Oral anti-inflammatory and anti-ulcerogenic activities of a hydroalcoholic extract and partitioned fractions of Turnera ulmifolia (Turneraceae)

Antônio, Márcia Aparecida; Brito, Alba Regina Monteiro Souza

doi:10.1016/s0378-8741(98)00049-x

Cited by 171 publications

(69 citation statements)

References 32 publications

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“…Based on our findings here, it is plausible to suggest there might be some similar "cytoprotective" agents in T. ramosissimum extracts. Such findings would be consistent with those by SouzaFormigoni et al (1991) and by Antônio and Souza-Brito (1998) who each compared the anti-ulcerogenic activity of lyophilized infusions of, respectively, M. ilicilifolia and M. qualifolium and of Turnera ulmifolia to that of cimetidine, In each case, the precise mechanisms underlying the observed protective effects of those natural products remains unresolved. It has been suggested by others that agents (potentially tannins, polyphenols, and/or flavonoids) impart a measure of gastric mucosa protection through effects on prostaglandin formation (Rainsford, 1989), inhibition of mast cell degranulation (Cho et al, 1976) or proton pumps (Bossolani, 2000), and/or stabilization of lysosomal membranes (Pfeiffer et al, 1987).…”

Section: Discussionsupporting

confidence: 90%

In vitroandin vivoimmunomodulatory and anti-ulcerogenic activities ofTeucrium ramosissimumextracts

Sghaïer¹,

Krifa²,

Mensi³

et al. 2011

Journal of Immunotoxicology

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Section: Discussionsupporting

confidence: 90%

In vitroandin vivoimmunomodulatory and anti-ulcerogenic activities ofTeucrium ramosissimumextracts

Sghaïer¹,

Krifa²,

Mensi³

et al. 2011

Journal of Immunotoxicology

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“…Both the extract and the fractions were observed to inhibit edema induced by carragenine. 5 Turnera subulata Sm., known as "Chanana" or "flor-do-Guarujá," is a herbaceous, shrubby plant with simple leaves; its flowers are white with yellow or orange petals that may or may not be stained at the base. T. subulata Sm.…”

Section: Introductionmentioning

confidence: 99%

CHEMICAL CONSTITUENTS ISOLATED FROMTurnera subulataSm. AND ELECTROCHEMICAL CHARACTERIZATION OF PHAEOPHYTIN B

Filho¹,

Fernandes²,

Chaves³

et al. 2014

Química Nova

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Turnera subulata Sm., known as "Chanana" or "flor-do-Guarujá" in Brazilian folklore, is a plant species belonging to the subfamily Turneroideae of family Passifloraceae, which is used for various medicinal purposes in Brazil. The phytochemical study conducted here led to the isolation and identification of ten compounds present in T. subulata: two mixtures of steroids, sitosterol and stigmasterol (nonglycosylated and glycosylated); a mixture of flavonoids, 5,7,4′-trihidroxiflavona-8-C-α-glucopyranoside and 5,7,3′,4′-tetrahidroxiflavona-8-C-α-glucopyranosidel; and four phaeophytins, phaeophytin purpurin-18-phytyl ester, a rare natural product, phaeophytin a, 13 2 -hydroxy-(13 2 -S)-phaeophytin a, and phaeophytin b. Phaeophytin b exhibited electrochemical activity similar to that of phthalocyanines.

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“…The late phase on the other hand, is mainly mediated by bradykinin, leukotrienes, polymorphonuclear cells and PGs produced in tissue macrophages (Antonio and Souza Brito, 1998;Cuman et al, 2001;Linardi et al, 2002;Vasudevan et al, 2007). The results of the present study suggest that the suppression of inflammation at the early phase was as a result of the antihistamine activity of the plant extract.…”

Section: Discussionmentioning

confidence: 49%

Anti-inflammatory and analgesic activity of the methanol extract of Malva parviflora Linn (Malvaceae) in rats

Afolayan¹,

Aboyade²,

Adedapo³

et al. 2010

Afr. J. Biotechnol.

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Malva parviflora Linn Malvaceae is a medicinal plant used for the treatment of wounds and other related ailments by the Xhosa people of South Africa. The anti-inflammatory activity of the stem extract of this plant was assessed using carrageenan-induced paw oedema and histamine-induced paw oedema. The analgesic effect was determined using the acetic acid writhing method as well as formalin test. The extract at 100 and 200 mgkg -1 body weight reduced significantly, the formation of oedema induced by carrageenan and histamine. In the acetic acid-induced writhing model, the extract showed a good analgesic effect characterized by reduction in the number of writhes when compared to the control. The extract caused dose-dependent decrease of licking time and licking frequency in rats injected with 2.5% formalin, signifying its analgesic effect. These results were also comparable to those of indomethacin, the reference drug used in this study. Since the plant extract reduced significantly the formation of oedema induced by carrageenan and histamine as well as reduced the number of writhes in acetic acidinduced writhing models and dose-dependent decrease of licking time and licking frequency in rats injected with 2.5% formalin, it is concluded that the use of M. parviflora for the treatment of inflammed purulent wounds, swellings, bruises and broken limbs may have been justified.

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Oral anti-inflammatory and anti-ulcerogenic activities of a hydroalcoholic extract and partitioned fractions of Turnera ulmifolia (Turneraceae)

Cited by 171 publications

References 32 publications

In vitroandin vivoimmunomodulatory and anti-ulcerogenic activities ofTeucrium ramosissimumextracts

In vitroandin vivoimmunomodulatory and anti-ulcerogenic activities ofTeucrium ramosissimumextracts

CHEMICAL CONSTITUENTS ISOLATED FROMTurnera subulataSm. AND ELECTROCHEMICAL CHARACTERIZATION OF PHAEOPHYTIN B

Anti-inflammatory and analgesic activity of the methanol extract of Malva parviflora Linn (Malvaceae) in rats

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