Oral administration of<i>Lactobacillus casei</i>variety<i>rhamnosus</i>partially alleviates TMA-induced atopic dermatitis in mice through improving intestinal microbiota

Yeom, Mijung; Sur, Bongjun; Park, Jihong; Cho, S.G.; Lee, Byeongchan; Kim, S.T.; Kim, K.S.; Lee, H.; Hahm, Dae Hyun

doi:10.1111/jam.12844

Cited by 35 publications

(26 citation statements)

References 39 publications

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“…On the other hand, LOW mice showed a tendency to have a higher abundance of Lactobacillus spp., which was only significant if a general outlier in the LOW group was removed (p = 0.039 with outlier removed), and Lactobacillus spp. may have a possible protective effect against AD, as previous studies have shown that different species of dietary Lactobacillus may relieve AD symptoms in murine models5657585960.…”

Section: Discussionmentioning

confidence: 99%

Sensitivity to oxazolone induced dermatitis is transferable with gut microbiota in mice

Zachariassen

Krych

Engkilde

et al. 2017

Sci Rep

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Atopic Dermatitis (AD) has been associated with gut microbiota (GM) dysbiosis in humans, indicating a causative role of GM in AD etiology. Furthermore, the GM strongly correlates to essential disease parameters in the well-known oxazolone-induced mouse model of AD. Here, we demonstrate that it is possible to transfer both a high-responding and a low-responding AD phenotype with GM from conventional mice to germ-free mice. The mice inoculated with the high-responding GM had significantly higher clinical score, increased ear thickness, and increased levels of IL-1β, TNFα, IL-4, IL-5, and IL-6 compared to the mice inoculated with the low-responding GM. The inter-individual variation was in general not affected by this increase in effect size. Germ-free mice induced with AD revealed a high disease response as well as high inter-individual variation indicating protective properties of certain microbial taxa in this model. This study underlines that the GM has a strong impact on AD in mouse models, and that the power of studies may be increased by the application of mice inoculated with a specific GM from high responders to increase the effect size.

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Section: Discussionmentioning

confidence: 99%

Sensitivity to oxazolone induced dermatitis is transferable with gut microbiota in mice

Zachariassen

Krych

Engkilde

et al. 2017

Sci Rep

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“…Lactobacillus sakei WIKIM30 proved to ameliorate atopic dermatitis skin lesions by T reg -cell induction and altering intestinal microbiota in mice, Lactobacillus casei variety rhamnosus alleviated mice model of induced atopic dermatitis by increasing Bifidobacterium, Lactobacilli, Enterococcus and Bacteroides fragilis levels and decreasing Clostridium coccoides amounts and attenuative effects on skin inflammation in mice was also observed in case of Lactobacillus salivarius LA307 and Lactobacillus rhamnosus LA305. [112][113][114][115] Furthermore, probiotics have shown to present antipruritic effects in AD. 116,117 The meta-analysis carried out by Chang et al 118 supported synbiotics in the AD therapy, especially among 1-year old and older children.…”

Section: Hidradenitis Suppurativamentioning

confidence: 99%

The gut microbiome alterations in allergic and inflammatory skin diseases – an update

Polkowska-Pruszyńska

Gerkowicz

Krasowska

2019

Acad Dermatol Venereol

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The human microbiome is a wide range of microorganisms residing in and on our body. The homeostasis between host immune system and the microbial environment allows mutual benefits and protection. Physiological bacterial colonization is essential for the establishment of organism immunity. The human microbiota ecosystem can be divided into several compartments, out of which intestinal flora strongly affects our health and plays a crucial role in the pathophysiology of many diseases. The gastrointestinal tract, being a major guardian of the immune system, maintains the homeostasis with the commensal microorganisms by tolerating the typical flora antigens. The dysbiosis may trigger an inflammatory response followed by tissue damage or autoimmune processes. The gut microbiome alterations are linked to the pathogenesis of the allergic, cardiovascular, gastrointestinal, metabolic, neurodevelopmental, psychiatric and neurodegenerative diseases and cancer. Moreover, there is increasing evidence connecting the skin condition with the gastrointestinal microbiome, which has been described as the skin–gut axis. The aim of this study was to review the literature regarding the role of the gut microbiome alterations in the pathogenesis of selected allergic and inflammatory skin diseases.

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“…The levels of tyrosine hydroxylase (TH) and tryptophan hydroxylase-1 (Tph1) mRNA expression were measured by RT-PCR according to a method described previously (Yeom et al 2015). In brief, total RNA was isolated from the HPC of each rat using TRIzol reagent according to the manufacturer's instructions.…”

Section: Total Rna Isolation and Reverse Transcriptionpolymerase Chaimentioning

confidence: 99%

The polymethoxylated flavone, Tangeretin improves cognitive memory in rats experiencing a single episode of prolonged post-traumatic stress

Lee

Shim

Lee

et al. 2018

Animal Cells and Systems

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Post-traumatic stress disorder (PTSD) is a stress-related psychiatric/mental condition. Tangeretin (TAN), a major polymethoxylated flavone of citrus plants, exhibits anti-inflammatory and neuroprotective activities. However, whether TAN leads to cognitive improvement in PTSD patients remains unclear. In the present study, we explored whether TAN improved cognitive impairment induced in rats by single prolonged stress (SPS episode mimicking PTSD induction) and determined whether TAN reversed reductions in dopamine (DA) and serotonin (5-HT) levels. Rats were intraperitoneally injected with TAN for 14 consecutive days after the SPS, which had induced cognitive deficits evident in the object recognition task and the Morris water maze test; the impairments were improved by TAN (100 mg/kg). TAN rescued the neurochemical abnormalities and the SPS-induced decreases in DA and 5-HT levels in the hippocampus and amygdala. These effects may be attributable in part to induction of hippocampal genes encoding tyrosine hydroxylase and tryptophan hydroxylase-1. Our results support the idea that rats with PTSD exhibit changes in DAergic and serotonergic transmission and in memory impairment. Thus, TAN mediated reversal of memory-related behavioral dysfunction associated with traumatic stress may be a useful therapeutic intervention in PTSD patients. ARTICLE HISTORY

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Oral administration ofLactobacillus caseivarietyrhamnosuspartially alleviates TMA-induced atopic dermatitis in mice through improving intestinal microbiota

Abstract: LCR35 has a strong potential as a probiotic for preventing AD.

Cited by 35 publications

References 39 publications

Sensitivity to oxazolone induced dermatitis is transferable with gut microbiota in mice

Sensitivity to oxazolone induced dermatitis is transferable with gut microbiota in mice

The gut microbiome alterations in allergic and inflammatory skin diseases – an update

The polymethoxylated flavone, Tangeretin improves cognitive memory in rats experiencing a single episode of prolonged post-traumatic stress

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