Oral administration of tepoxalin in the horse: A PK/PD study

Effects of flunixin meglumine and ketoprofen on mediator production inex vivoandin vitromodels of inflammation in healthy dairy cows

“…Blood samples were collected into plastic tubes containing sodium citrate for the determination of cytokine concentrations. The blood samples to measure TXB 2 concentration were placed into silicon-coated glass tubes, into sodium-heparinized tubes to measure PGE 2 concentration, and into lithium-heparinized tubes to measure LTB 4 concentration (Cuniberti et al, 2012;Giorgi et al, 2011).…”

“…Measurement of LTB 4 concentration. Plasma LTB 4 concentration was measured following the method described by Giorgi et al (2011), but introducing some minor modification. Briefly, aliquots (300 lL) of whole-blood samples added with lithium heparin were incubated at 37°C for 30 min in the presence of calcium ionophore A23187 (Sigma-Aldrich) at concentration of 60 lM to induce the release of LTB 4 by neutrophils.…”

“…Measurement of LTB 4 concentration. Plasma LTB 4 concentration was measured following the method described by Giorgi et al. (2011), but introducing some minor modification.…”

A Brief Overview of the Coxib Drugs in the Veterinary Field

“…However, animal species differences in factors such as the sensitivity and disposition of certain drugs could evoke unexpected results if they are used without any understanding of the drugs' behaviour in the target species (Martignoni et al, 2006;Giorgi et al, 2011;Toutain et al, 1997). In addition, to the best of the Authors' knowledge, the cardiovascular effects of coxibs during protracted therapy have not described in animals.…”

Transmammary-delivered meloxicam in piglets undergoing castration and tail docking: impact on pharmacokinetics and pain biomarkers

“…floor type), environmental, nutritional, and feeding management, over-crowding, gender, genetics, length of tail and lack of substrates [12]. Kritas and Morrison found an increased association between severity of swine tail bite lesions and lung abscesses, pleuritic lesions, and prevalence of external carcass lesions and carcass trimming at the abattoir [13]. Practices used on commercial farms include surgical docking (using side cutters or a sharp knife to remove the tail) or using a cautery iron to sever the tail.…”