The article presents the results of a field vegetation experiment in the Rostov region on the cultivation of spring wheat of the “Zlata” variety with the use of an environmentally oriented organic mineral fertilizer from liquid waste of pig farms by the method of split plots with a randomized placement of variants in repetitions, the repetition of the experiment is three-fold. The agrochemical indicators of the soil before and after wheat cultivation at the horizons of 0-20 and 20-40 cm are given. The scheme of carrying out the experiment, including different doses of organic mineral fertilizer application and a plan for cutting plots, is indicated. During the growing season, constant observations of the plants were carried out together with the care. The dynamics of the growth of wheat biomass in different periods of time from planting and its yield are presented. The influence of different doses of ecologically oriented organic mineral fertilizer from pig manure on the yield of spring wheat is estimated. According to the results of experimental data, the effective dose of organic mineral fertilizer application from pig manure was established-2t/ha. The yield of grain crops (wheat) per hectare was determined-49.2 c / ha. The spring wheat variety “Zlata”, which is unusual for the Rostov region, gave a high yield when applying an environmentally oriented fertilizer, which proves its value both in agronomic and ecological terms. The absence of toxic effects on the soil of organic mineral fertilizers for heavy metals (copper, nickel. cadmium, lead), an increase in humus from 5.43% to 5.52%. The assessment of the nutrient reserves in seeds and the effect of organic mineral fertilizer doses on the quality of spring wheat grain of the «Zlata» variety is given. The highest amount of gluten-40.03% - was observed when using the fertilizer at a dose of 2 t / ha.