Oral administration of a casein matrix containing β-casofensin protects the intestinal barrier in two preclinical models of gut diseases

Bessette, Claudine; Henry, Gwénaële; Sekkal, Soraya; Benoit, Bérengère; Bruno, Jérémie; Meugnier, Emmanuelle; Ferrier, Laurent; Théodorou, Vassilia; Léonil, Joëlle; Plaisancié, Pascale

doi:10.1016/j.jff.2016.09.007

Cited by 13 publications

(10 citation statements)

References 29 publications

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“…Reduction of Paneth and goblet cells was shown to increase sensitivity of mice to TNF‐induced toxicity, accompanied by increased hypothermia, lethality and intestinal permeability (Van Hauwermeiren et al, ). Decrease of these cells was induced by different stress conditions, such as neonatal maternal separation (Bessette et al, ), chronic and heat stress (Deng et al, ; Gao et al, ). Our results revealed that pretreatment of rats with S. cerevisiae fermentate before exposure to heat stress prevented decline of Paneth and goblet cells.…”

Section: Discussionmentioning

confidence: 99%

Yeast fermentate prebiotic improves intestinal barrier integrity during heat stress by modulation of the gut microbiota in rats

et al. 2019

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Aims To evaluate efficacy of Saccharomyces cerevisiae fermentate prebiotic (EH) in protection of intestinal barrier integrity in rats during heat stress, to analyze the impact of heat stress and preventive treatment with EH on the structure of the gut microbiota. Methods and Results Two groups of rats were treated orally with EH or phosphate‐buffered saline for 14 days. On day 15, half of the rats in each group were exposed to heat stress conditions, while control animals were kept at room temperature. Histological and Western blot analyses of the intestine, culture‐based microbiological analysis and high‐throughput 16S rRNA sequencing for the gut microbiota were performed for each rat. Exposure of animals to heat stress conditions resulted in inhibition of tight junction (TJ) proteins expression, decrease of Paneth and goblet cells, decrease of beneficial and increase of pathogenic bacteria. Oral treatment of rats with EH before stress significantly prevents these adverse effects by elevation of the gut beneficial bacteria, particularly butyrate‐producing bacteria. Conclusions Essential effect of EH in protection of intestinal barrier integrity during heat stress is connected with beneficial modulation of the gut microbiota. Significance and Impact of the Study Our results will contribute to the development of new approaches to prevention of heat stress‐related complications.

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Section: Discussionmentioning

confidence: 99%

Yeast fermentate prebiotic improves intestinal barrier integrity during heat stress by modulation of the gut microbiota in rats

et al. 2019

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“…[93] Later on, a bioactive -casein f(94-123) peptide, termed as -casofensin, was found to protect against intestinal epithelial injury induced by both the drug indomethacin and neonatal maternal separation, improving the mucosal barrier status of treated rats. [94,95] In addition, the anti-inflammatory properties of caseinomacropeptide have been confirmed in some animal models of intestinal inflammation. [82] The short-term intake of soybean (2 g kg −1 body weight, daily during 7 days) has been found to increase the total antioxidant activity of healthy men and women, and diminish the advanced oxidation protein products in the female group.…”

Section: Oxidative Damage and Inflammationmentioning

confidence: 94%

“…[ 93 ] Later on, a bioactive β‐casein f(94‐123) peptide, termed as β‐casofensin, was found to protect against intestinal epithelial injury induced by both the drug indomethacin and neonatal maternal separation, improving the mucosal barrier status of treated rats. [ 94,95 ] In addition, the anti‐inflammatory properties of caseinomacropeptide have been confirmed in some animal models of intestinal inflammation. [ 82 ]…”

Section: Bioactivity Of Peptides Over Digestive Healthmentioning

confidence: 99%

Gastrointestinal Digestion of Food Proteins under the Effects of Released Bioactive Peptides on Digestive Health

Fernández-Tomé

Hernández-Ledesma

2020

Molecular Nutrition Food Res

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The gastrointestinal tract represents a specialized interface between the organism and the external environment. Because of its direct contact with lumen substances, the modulation of digestive functions by dietary substances is supported by a growing body of evidence. Food-derived bioactive peptides have demonstrated a plethora of activities in the organism with increasing interest toward their impact over the digestive system and related physiological effects. This review updates the biological effects of food proteins, specifically milk and soybean proteins, associated to gastrointestinal health and highlights the study of digestion products and released peptides, the identification of the active form/s, and the evaluation of the mechanisms of action underlying their relationship with the digestive cells and receptors. The approach toward the modifications that food proteins and peptides undergo during gastrointestinal digestion and their bioavailability is a crucial step for current investigations on the field. The recent literature on the regulation of digestive functions by peptides has been mostly considered in terms of their influence on gastrointestinal motility and signaling, oxidative damage and inflammation, and malignant cellular proliferation. A final section regarding the actual challenges and future perspectives in this scientific topic is critically discussed.

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“…Numbers of BAPs derived from various food proteins (milk, plant, egg, soybean, meat, wheat, rice, potato, corn silk, fish, etc.) have been found to be well suited to treat inflammation or IBD symptoms in vivo ( Table 2 ), such as Ala-Gln (AQ) [ 9 , 52 – 54 ], DIKTNKPVIF [ 45 ], EWP [ 55 ], GLTSK [ 56 ], glycomacropeptide [ 57 – 60 ], lunasin [ 15 ], IRW [ 11 , 61 – 63 ], IQW [ 62 – 64 ], KGHYAERVG [ 65 ], KPV [ 66 ], PTGADY [ 67 ], QCQCAVEGGL [ 68 ], QEPVL, QEPV [ 6 ], RILSILRHQNLLKELQDLAL [ 69 ], SSEDIKE [ 70 ], TMKLLLVTL [ 43 ], VPP [ 31 , 46 , 71 , 72 ], IPP [ 71 , 72 ], VPY [ 33 ], WH [ 41 ], casein hydrolysates [ 73 ], soybean dipeptides and tripeptides [ 74 ], peptide P-317 [ 75 ], pyroGlu-Leu [ 76 ], β -Casofensin [ 77 ], γ -EC, and γ -EV [ 47 ]. These studies suggest that oral administration of food-derived BAPs have anti-inflammatory effects, and they can be the therapeutic agents for inflammatory-related diseases, including IBD [ 78 ].…”

Section: The In Vivo Studies Of Baps On Inflammmentioning

confidence: 99%

“…Soybean-derived dipeptides and tripeptides decreased the colonic expressions of proinflammatory IFNG, IL-1B, IL-12B, TNF, and IL-17A and MPO activity and increased Foxp3 expression and CD4 + CD25 + T cells; therefore, the colon and ileum inflammation of piglets with DSS-induced colitis was attenuated [ 74 ]. In addition, with the infusion of 150 mg/kg of egg white protein-derived EWP, weight loss, crypt distortion, IL-6 and TNF- α concentrations, and expressions of IL-1 β , IL-8, IL-17, and IFN- γ in the colon of piglets with DSS-induced colitis can be reduced, and gut barrier function was restored [ 55 ], as well as the barrier protection effects of milk-derived β -Casofensin [ 77 ] and dipeptide AQ [ 53 ]. Therefore, food-derived BAPs can contribute to disease treatment through modifying intestinal barrier function [ 79 ].…”

Section: The In Vivo Studies Of Baps On Inflammmentioning

confidence: 99%

The Potential of Food Protein-Derived Bioactive Peptides against Chronic Intestinal Inflammation

Zhu

Ren

Zhang

et al. 2020

Mediators of Inflammation

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Inflammation can cause various chronic diseases like inflammatory bowel diseases. Various food protein-derived bioactive peptides (BAPs) with anti-inflammatory activity have the potential to manage these diseases. The aim of this paper is to overview the mechanisms and the molecular targets of BAPs to exert anti-inflammatory activity. In this review, the in vitro and in vivo effects of BAPs on intestinal inflammation are highlighted. The mechanism, pathways, and future perspectives of BAPs as the potential sources of therapeutic treatments to alleviate intestinal inflammation are provided, including nuclear factor-κB, mitogen-activated protein kinase, Janus kinase-signal transducer and activator of transcription, and peptide transporter 1 (PepT1), finding that PepT1 and gut microbiota are the promising targets for BAPs to alleviate the intestinal inflammation. This review provides a comprehensive understanding of the role of dietary BAPs in attenuating inflammation and gives a novel direction in nutraceuticals for people or animals with intestinal inflammation.

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Oral administration of a casein matrix containing β-casofensin protects the intestinal barrier in two preclinical models of gut diseases

Cited by 13 publications

References 29 publications

Yeast fermentate prebiotic improves intestinal barrier integrity during heat stress by modulation of the gut microbiota in rats

Yeast fermentate prebiotic improves intestinal barrier integrity during heat stress by modulation of the gut microbiota in rats

Gastrointestinal Digestion of Food Proteins under the Effects of Released Bioactive Peptides on Digestive Health

The Potential of Food Protein-Derived Bioactive Peptides against Chronic Intestinal Inflammation

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