Oral administration of bovine lactoferrin upregulates neutrophil functions in a dog with familial β2-integrin-related neutrophil dysfunction

Kobayashi, Saori; Abe, Yuya; Inanami, Osamu; Oda, Satoshi; Yamauchi, Koji; Hankanga, Careen; Yasuda, Jun; Sato, Ryo

doi:10.1016/j.vetimm.2011.05.027

Cited by 9 publications

(7 citation statements)

References 26 publications

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“…Concurrently, the markers of inflammation in hematological examination were gradually decreased on the male dog in this study after treatment with lactoferrin. Judging from these findings and our previous study [13], oral administration with bovine lactoferrin for a long duration seems to bring the improvement of the clinical features such as severe rhinotracheitis, ophthalmia and pneumonia by increasing the neutrophil functions of these dogs. Further studies are required, but it suggests that oral administration of bovine lactoferrin may have a potential as one of treatment options for neutrophil dysfunction without unexpected secondary effects.…”

supporting

confidence: 63%

“…The patients of LAD and CLAD are always treated by long-term administration of antibiotics for recurrent bacterial infection and other symptomatic treatment, however, would not obtain complete improvement. Two canine littermates with neutrophil dysfunction showed that their neutrophil functions were upregulated by administration of bovine lactoferrin in a previous study [13]. This study reported detailed clinical effects of oral administration of bovine lactoferrin on the same littermates with neutrophil dysfunction and an investigation of their genetic background.…”

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confidence: 66%

“…The female and male dogs were treated with bovine lactoferrin internally (Morinaga Milk Industry Company., Tokyo, Japan, 40 mg/kg, sid) in combination with the other symptomatic therapy including antibiotics therapy for a month and 140 days, respectively. Oral treatment with bovine lactoferrin increased the neutrophil functions [13], followed by improvement of the clinical signs and hematologi- Pretreatment: at the first medical examination in our hospital. ND: Not determined.…”

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confidence: 94%

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Clinical Effects of Bovine Lactoferrin on Two Canine Cases with Familial Neutrophil Dysfunction

Sato

Kobayashi

Abe

et al. 2012

The Journal of Veterinary Medical Science

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ABSTRACT. This study reported detailed clinical effects of bovine lactoferrin on 2 canine littermates (1 female and 1 male) with familial neutrophil dysfunction and an investigation of their genetic background. Clinical signs caused by severe upper respiratory bacterial infections were observed in these dogs. Oral administration of bovine lactoferrin for a long duration improved their clinical signs (severe uveitis in the female dog and coughing from pneumonia in the male dog). Their backcross dogs that have the same father didn't show clinical signs of bacterial infection. Neutrophil function tests revealed that the backcross dogs didn't have any disorders. It is likely that abnormal clinical signs are associated with neutrophil dysfunction in the colony, and the mother dog of these cases might be the genetic carrier of this dysfunction. KEY WORDS: bovine lactoferrin, familial canine neutrophil dysfunction, genetic background.

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confidence: 63%

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confidence: 66%

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confidence: 94%

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Clinical Effects of Bovine Lactoferrin on Two Canine Cases with Familial Neutrophil Dysfunction

Sato

Kobayashi

Abe

et al. 2012

The Journal of Veterinary Medical Science

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“…A study in dogs 36 found that oral treatment with bovine LF increased neutrophil β2‐integrin transcript levels, in turn leading to the upregulation of neutrophil functions. Moreover, a study performed in mice 37 found that LF supplementation reduced TNF‐α and increased IL‐10. LF inhibited adipocyte differentiation in C3T3‐G2/PA6 and 3T3‐L1 cell lines, respectively 38, 39.…”

Section: Addressing the Problem With Dietary Preventative Methodsmentioning

confidence: 99%

Role of dietary proteins and peptides in cardiovascular disease

Cam

Mejía

2011

Molecular Nutrition Food Res

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Cardiovascular disease (CVD) is the leading cause of death for both men and women in the United States and most other countries. Therefore, a disease of such wide-ranging impact calls for the development of multiple viable strategies for prevention. Diet plays an important role in the development of the major risk factors of CVD such as low-grade systemic inflammation, hypertension, obesity, diabetes and atherosclerosis, the most significant. Thus, diet-based methods of prevention would not only be more feasible, but ultimately more cost-effective than relying on drugs to combat this condition. In recent years, peptides derived from either animal or plant sources have been found to have various bioactive properties. Nevertheless, their potential impact on inflammation and prevention of atherosclerosis has not been fully explored, particularly at the molecular level. In this review, the most current scientific information from in vitro, in vivo and clinical studies on the role of dietary proteins and peptides on CVD has been summarized and discussed.

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“…Lf is endowed with a plethora of biological functions, including antimicrobial, antiviral, antiparasite, anti-inflammatory, and anticancer activities ( 12 ). Lf-binding proteins have been detected on the surfaces of various cells, including neutrophils, monocytes, and peritoneal macrophages ( 13 , 14 ), as well as on the surfaces of various microorganisms ( 15 ). Lf is an important pro-resolving mediator when it is released from apoptotic neutrophils, i.e ., it blocks the directed migration of neutrophils and eosinophils ( 16 , 17 ).…”

Section: Introductionmentioning

confidence: 99%

A 17-kDa Fragment of Lactoferrin Associates With the Termination of Inflammation and Peptides Within Promote Resolution

et al. 2018

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During the resolution of inflammation, macrophages engulf apoptotic polymorphonuclear cells (PMN) and can accumulate large numbers of their corpses. Here, we report that resolution phase macrophages acquire the neutrophil-derived glycoprotein lactoferrin (Lf) and fragments thereof in vivo and ex vivo. During the onset and resolving phases of inflammation in murine peritonitis and bovine mastitis, Lf fragments of 15 and 17 kDa occurred in various body fluids, and the murine fragmentation, accumulation, and release were mediated initially by neutrophils and later by efferocytic macrophages. The 17-kDa fragment contained two bioactive tripeptides, FKD and FKE that promoted resolution phase macrophage conversion to a pro-resolving phenotype. This resulted in a reduction in peritoneal macrophage numbers and an increase in the CD11blow subset of these cells. Moreover, FKE, but not FKD, peptides enhanced efferocytosis of apoptotic PMN, reduced TNFα and interleukin (IL)-6, and increased IL-10 secretion by lipopolysaccharide-stimulated macrophages ex vivo. In addition, FKE promoted neutrophil-mediated resolution at high concentrations (100 µM) by enhancing the formation of cytokine-scavenging aggregated NETs (tophi) at a low cellular density. Thus, PMN Lf is processed, acquired, and “recycled” by neutrophils and macrophages during inflammation resolution to generate fragments and peptides with paramount pro-resolving activities.

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Oral administration of bovine lactoferrin upregulates neutrophil functions in a dog with familial β2-integrin-related neutrophil dysfunction

Cited by 9 publications

References 26 publications

Clinical Effects of Bovine Lactoferrin on Two Canine Cases with Familial Neutrophil Dysfunction

Clinical Effects of Bovine Lactoferrin on Two Canine Cases with Familial Neutrophil Dysfunction

Role of dietary proteins and peptides in cardiovascular disease

A 17-kDa Fragment of Lactoferrin Associates With the Termination of Inflammation and Peptides Within Promote Resolution

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