Oral antimicrobial peptides and new therapeutic strategies for plaque-mediated diseases

Izadi, Nafiseh; Keikha, Masoud; Ghazvini, Kiarash

doi:10.1016/j.genrep.2020.100811

Cited by 17 publications

(9 citation statements)

References 124 publications

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“…Dental caries is a prevalent oral disease and some acidogenic bacteria like Streptococcus sp. are the main cariesassociated pathogens (Izadi et al, 2020). Several AMPs have good application potential.…”

Section: Current Progress and Application Of Antimicrobial Peptides Mmentioning

confidence: 99%

Antimicrobial Peptides: Classification, Design, Application and Research Progress in Multiple Fields

et al. 2020

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Antimicrobial peptides (AMPs) are a class of small peptides that widely exist in nature and they are an important part of the innate immune system of different organisms. AMPs have a wide range of inhibitory effects against bacteria, fungi, parasites and viruses. The emergence of antibiotic-resistant microorganisms and the increasing of concerns about the use of antibiotics resulted in the development of AMPs, which have a good application prospect in medicine, food, animal husbandry, agriculture and aquaculture. This review introduces the progress of research on AMPs comprehensively and systematically, including their classification, mechanism of action, design methods, environmental factors affecting their activity, application status, prospects in various fields and problems to be solved. The research progress on antivirus peptides, especially anti-coronavirus (COVID-19) peptides, has been introduced given the COVID-19 pandemic worldwide in 2020.

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Section: Current Progress and Application Of Antimicrobial Peptides Mmentioning

confidence: 99%

Antimicrobial Peptides: Classification, Design, Application and Research Progress in Multiple Fields

et al. 2020

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“…Many important prospects for the approved AMPs by the US FDA are used in clinical applications, such as ophthalmology, dental, wound healing, and surgical infection ( Izadi et al, 2020 ). Several AMPs have shown tremendous therapeutic potential against various infectious diseases caused by pathogenic bacteria, including peptide ZXR-2 (FKIGGFIKKLWRSLLA) against pathogenic bacteria of dental caries, Porphyromonas gingivalis , Streptococcus sobrinus , Streptococcus mutans , and peptide PAC-113 (Clinical trial identifier: NCT00659971) as effective antimicrobial agents against oral candidiasis ( Chen et al, 2017 ; Sztukowska et al, 2019 ; Lin et al, 2021 ).…”

Section: Current Progress Of Amps In Medical Applicationsmentioning

confidence: 99%

Targeting Multidrug Resistance With Antimicrobial Peptide-Decorated Nanoparticles and Polymers

Dizaj

Salatin²,

Khezri³

et al. 2022

Front. Microbiol.

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As a category of small peptides frequently found in nature, antimicrobial peptides (AMPs) constitute a major part of the innate immune system of various organisms. Antimicrobial peptides feature various inhibitory effects against fungi, bacteria, viruses, and parasites. Due to the increasing concerns of antibiotic resistance among microorganisms, development of antimicrobial peptides is an emerging tool as a favorable applicability prospect in food, medicine, aquaculture, animal husbandry, and agriculture. This review presents the latest research progress made in the field of antimicrobial peptides, such as their mechanism of action, classification, application status, design techniques, and a review on decoration of nanoparticles and polymers with AMPs that are used in treating multidrug resistance. Lastly, we will highlight recent progress in antiviral peptides to treat emerging viral diseases (e.g., anti-coronavirus peptides) and discuss the outlook of AMP applications.

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“…Dental caries is commonly caused by some acidic bacteria like Straptococcus sp. [207] . AMPs like ZXR-2 and PAC-113 have shown potent activities against microbes such as Streptococcus mutans , Streptococcus sobrinus , and Porphyromonas gingivalis, and Candida sp.…”

Section: Application Of Amps Against Mdr Pathogensmentioning

confidence: 99%

Multidrug resistance crisis during COVID-19 pandemic: Role of anti-microbial peptides as next-generation therapeutics

Sharma

Barman

Joshi

et al. 2022

Colloids and Surfaces B: Biointerfaces

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The decreasing effectiveness of conventional drugs due to multidrug-resistance is a major challenge for the scientific community, necessitating development of novel antimicrobial agents. In the present era of coronavirus 2 (COVID-19) pandemic, patients are being widely exposed to antimicrobial drugs and hence the problem of multidrug-resistance shall be aggravated in the days to come. Consequently, revisiting the phenomena of multidrug resistance leading to formulation of effective antimicrobial agents is the need of the hour. As a result, this review sheds light on the looming crisis of multidrug resistance in wake of the COVID-19 pandemic. It highlights the problem, significance and approaches for tackling microbial resistance with special emphasis on anti-microbial peptides as next-generation therapeutics against multidrug resistance associated diseases. Antimicrobial peptides exhibit exceptional mechanism of action enabling rapid killing of microbes at low concentration, antibiofilm activity, immunomodulatory properties along with a low tendency for resistance development providing them an edge over conventional antibiotics. The review is unique as it discusses the mode of action, pharmacodynamic properties and application of antimicrobial peptides in areas ranging from therapeutics to agriculture.

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Oral antimicrobial peptides and new therapeutic strategies for plaque-mediated diseases

Cited by 17 publications

References 124 publications

Antimicrobial Peptides: Classification, Design, Application and Research Progress in Multiple Fields

Antimicrobial Peptides: Classification, Design, Application and Research Progress in Multiple Fields

Targeting Multidrug Resistance With Antimicrobial Peptide-Decorated Nanoparticles and Polymers

Multidrug resistance crisis during COVID-19 pandemic: Role of anti-microbial peptides as next-generation therapeutics

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