Oral administration of cernitin pollen extract (Cernilton<sup>®</sup>) for 30 days might be useful to avoid unnecessary biopsy in prostate biopsy candidates: A preliminary study

Togo, Yoshikazu; Ichioka, Daishi; Miyazaki, Jun; Maeda, Yukihide; Kameyama, Koji; Yasuda, Mitsuru; Hiyama, Yoshiki; Takahashi, Satoshi; Nagae, Hiroshi; Hirota, Seiichi; Yamamoto, Shingo

doi:10.1111/iju.13549

Cited by 8 publications

(7 citation statements)

References 26 publications

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“…The results presented in this study revealed that Cernitin® treatment was able to significantly reduce AR and PSA levels, albeit lesser than finasteride. The decrease of PSA value is also demonstrated in a recent clinical study (Togo et al, 2018). A simultaneous decrease in cell proliferation of both cell lines was found after treatment with Cernitin®.…”

Section: Discussionsupporting

confidence: 59%

“…Numerous clinical studies have shown that Cernitin® treatment significantly reduced prostatic volume in patients presenting with BPH (Buck, Cox, Rees, Ebeling, & John, 1990;Preuss et al, 2001). Furthermore, these clinical studies confirmed the efficacy of this drug by the relief of CP/CPPS symptoms and suppression of prostate-specific antigen (PSA) (Togo et al, 2018). In addition to clinical reports, the efficacy of Cernitin® in the inhibition of proliferation and inflammation has been validated in preclinical studies (Asakawa et al, 2001;Kamijo, Sato, & Kitamura, 2001;Talpur, Echard, Bagchi, Bagchi, & Preuss, 2003).…”

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confidence: 92%

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The effects of Cernitin® on inflammatory parameters and benign prostatic hyperplasia: An in vitro study

Dizeyi

Mattisson

Ramnemark³

et al. 2019

Phytotherapy Research

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The pollen extract Cernitin® is widely used for treatment of benign prostatic hyperplasia (BPH) and non‐bacterial chronin prostatitis. However, little is known about the underlying molecular mechanisms to explain the clinical effects of Cernitin®. In this study, we sought to investigate the cellular mechanisms by which Cernitin® induces its effects on human prostatic cell lines BPH‐1 and WPMY‐1 and primary human peripheral blood mononuclear cells (hPBMCs) in vitro. We examined the effects of Cernitin® formulas T60 and GBX on the protein expression, proliferation, and cytokines production. Results revealed that Cernitin® upregulated antiinflammatory cytokine interleukin (IL)‐10 and its receptors IL‐10RA and IL‐10B in addition to the upregulation of tumour necrosis factor‐related apoptosis‐inducing ligand in hPBMC. Interestingly, the levels of proinflammatory cytokines IL‐6 and IL‐8 were also increased. Furthermore, Cernitin® had significantly increased the level of IL‐10 in BPH‐1 and WPMY‐1 cells. The level of IL‐6 was also significantly increased in these cells although both T60 and GBX inhibited STAT‐3 phosphorylation. Moreover, Cernitin® formulas had significantly reduced androgen receptor and prostate‐specific antigen protein expression in stromal cells (p < .05). Treatment with GBX and T60 had significantly inhibited proliferation of BPH (p < .001) and stromal cells (p < .05), in a dose‐dependent manner. Taken together, treatment with Cernitin® showed to regulate cytokines level in both prostatic cell lines and hPBMCs and it was associated with decreased androgen receptor and prostate‐specific antigen levels WPMY‐1 cells.

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Section: Discussionsupporting

confidence: 59%

mentioning

confidence: 92%

The effects of Cernitin® on inflammatory parameters and benign prostatic hyperplasia: An in vitro study

Dizeyi

Mattisson

Ramnemark³

et al. 2019

Phytotherapy Research

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“…In the European Association of Urology guidelines, phytotherapy, including Cernitin pollen extract (Cernilton ® ), is recommended for patients with inflammatory prostate pain syndrome, with no known reports of severe adverse events associated with its administration. If such a non-antimicrobial drug can effectively reduce serum prostate specific antigen (PSA) in prostate biopsy candidates with chronic inflammation of the prostate, an optimal method including that could be developed for avoidance of an unnecessary biopsy" [160]. Thus, to verify this possibility, Togo et al [160] administered Cernitin pollen extract tablets to prostate biopsy candidates for 30 days, before carrying out a prostate biopsy procedure.…”

Section: Chronic Prostatitismentioning

confidence: 99%

“…If such a non-antimicrobial drug can effectively reduce serum prostate specific antigen (PSA) in prostate biopsy candidates with chronic inflammation of the prostate, an optimal method including that could be developed for avoidance of an unnecessary biopsy" [160]. Thus, to verify this possibility, Togo et al [160] administered Cernitin pollen extract tablets to prostate biopsy candidates for 30 days, before carrying out a prostate biopsy procedure. Then, they evaluated the relationship between the reduction in serum PSA levels and prostate biopsy outcomes.…”

Section: Chronic Prostatitismentioning

confidence: 99%

Bee Collected Pollen and Bee Bread: Bioactive Constituents and Health Benefits

Mărgăoan

Stranț²,

Varadi³

et al. 2019

Antioxidants

119

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Bee products were historically used as a therapheutic approach and in food consumption, while more recent data include important details that could validate them as food supplements due to their bioproperties, which support their future use as medicines. In this review data, data collected from bee pollen (BP) and bee bread (BB) essays will be discussed and detailed for their nutritional and health protective properties as functional foods. Dietary antioxidants intake derived from BP and BB have been associated with the prevention and clinical treatment of multiple diseases. The beneficial effects of BP and BB on health result from the presence of multiple polyphenols which possess anti-inflammatory properties, phytosterols and fatty acids, which play anticancerogenic roles, as well as polysaccharides, which stimulate immunological activity. From the main bioactivity studies with BP and BB, in vitro studies and animal experiments, the stimulation of apoptosis and the inhibition of cell proliferation in multiple cell lines could be one of the major therapeutic adjuvant effects to be explored in reducing tumor growth. Tables summarizing the main data available in this field and information about other bio-effects of BP and BB, which support the conclusions, are provided. Additionally, a discussion about the research gaps will be presented to help further experiments that complete the tree main World Health Organization (WHO) Directives of Efficiency, Safety and Quality Control for these products.

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“…22 When comparing the beneficial effects of the two drugs on prostate inflammation, cernitin might suppress inflammation more effectively in prostate tissue than tadalafil. Togo et al 23 reported that oral administration of cernitin for 30 days significantly reduced the mean serum PSA level by 0.6 ng/mL (mean reduction of 7.6%). Meanwhile, to our knowledge, there has been no report demonstrating that tadalafil reduced the serum PSA level in patients with LUTS/BPH and/or CP/CPPS.…”

Section: Discussionmentioning

confidence: 99%

Comparison of cernitin pollen extract vs tadalafil therapy for refractory chronic prostatitis/chronic pelvic pain syndrome: A randomized, prospective study

Matsukawa

Naito

Funahashi

et al. 2020

Neurourology and Urodynamics

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Aims To compare the efficacy of cernitin pollen extract (cernitin) or tadalafil for treating persistent chronic pelvic pain despite α1‐blocker monotherapy in men with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and lower urinary tract symptoms (LUTS). Methods A total of 100 patients with refractory CP/CPPS despite ongoing α1‐blocker monotherapy were randomized to receive add‐on therapy with either cernitin (4 capsules/day) or tadalafil (5 mg/d) for 12 weeks. At week 12, changes from baseline in the patients’ CP/CPPS, LUTS, and voiding function, as assessed using the National Institutes of Health Chronic Prostatitis Symptom Index (NIH‐CPSI), the International Prostate Symptom Score (IPSS), and uroflowmetry, respectively, were compared between the groups. Results The final analysis included 42 and 45 patients in the cernitin and tadalafil groups, respectively. Although the NIH‐CPSI total, NIH‐CPSI pain sub‐score, and NIH‐CPSI quality of life sub‐score significantly improved in both groups, the cernitin (vs tadalafil) group showed significantly greater improvements in the NIH‐CPSI total score (−6.8 vs −4.6; P = .02) and NIH‐CPSI pain sub‐score (−4.1 vs −1.5; P < .001). Half (50%) of the patients in the cernitin group showed a reduction greater than 50% in their NIH‐CPSI pain sub‐score; in the tadalafil group, only four patients (8.9%) showed ≥50% improvement (P < .001). In contrast, the improvement in LUTS was significantly superior in the tadalafil group. Conclusion Both cernitin and tadalafil significantly ameliorated chronic pelvic pain in patients with refractory CP/CPPS. The add‐on of cernitin was more effective than tadalafil for pelvic pain and discomfort.

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Oral administration of cernitin pollen extract (Cernilton^®) for 30 days might be useful to avoid unnecessary biopsy in prostate biopsy candidates: A preliminary study

Cited by 8 publications

References 26 publications

The effects of Cernitin® on inflammatory parameters and benign prostatic hyperplasia: An in vitro study

The effects of Cernitin® on inflammatory parameters and benign prostatic hyperplasia: An in vitro study

Bee Collected Pollen and Bee Bread: Bioactive Constituents and Health Benefits

Comparison of cernitin pollen extract vs tadalafil therapy for refractory chronic prostatitis/chronic pelvic pain syndrome: A randomized, prospective study

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Oral administration of cernitin pollen extract (Cernilton®) for 30 days might be useful to avoid unnecessary biopsy in prostate biopsy candidates: A preliminary study

Cited by 8 publications

References 26 publications

The effects of Cernitin® on inflammatory parameters and benign prostatic hyperplasia: An in vitro study

The effects of Cernitin® on inflammatory parameters and benign prostatic hyperplasia: An in vitro study

Bee Collected Pollen and Bee Bread: Bioactive Constituents and Health Benefits

Comparison of cernitin pollen extract vs tadalafil therapy for refractory chronic prostatitis/chronic pelvic pain syndrome: A randomized, prospective study

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Product

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Oral administration of cernitin pollen extract (Cernilton^®) for 30 days might be useful to avoid unnecessary biopsy in prostate biopsy candidates: A preliminary study