Universities within the era of the 4.0 industrial revolution, now must immediately improve in preparing themselves, especially related to human resources. Lecturers as a determining factor in the progress of education, are always required to upgrade their skills and abilities. In Indonesia, the majority of lecturers are dominated by baby boomers and generation X or digital immigrants who, in some cases, experience obstacles. In the present reality that students are now a millennial or digital native generation who tend to have their learning styles and patterns. This article highlights the competencies that must be mastered by lecturers in the current industrial revolution 4.0 era, namely: (i) educational competence, (ii) competence in research, (iii) competence of technological commercialization, (iv) competence in future strategies, (v) competence counsellor, (vi) competence in globalization, and vii) joint competence.