“…Over the last few decades, scientists have investigated some biowastes, such as bovine bones, fish bones, avian eggshells, cuttlefish shells, oyster shells, and corals to develop calcium phosphates (CaPs) for biomedical applications [ 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 ] as they exhibit several advantages over synthetically developed materials in terms of biocompatibility, biodegradability, and remodelling [ 56 , 57 ]. For example, Kim et al [ 57 ] prepared HA granules from cuttlefish bone (CB) via the hydrothermal method, and they reported that the CB-HA showed non-cytotoxicity, enhanced cell adhesion, proliferation, and differentiation (confirmed via in vitro and in vivo bioactivity tests), and higher bone growth during in vivo bone defect healing experiments.…”