Optimizing Hemostatic Practices: Matching the Appropriate Hemostat to the Clinical Situation

Neveleff, Deborah J.

doi:10.1016/j.aorn.2012.08.005

Cited by 27 publications

(33 citation statements)

References 29 publications

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“…Efforts to address bleeding‐associated consequences align well with AORN's value of promoting cutting‐edge innovations to enhance safety and optimal outcomes for surgical patients 17 . Given the role that perioperative nurses play in influencing hemostatic practices in the OR, they make excellent agents for championing initiatives that reduce complications and decrease costs related to intraoperative bleeding 18 …”

Section: Recent Initiatives and A Call To Actionmentioning

confidence: 99%

Viscoelastic Studies: Effective Tools for Trauma and Surgical Resuscitation Efforts

Salinas¹

2017

AORN Journal

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Trauma-induced coagulopathy (TIC) is an abrupt disruption of all hemostatic components of coagulation resulting from severe tissue injury and hypoperfusion. The effective management of TIC has remained elusive to clinicians using traditional laboratory methods, challenging efforts to improve outcomes related to uncontrolled bleeding. Recent initiatives have aimed to reduce TIC-associated morbidity and mortality, further invoking trauma experts to explore innovative modalities in the field of viscoelastic studies, such as thromboelastography (TEG) and rotational thromboelastometry (ROTEM). These tests are able to guide proper blood product administration more effectively during trauma and surgical resuscitation compared with conventional laboratory tests. Although TEG and ROTEM are similar tests, inherent differences in their features produce variation in output results. This article calls on the perioperative clinician to evaluate TEG and ROTEM tests and consider their implementation based on the benefits of their application to clinical practice.

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Section: Recent Initiatives and A Call To Actionmentioning

confidence: 99%

Viscoelastic Studies: Effective Tools for Trauma and Surgical Resuscitation Efforts

Salinas¹

2017

AORN Journal

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“…For example, thrombin‐based hemostats were widely used to facilitate clot formation as hemostatic agents. However, it has a short shelf life in the liquid form without repeated use, and thrombin products can cause immune and allergic responses and transmission of infectious diseases . Therefore, there is a need to develop a safe and effective active hemostatic agent.…”

Section: Introductionmentioning

confidence: 99%

“…Hemostatic agent is one of the most crucial tools during surgery because surgical bleeding can increase the physical and economic burden of the patient and can even seriously threaten the life of the patient. [1] Surgical bleeding makes it challenging to obtain a visual field for the surgical site and prolongs the operation time. Therefore, relatively quick and easy mechanical hemostats such as suture, clips, gelatin patch, collagen patch, and electrosurgery are widely used.…”

Section: Introductionmentioning

confidence: 99%

“…However, it has a short shelf life in the liquid form without repeated use, [4] and thrombin products can cause immune and allergic responses and transmission of infectious diseases. [1] Therefore, there is a need to develop a safe and effective active hemostatic agent. After the human genome sequence was fully known, many studies have been revealing the structure and function of proteins or peptides.…”

Section: Introductionmentioning

confidence: 99%

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Newly Identified HNP‐F from Human Neutrophil Peptide‐1 Promotes Hemostasis

Kim

Lee

et al. 2019

Biotechnology Journal

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Active hemostatic agents can play a crucial role in saving patients’ lives during surgery. Active hemostats have several advantages including utilization of natural blood coagulation and biocompatibility. Among them, although human neutrophil peptide‐1 (HNP‐1) has been previously reported with the hemostatic mechanism, which part of HNP‐1 facilitates the hemostatic activity is not known. Here, a partial peptide (HNP‐F) promoting hemostasis, originating from HNP‐1, has been newly identified by the blood coagulation ability test. HNP‐F shows the best hemostatic effect between the anterior half and posterior half of peptides. Moreover, microscopic images show platelet aggregation and an increase in the concentration of platelet factor 4, and the scanning electron microscope image of platelets support platelet activation by HNP‐F. Thromboelastography indicates decreased clotting time and increased physical properties of blood clotting. Mouse liver experiments demonstrate improved hemostatic effect by treatment of peptide solution. Cell viability and hemolysis assays confirm the HNP‐F's biosafety. It is hypothesized that the surface charge and structure of HNP‐F could be favorable to interact with fibrinogen or thrombospondin‐1. Collectively, because HNP‐F as an active peptide hemostat has many advantages, it could be expected to become a potent hemostatic biomaterial, additive or pharmaceutical candidate for various hemostatic applications.

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“…Methods to staunch bleeding include applying pressure, suturing, using thermal-based energy devices, or using hemostatic agents8. A large variety of hemostatic products have been developed and marketed in the last few decades, including gelatin, collagen, oxidized regenerated cellulose, polysaccharide spheres, thrombin, fibrin sealant, zeolite, chitosan, starch-related products and so on291011.…”

mentioning

confidence: 99%

Haem-assisted dityrosine-cross-linking of fibrinogen under non-thermal plasma exposure: one important mechanism of facilitated blood coagulation

Huang

2016

Sci Rep

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Although blood coagulation facilitated by non-thermal plasma has been reported several years ago, the insight to the involved mechanisms is still rather limited. In this work, we report our discovery of a new mechanism for the haem-promoted blood-coagulation caused by non-thermal plasma treatment. The reason for the haem role is due to that its oxidized form, namely, hematin, can promote the dityrosine cross-linking of fibrinogen, the most important coagulation protein, to form a membrane-like layer on the surface of the treated blood with plasma exposure. Both haem and non-thermal-plasma generated hydrogen peroxide are requisite for the cross-linking process. We confirmed that fibrinogen can coordinate with the haem iron to form a protein-haem complex which shows pseudo-peroxidase activity, and in the presence of hydrogen peroxide, the complex can induce the dityrosine formation between fibrinogen molecules, leading to the fibrin network necessary for the blood coagulation. Understanding of such an underlying mechanism can be useful to guide more efficient application of non-thermal plasma in the management of hemostasis, thrombosis and etc.

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Optimizing Hemostatic Practices: Matching the Appropriate Hemostat to the Clinical Situation

Cited by 27 publications

References 29 publications

Viscoelastic Studies: Effective Tools for Trauma and Surgical Resuscitation Efforts

Viscoelastic Studies: Effective Tools for Trauma and Surgical Resuscitation Efforts

Newly Identified HNP‐F from Human Neutrophil Peptide‐1 Promotes Hemostasis

Haem-assisted dityrosine-cross-linking of fibrinogen under non-thermal plasma exposure: one important mechanism of facilitated blood coagulation

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