Oral Corticosteroids did not Prevent AGEP due to Terbinafine

Acute generalized exanthematous pustulosis after pemetrexed, and recurrence after re-introduction

“…Use of intravenous corticosteroids during the second infusion of pemetrexed could not prevent recurrence of AGEP in our patient. This phenomenon was previously described in a previous case of AGEP caused by terbinafine 8 . However, the fact that a low dose of dexamethasone did not prevent the recurrence of AGEP is not an indication that steroids would not be effective at higher dosages.…”

“…This phenomenon was previously described in a previous case of AGEP caused by terbinafine. 8 However, the fact that a low dose of dexamethasone did not prevent the recurrence of AGEP is not an indication that steroids would not be effective at higher dosages.…”

Risk factors for acute generalized exanthematous pustulosis (AGEP)—results of a multinational case–control study (EuroSCAR)

“…Terbinafine 3, [28][29][30][31][32][33][34][35][36][37] In our study all four cases associated with antimycotic drugs had taken terbinafine. Onset of the reaction was 26, 13, 11 and 9 days after beginning of intake of the drug.…”

Acute generalized exanthematous pustulosis: atypical presentations and outcomes

“…Specifically, sulfa medications have been reported to produce AGEP in oval erythematous and edematous plaques with pinpoint pustules . In addition, AGEP has been described with other atypical medication triggers including anti‐hypertensives (atenolol, nifedipine and diltiazem), antimycotics (terbinafineand itraconazole) antibiotics (minocycline, sulfapyridine and clindamycin), paracetamol, allopurinol, anti‐inflammatory medications (corticosteroids and oxicam NSAIDs, hydroxychloroquine, dexamethasone), icodextran (a peritoneal dialysate), and intravenous radiocontrast media . We highlight these medications to alert the clinician to the possibility of AGEP with atypical medication triggers.…”