to make bio‐based succinic acid production more efficient and economical. © 2019 Society of Chemical Industry and John Wiley & Sons, Ltd

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“…CCTCC M 2011399). This strain was shown to produce high amount of SA (Shen et al 2014). Cells were grown in 100 ml sealed anaerobic bottles containing 50 ml of medium.…”

Section: Micro-organism and Growth Conditionsmentioning

confidence: 99%

Production of succinic acid from sugarcane molasses supplemented with a mixture of corn steep liquor powder and peanut meal as nitrogen sources by Actinobacillus succinogenes

Shen

Qin

Wang

et al. 2015

Lett Appl Microbiol

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The potential of using corn steep liquor powder (CSLP), peanut meal (PM), soybean meal (SM), cotton meal (CM) and urea as the substitute of yeast extract (YE) as the nitrogen source was investigated for producing succinic acid (SA). Actinobacillus succinogenes GXAS137 was used as the fermenting bacterium and sugarcane molasses was used as the main substrate. None of these materials were able to produce SA as high as YE did. The CSLP could still be considered as a feasible and inexpensive alternate for YE as the yield of SA produced using CSLP was second only to the yield of SA obtained by YE. The use of CSLP-PM mixed formulation (CSLP to PM ratio = 2·6) as nitrogen source produced SA up to 59·2 g l(-1) with a productivity of 1·2 g l(-1) h(-1). A batch fermentation using a stirred bioreactor produced up to 60·7 g l(-1) of SA at the same formulation. Fed-batch fermentation that minimized the substrate inhibition produced 64·7 g l(-1) SA. These results suggest that sugarcane molasses supplemented with a mixture of CSLP and PM as the nitrogen source could be used to produce SA more economically using A. succinogenes. Significance and impact of the study: Succinic acid (SA) is commonly used as a platform chemical to produce a number of high value derivatives. Yeast extract (YE) is used as a nitrogen source to produce SA. The high cost of YE is currently the limiting factor for industrial production of SA. This study reports the use of a mixture of corn steep liquor powder (CSLP) and peanut meal (PM) as an inexpensive nitrogen source to substitute YE. The results showed that this CSLP-PM mixed formulation can be used as an effective and economic nitrogen source for the production of SA.

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Optimization of succinic acid production from cane molasses by Actinobacillus succinogenes GXAS137 using response surface methodology (RSM)

Cited by 27 publications

References 26 publications

Succinic acid production from duckweed (Landoltia punctata) hydrolysate by batch fermentation of Actinobacillus succinogenes GXAS137

Succinic acid production from duckweed (Landoltia punctata) hydrolysate by batch fermentation of Actinobacillus succinogenes GXAS137

Bio‐based succinic acid: an overview of strain development, substrate utilization, and downstream purification

Production of succinic acid from sugarcane molasses supplemented with a mixture of corn steep liquor powder and peanut meal as nitrogen sources by Actinobacillus succinogenes

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